Results 21 to 30 of about 65,297 (255)

Level of HSV-1 immediate early, early, and CD80 in HSV-CD80 infected DCs. [PDF]

, 2014
Subconfluent monolayers of DCs from C57BL/6 mice were infected with 1 PFU/cell of HSV-CD80 or parental virus as in Fig. 1. For ICP-0 and TK measurements, cells were isolated 4, 8, and 12 hr PI, while for CD80 measurements cells were harvested 2, 4, 8, 12,
Omid Akbari (390206), Homayon Ghiasi (229574), Mandana Zandian (229553), Pedram Hamrah (445781), Steven L. Wechsler (514676), Arlene H. Sharpe (154508), Sariah J. Allen (229565), Kevin R. Mott (229559), Hadi Maazi (285077), Gordon J. Freeman (267166)   +9 more
core   +1 more source

Calreticulin arms NK cells against leukemia

OncoImmunology, 2020
Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure
Jitka Fucikova, Justin P. Kline, Lorenzo Galluzzi, Radek Spisek   +3 more
doaj   +1 more source

CD80/86 inhibitors : abatacept [PDF]

, 2016
CD80/CD86 inhibitors are protein constructs which bind and inactivate CD80/CD86 on the surfaces of antigen-presenting B-cells and monocytes, blocking the costimulatory signal between these cells and CD28 on T-cells that is the second message of T-cell ...
Mahler, Stephen M., Pile, Kevin (R17082), Stephen M. Mahler, Garry G. Graham, Kevin D. Pile, Graham, Garry G.   +5 more
core   +1 more source

DataSheet1_Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer.docx [PDF]

, 2022
Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Shengze Zhang (12904991), Jianqiang Shao (12904988), Qin Zhang (58638), Chaowei Gao (12904985), Zunyi Wang (12904994), Peng Wang (34436)   +5 more
core   +1 more source

Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish

Frontiers in Immunology, 2022
The moderate activation of T cells in mammals requires the costimulatory molecules, CD80 and CD86, on antigen-presenting cells to interact with their respective T cell receptors, CD28 and CD152 (CTLA-4), to promote costimulatory signals.
Tao-Zhen Lu, Xun Liu, Chang-Song Wu, Zi-You Ma, Yang Wang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +12 more
doaj   +1 more source

Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer

Human Vaccines & Immunotherapeutics, 2020
Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor clinical outcome is attributed to a lack of defined targets and patient-to-patient heterogeneity in ...
Christopher D. Pack, Ramireddy Bommireddy, Luis E. Munoz, Jaina M. Patel, Erica N. Bozeman, Paulami Dey, Vijayaraghavan Radhakrishnan, Vincent F. Vartabedian, Kalpana Venkat, Sampath Ramachandiran, Shaker J. C. Reddy, Periasamy Selvaraj   +11 more
doaj   +1 more source

Signaling through CD80: an approach for treating lymphomas [PDF]

, 2008
Background: One of the mechanisms by which tumors evade the immune system is by downregulating the expression of costimulatory molecules like CD80 and CD86.
Mir, Manzoor A., Agrewala, Javed N., Manzoor A Mir, Javed N Agrewala   +3 more
core   +1 more source

Image1_Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer.tif [PDF]

, 2022
Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Shengze Zhang (12904991), Jianqiang Shao (12904988), Qin Zhang (58638), Chaowei Gao (12904985), Zunyi Wang (12904994), Peng Wang (34436)   +5 more
core   +1 more source

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers [PDF]

, 2017
Purpose: A shear stress-induced atherosclerosismouse model was characterized for its expression of inflammation markers with focus on CD80. With this model, we evaluated two positron emission tomography (PET) radiotracers targeting CD80 as well as 2 ...
Chiotellis, Aristeidis, Ametamey, Simon M, Meletta, Romana, Russo, Erica, Mu, Linjing, Borel, Nicole, Halin, Cornelia, Steier, Larissa, Mu, Linjing; id_orcid, Krämer, Stefanie-Dorothea; id_orcid, Keller, Claudia, Müller Herde, Adrienne, Krämer, Stefanie D, Schibli, Roger, Ametamey, Simon M.   +14 more
core   +1 more source

CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis [PDF]

, 2015
In patients with ulcerative colitis (UC) the cumulative risk of colon cancer is lower than the actual rate of dysplasia suggesting an efficient immune surveillance mechanism.
Carlo Castoro1, PORZIONATO, ANDREA, Marco Scarpa1, Susan Morgan3, §, *, Andromachi Kotsafti1, Andrea Buda4, MACCHI, VERONICA, CASTAGLIUOLO, IGNAZIO, BORTOLAMI, MARINA, ANGRIMAN, IMERIO, BRUN, PAOLA, Renata D’Incà4, RUGGE, MASSIMO, Melania Scarpa1, STURNIOLO, GIACOMO, BARDINI, ROMEO   +17 more
core   +1 more source