Results 11 to 20 of about 69,003 (290)

CD80 (B7-1) as a potential therapeutic target in Epstein–Barr virus‑associated B cell diseases [PDF]

Scientific Reports
Epstein-Barr virus (EBV)-associated B-cell lymphomas pose a therapeutic challenge due to their resistance to conventional chemotherapy and limited efficacy of current targeted approaches.
Rin Yoshizato, Mariko Miura, Yumi Tamura, Yohei Kawano, Yuya Hokama, Nanami Soda, Yusei Ota, Kotomi Yamashita, Taisei Fukushima, Masataka Ishimura, Shouichi Ohga, Tomoharu Yasuda   +11 more
doaj   +2 more sources

CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles

Human Immunology, 2012
CD80 and CD86 are closely linked genes on chromosome 3 that code for glycoproteins of the immunoglobulin superfamily, expressed on the surface of antigen-presenting cells. These costimulatory molecules play essential roles for stimulation and inhibition of T cells through binding to CD28 and CTLA-4 receptors.
Márcia Holsbach, Beltrame, Márcia Regina, Pincerati, Ricardo, Dalla-Costa, Roseli, Wassem, Karen Francine, Köhler, Eleidi Alice, Chautard-Freire-Maia, Luiza Tamie, Tsuneto, Maria Luiza, Petzl-Erler   +7 more
openaire   +3 more sources

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms [PDF]

Kidney International, 2005
CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms.BackgroundCD80 and CD86 costimulatory molecules have been shown to affect the induction of Th1-mediated crescentic antiglomerular basement membrane (GBM)
A Richard Kitching, Stephen R Holdsworth, Peter G Tipping   +2 more
exaly   +2 more sources

Signaling through CD80: an approach for treating lymphomas

Expert Opinion on Therapeutic Targets, 2008
One of the mechanisms by which tumors evade the immune system is by downregulating the expression of costimulatory molecules like CD80 and CD86. The role of CD80 in the activation of T cells is well established, and current studies are exploring its role in cancer.To examine the possible role of CD80 signaling in generating an effective immune response
Manzoor A, Mir, Javed N, Agrewala
openaire   +3 more sources

Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes

Pediatric Nephrology, 2013
Background: Minimal change disease (MCD) is the most common cause of nephrotic syndrome in children and is associated with the expression of CD80 in podocytes and the increased excretion of CD80 in urine. We hypothesized that serum from patients with MCD
Clive Wasserfall, Eduardo Garin, Gabriel Cara-Fuentes   +2 more
exaly   +2 more sources

Expression of CD80 and HLA-DR molecules on blood monocytes in patients with pulmonary tuberculosis

Медицинская иммунология, 2021
We examined expression pattern of CD80 and HLA-DR pro-inflammatory molecules on the monocytes in patients with pulmonary tuberculosis (TB), depending on the clinical form of the disease and susceptibility of the pathogen to anti-tuberculosis drugs.
E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, S. P. Chumakova, Yu. V. Kolobovnikova, E. O. Kazakova   +6 more
doaj   +1 more source

Elevated urinary CD80 excretion in children with steroid-responsive nephrotic syndrome

Biomedical and Biotechnology Research Journal, 2022
Background: Idiopathic nephrotic syndrome (INS) is one of the most common glomerular diseases in children with different pathological types and different responses to corticosteroids.
Nakysa Hooman, Hasan Otukesh, Rozita Hosseini, Azar Nickavar, Farzaneh Dastan, Mahboubeh Jafari Sarouei, Parisa Honarpisheh   +6 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection. [PDF]

Adv Sci (Weinh)
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Meurisse F, Coindre S, Wijkhuisen A, Marlin R, Fournier Le Ray L, Pons J, Yaugel-Novoa M, Avettand-Fenoel V, Abi-Rached L, Gallouet AS, Relouzat F, Gourves M, Saez-Cirion A, Arase H, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Le Grand R, Simon S, Lambotte O, Favier B.   +20 more
europepmc   +2 more sources

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source