Results 21 to 30 of about 286,536 (215)

A Tumor Profile in Primary Immune Deficiencies Challenges the Cancer Immune Surveillance Concept

Frontiers in Immunology, 2018
Under the concept of cancer immune surveillance, individuals with primary immune deficiencies would be expected to develop many more malignancies and show an excess of all types of cancers, compared to people with a normal immune system.
Daniel Satgé
doaj   +1 more source

Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma

Nature Communications
PD-1/PD-L1 blockade has so far shown limited survival benefit for high-grade ovarian carcinomas. By using paired samples from the NeoPembrOv randomized phase II trial (NCT03275506), for which primary outcomes are published, and by combining RNA-seq and ...
Olivia Le Saux, Maude Ardin, Justine Berthet, Sarah Barrin, Morgane Bourhis, Justine Cinier, Yasmine Lounici, Isabelle Treilleux, Pierre-Alexandre Just, Guillaume Bataillon, Aude-Marie Savoye, Marie-Ange Mouret-Reynier, Elodie Coquan, Olfa Derbel, Louis Jeay, Suliman Bouizaguen, Intidhar Labidi-Galy, Séverine Tabone-Eglinger, Anthony Ferrari, Emilie Thomas, Christine Ménétrier-Caux, Eric Tartour, Isabelle Galy-Fauroux, Marc-Henri Stern, Magali Terme, Christophe Caux, Bertrand Dubois, Isabelle Ray-Coquard   +27 more
doaj   +1 more source

Lymph Node Immune Profiles as Predictive Biomarkers for Immune Checkpoint Inhibitor Response

Frontiers in Molecular Biosciences, 2021
The need for predictive biomarkers that can accurately predict patients who will respond to immune checkpoint inhibitor (ICI) immunotherapies remains a clinically unmet need.
Emily F. Goode, Emily F. Goode, Evanthia T. Roussos Torres, Sheeba Irshad, Sheeba Irshad   +4 more
doaj   +1 more source

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer

Frontiers in Immunology, 2018
Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence.
Alessandro Mangogna, Beatrice Belmonte, Chiara Agostinis, Giuseppe Ricci, Giuseppe Ricci, Alessandro Gulino, Ines Ferrara, Fabrizio Zanconati, Claudio Tripodo, Federico Romano, Uday Kishore, Roberta Bulla   +11 more
doaj   +1 more source

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment

Frontiers in Immunology, 2021
The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber, Christoph M. Hammers, Achim J. Kaasch, Achim J. Kaasch, Burkhart Schraven, Burkhart Schraven, Anne Dudeck, Anne Dudeck, Sascha Kahlfuss, Sascha Kahlfuss, Sascha Kahlfuss   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mechanistic Association of Hepatoblastoma with Cerebral Palsy: A Narrative Review

Saudi Journal of Medicine and Medical Sciences
Hepatoblastoma is a rare liver cancer that occurs most often in children who present with lower birth weight. Cerebral palsy (CP) is a neurodevelopmental disorder distinguished by irregularities in muscle tone, movement, and motor skills. CP is caused by
Noor Saeed Hasan, Warren Thomas
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Rapid Immune Modulation after Consuming Euglena gracilis Whole Algae Involving Altered Responses to Ex Vivo Immune Challenges: A Placebo-Controlled Cross-Over Trial

Nutraceuticals
Euglena gracilis (EG) microalgae has immune-modulating properties, partly due to its unique intracellular β-glucan-granules (paramylon). We evaluated the effects of EG consumption on immune status in vivo, ex vivo, and in vitro.
Ifeanyi Iloba, Dina Cruickshank, Krista Sanchez, Solli Brawer, Omer Grundman, Gitte S. Jensen   +5 more
doaj   +1 more source