Results 1 to 10 of about 286,536 (215)

Impaired immune surveillance of senescent hepatocytes in MASLD: SASP signaling and fibrogenic progression [PDF]

Frontiers in Immunology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is sustained not only by lipid overload and hepatocellular injury but also by maladaptive responses to persistent metabolic stress.
Shuhao Cheng, Yinan Zhao, Wei Wang
doaj   +2 more sources

B cell-mediated immune surveillance defines the favorable prognosis of occult breast cancer: a multi-omics study [PDF]

Frontiers in Immunology
BackgroundOccult breast cancer (OBC) presents with axillary lymph node (ALN) metastases without detectable primary tumor (PT) yet exhibits paradoxically favorable prognosis compared to non-occult breast cancer (non-OBC).
Junjie Liu, Rui Zhang, Ziyan Li, Xiaoqian Li, Xuetao Yuan, Jingyi Zhang, Na Chai, Yunpeng Zhang, Huimin Zhang   +8 more
doaj   +2 more sources

Safety and Immunogenicity of Inactivated Whole Virion COVID-19 Vaccine CoviVac in Clinical Trials in 18–60 and 60+ Age Cohorts

Viruses, 2023
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, safety, and immunogenicity of the inactivated whole virion concentrated purified coronavirus vaccine CoviVac in ...
Ilya V. Gordeychuk, Liubov I. Kozlovskaya, Aleksandra A. Siniugina, Nadezhda V. Yagovkina, Vladimir I. Kuzubov, Konstantin A. Zakharov, Viktor P. Volok, Maria S. Dodina, Larissa V. Gmyl, Natalya A. Korotina, Rostislav D. Theodorovich, Yulia I. Ulitina, Dmitry I. Vovk, Marina V. Alikova, Anna A. Kataeva, Anna V. Kalenskaya, Irina V. Solovjeva, Elena V. Tivanova, Larissa Y. Kondrasheva, Antonina A. Ploskireva, Vasiliy G. Akimkin, Ksenia A. Subbotina, Georgy M. Ignatyev, Anastasia K. Korduban, Elena Y. Shustova, Ekaterina O. Bayurova, Alla S. Zhitkevich, Daria V. Avdoshina, Anastasia N. Piniaeva, Anastasia A. Kovpak, Liliya P. Antonova, Yulia V. Rogova, Anna A. Shishova, Yury Y. Ivin, Svetlana E. Sotskova, Konstantin A. Chernov, Elena G. Ipatova, Ekaterina A. Korduban, Aydar A. Ishmukhametov   +38 more
doaj   +1 more source

MicroRNAs Regulating Tumor and Immune Cell Interactions in the Prediction of Relapse in Early Stage Breast Cancer

Biomedicines, 2021
MicroRNAs (miRNAs) are involved in the regulation of immune response and hold an important role in tumor immune escape. We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of ...
Chara Papadaki, Konstantina Thomopoulou, Alexia Monastirioti, George Koronakis, Maria A. Papadaki, Konstantinos Rounis, Lambros Vamvakas, Christoforos Nikolaou, Dimitrios Mavroudis, Sofia Agelaki   +9 more
doaj   +1 more source

Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer

Frontiers in Cell and Developmental Biology, 2021
Thyroid cancer is the most prevalent endocrine malignancy in the United States with greater than 53,000 new cases in 2020. There is a significant gender disparity in disease incidence as well, with women developing thyroid cancer three times more often ...
Timmy J. O’Connell, Sina Dadafarin, Melanie Jones, Tomás Rodríguez, Tomás Rodríguez, Anvita Gupta, Edward Shin, Augustine Moscatello, Codrin Iacob, Humayun Islam, Raj K. Tiwari, Jan Geliebter, Jan Geliebter   +12 more
doaj   +1 more source

Tumor immune microenvironment in therapy‐naive esophageal adenocarcinoma could predict the nodal status

Cancer Medicine, 2023
Background Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and intratumoral
Andromachi Kotsafti, Matteo Fassan, Francesco Cavallin, Valentina Angerilli, Luca Saadeh, Matteo Cagol, Rita Alfieri, Pierluigi Pilati, Carlo Castoro, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa   +11 more
doaj   +1 more source

Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling

Frontiers in Immunology, 2022
Cancer immunotherapy uses the immune system to achieve therapeutic effects; however, its effect is still limited. Therefore, in addition to immune checkpoint-based treatment, the development of other strategies that can inhibit cancer cells from ...
Jei-Ming Peng, Ching-Feng Chiu, Jai-Hong Cheng, Jai-Hong Cheng, Hui-Ying Liu, Yin-Lun Chang, Jia-Wun Luo, Yu-Ting Weng, Hao-Lun Luo   +8 more
doaj   +1 more source

Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response

OncoImmunology, 2020
After neoadjuvant chemoradiotherapy for esophageal adenocarcinoma, up to 29% of patients have a pathological complete response (pCR). What to do afterward is still under debate.
Andromachi Kotsafti, Melania Scarpa, Francesco Cavallin, Matteo Fassan, Roberta Salmaso, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo, Marco Scarpa   +12 more
doaj   +1 more source

Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10

Frontiers in Immunology, 2020
Tumor immune escape is an important part of tumorigenesis and development. Tumor cells can develop a variety of immunosuppressive mechanisms to combat tumor immunity.
Shan-Shan Yin, Feng-Hou Gao
doaj   +1 more source

Patients With Microscopic Colitis Have Altered Levels of Inhibitory and Stimulatory Biomarkers in Colon Biopsies and Sera Compared to Non-inflamed Controls

Frontiers in Medicine, 2021
Introduction: Microscopic colitis (MC) is an inflammatory bowel condition with two subtypes, lymphocytic colitis (LC) and collagenous colitis (CC). Unlike patients with ulcerative colitis (UC) and non-inflamed individuals, MC patients have reduced risk ...
Alexandra Lushnikova, Johan Bohr, Anna Wickbom, Andreas Münch, Klas Sjöberg, Olof Hultgren, Anders Wirén, Elisabeth Hultgren Hörnquist   +7 more
doaj   +1 more source