Results 11 to 20 of about 286,536 (215)

Preliminary analysis of double‐negative T, double‐positive T, and natural killer T‐like cells in B‐cell chronic lymphocytic leukemia

Cancer Medicine, 2023
Background B‐cell chronic lymphocytic leukemia (B‐CLL) is characterized by the expansion of CD5+ malignant B lymphocytes. Recent discoveries have shown that double‐negative T (DNT) cells, double‐positive T (DPT) cells, and natural killer T (NKT)‐cells ...
Luciana Valvano, Filomena Nozza, Giovanni D'Arena, Fiorella D'Auria, Luciana De Luca, Giuseppe Pietrantuono, Giovanna Mansueto, Oreste Villani, Simona D'Agostino, Daniela Lamorte, Giovanni Calice, Teodora Statuto   +11 more
doaj   +1 more source

Immunoediting and Antigen Loss: Overcoming the Achilles Heel of Immunotherapy with Antigen Non-Specific Therapies

Frontiers in Oncology, 2013
Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy.
Arta Monir Monjazeb, Anthony E Zamora, Steven K Grossenbacher, Annie eMirsoian, Gail D Sckisel, William J Murphy   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance. [PDF]

Mol Oncol
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Tiwary K, Bravo-Cordero JJ.
europepmc   +2 more sources

Immune surveillance as a pharmacological target in the early stages of cancer [PDF]

Frontiers in Molecular Biosciences
Hongfei Jiang, Hongfei Jiang, Zhun Wei, Zhun Wei, Haibo Zhao, Haibo Zhao   +5 more
doaj   +2 more sources

Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS

Frontiers in Immunology, 2019
While the brain is considered an immune-privileged site, the CNS may nevertheless be the focus of immune mediated inflammation in the case of infection and certain autoimmune diseases, e.g., multiple sclerosis. As in other tissues, it has been found that
Amalie S. Schøller, Masja Fonnes, Loulieta Nazerai, Jan P. Christensen, Allan R. Thomsen   +4 more
doaj   +1 more source

A Recombinant Fragment of Human Surfactant Protein D induces Apoptosis in Pancreatic Cancer Cell Lines via Fas-Mediated Pathway

Frontiers in Immunology, 2018
Human surfactant protein D (SP-D) is a potent innate immune molecule, which is emerging as a key molecule in the recognition and clearance of altered and non-self targets.
Anuvinder Kaur, Muhammad Suleman Riaz, Valarmathy Murugaiah, Praveen Mathews Varghese, Shiv K. Singh, Uday Kishore   +5 more
doaj   +1 more source

Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies

Cells, 2023
Life expectancy has drastically increased over the last few decades worldwide, with important social and medical burdens and costs. To stay healthy longer and to avoid chronic disease have become essential issues.
Roula Khalil, Mona Diab-Assaf, Jean-Marc Lemaitre   +2 more
doaj   +1 more source

Using Murine Models to Investigate Tumor–Lymphoid Interactions: Spotlight on Chronic Lymphocytic Leukemia and Angioimmunoblastic T-Cell Lymphoma

Frontiers in Oncology, 2017
The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive.
Christine E. Cutucache, Tyler A. Herek
doaj   +1 more source

Matrilysin [MMP-7] Expression Selects for Cells with Reduced Sensitivity to Apoptosis

Neoplasia: An International Journal for Oncology Research, 2001
The matrix metalloproteinase matrilysin (MMP-7) has been demonstrated to contribute to tumor development. We have shown previously that members of the TNF family of apoptosis-inducing proteins are substrates for this enzyme, resulting in increased death ...
Barbara Fingleton, Tracy Vargo-Gogola, Howard C. Crawford, Lynn M. Matrisian   +3 more
doaj   +1 more source

Genetically Engineered Mouse Models Support a Major Role of Immune Checkpoint-Dependent Immunosurveillance Escape in B-Cell Lymphomas

Frontiers in Immunology, 2021
These last 20 years, research on immune tumor microenvironment led to identify some critical recurrent mechanisms used in cancer to escape immune response. Through immune checkpoints, which are cell surface molecules involved in the immune system control,
Quentin Lemasson, Quentin Lemasson, Hussein Akil, Hussein Akil, Jean Feuillard, Jean Feuillard, Christelle Vincent-Fabert, Christelle Vincent-Fabert   +7 more
doaj   +1 more source