Frontiers in Immunology, 2022 The CD80/86 molecule is one of the important co-stimulatory ligands and involves antigen-specific immune responses by ligating with CD28 and then delivering the required second signal to T-cell activation. In this study, a CD80/86 homolog was identified,
Wenjing Liu +8 more
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Epigenetics, 2020 CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos +9 more
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Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer
Frontiers in Pharmacology, 2022 Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Qin Zhang +5 more
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Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients [PDF]
Türk Patoloji DergisiObjective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are ...
Esra COBANKENT AYTEKIN +3 more
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Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. [PDF]
PLoS ONE, 2014 CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latency ...
Kevin R Mott +9 more
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Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease [PDF]
, 2015 [b][/b][b]Introduction. [/b]The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral
Izabela Roszko-Kirpsza +11 more
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برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی +2 more
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DAC educated CD80 positive, but not CD80 negative EL4 cells induce T cell responses. [PDF]
, 2013 (A) EL4 cells were treated with DAC. CD80+ and CD80− EL4 cells were separated by flow cytometry-based sorting. Flow cytometric analysis of CD80 expression in EL4 cells before and after sorting is shown.
Yi Ding (172783) +19 more
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CD80 blockade preferentially improves survival after CLP. [PDF]
, 2013 Panel A-WT C57BL/6 mice were administered either 250 µg anti-CD80, anti -CD86 or both 4 hrs prior to CLP and monitored for survival (n = 10/group). Data from anti -CD80/86 has been published previously [18]. P = 0.002 for anti-CD80 vs. control.
Hiroshi Kobayashi (23858) +9 more
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Expression of CD80 by HSV-CD80 in infected DCs. [PDF]
, 2014 A) Detection of HSV-1 gC in infected DCs. Subconfluent monolayers of DCs isolated from C57BL/6 mice were infected with 1 PFU/cell of HSV-CD80, parental virus, or mock infected.
Omid Akbari (390206) +9 more
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