Results 21 to 30 of about 71,028 (295)

برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس ‌اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی, آمنه رئوف رحمتی, سید علیرضا اسماعیلی   +2 more
doaj   +1 more source

CD80 expression on microglia.

, 2022
Mean fluorescence intensity of CD80 on microglia isolated from the brains of WT and Mavs-/- mice, +/- RVFV infection. (TIF)
Feliza A. Bourguet (12563078), Aimy Sebastian (823355), Doris Lam (529392), Gabriela G. Loots (12563087), Amy Rasley (18287), Nicholas R. Hum (12563075), Kristina R. Sanchez (12563084), Ashlee M. Phillips (12563081), Dina R. Weilhammer (11102115)   +8 more
core   +1 more source

Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish

Frontiers in Immunology, 2022
The moderate activation of T cells in mammals requires the costimulatory molecules, CD80 and CD86, on antigen-presenting cells to interact with their respective T cell receptors, CD28 and CD152 (CTLA-4), to promote costimulatory signals.
Tao-Zhen Lu, Xun Liu, Chang-Song Wu, Zi-You Ma, Yang Wang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +12 more
doaj   +1 more source

Calreticulin arms NK cells against leukemia

OncoImmunology, 2020
Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure
Jitka Fucikova, Justin P. Kline, Lorenzo Galluzzi, Radek Spisek   +3 more
doaj   +1 more source

Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease [PDF]

, 2015
[b][/b][b]Introduction. [/b]The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral
Izabela Roszko-Kirpsza, Landowski, P., Barbara Kamińska, Szlagatys-Sidorkiewicz, A., Guzinska-Ustymowicz, K., Piotr Landowski, Kaminska, B., Roszko-Kirpsza, I., Agnieszka Szlagatys- Sidorkiewicz, Katarzyna Guzińska-Ustymowicz, Maciorkowska, E., Elżbieta Maciorkowska   +11 more
core   +2 more sources

Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer

Human Vaccines & Immunotherapeutics, 2020
Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor clinical outcome is attributed to a lack of defined targets and patient-to-patient heterogeneity in ...
Christopher D. Pack, Ramireddy Bommireddy, Luis E. Munoz, Jaina M. Patel, Erica N. Bozeman, Paulami Dey, Vijayaraghavan Radhakrishnan, Vincent F. Vartabedian, Kalpana Venkat, Sampath Ramachandiran, Shaker J. C. Reddy, Periasamy Selvaraj   +11 more
doaj   +1 more source

Extending the B7 (CD80) gene family [PDF]

Protein Science, 1994
AbstractB7‐1 and B7‐2 are members of the immunoglobulin superfamily (IgSF) and important regulators of T cell‐mediated immune responses. Despite sharing only limited sequence identity, B7‐1 and B7‐2 bind common receptors, CD28 and CTLA‐4, on T cells and have similar functional properties.
P S, Linsley, R, Peach, P, Gladstone, J, Bajorath   +3 more
openaire   +2 more sources

Maximal ‘CD80-uria’ with minimal change [PDF]

Kidney International, 2010
Differentiation between minimal-change disease and focal segmental glomerulosclerosis remains challenging, particularly at early stages in children and adults. Garin et al. identify urinary CD80 excretion levels as a potential marker to differentiate the former entity from the latter. Thus, CD80 expression on podocytes, which was initially described in
Kistler, Andreas D., Reiser, Jochen
openaire   +2 more sources

CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis [PDF]

, 2015
In patients with ulcerative colitis (UC) the cumulative risk of colon cancer is lower than the actual rate of dysplasia suggesting an efficient immune surveillance mechanism.
Carlo Castoro1, PORZIONATO, ANDREA, Marco Scarpa1, Susan Morgan3, §, *, Andromachi Kotsafti1, Andrea Buda4, MACCHI, VERONICA, CASTAGLIUOLO, IGNAZIO, BORTOLAMI, MARINA, ANGRIMAN, IMERIO, BRUN, PAOLA, Renata D’Incà4, RUGGE, MASSIMO, Melania Scarpa1, STURNIOLO, GIACOMO, BARDINI, ROMEO   +17 more
core   +1 more source

Triggering of lymphocytes by CD28, 4-1BB, and PD-1 checkpoints to enhance the immune response capacities

PLoS ONE, 2022
Tumor infiltrating lymphocytes (TILs) usually become exhausted and dysfunctional owing to chronic contact with tumor cells and overexpression of multiple inhibitor receptors.
Elina Kaviani, Ahmad Hosseini, Elham Mahmoudi Maymand, Mani Ramzi, Abbas Ghaderi, Amin Ramezani   +5 more
doaj   +2 more sources