Results 11 to 20 of about 71,028 (295)

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction

Cell Reports
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prevents
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom   +11 more
doaj   +4 more sources

Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors [PDF]

JTO Clinical and Research Reports, 2023
Introduction: Unresectable or recurrent thymic epithelial tumors (TETs) have a poor prognosis, and treatment options are limited. This study aimed to investigate the immunologic significance of CD80/CD86 or major histocompatibility complex class II (MHC ...
Hideki Ikeda, MD, Joji Nagasaki, MD, PhD, Daiki Shimizu, MD, Yuki Katsuya, MD, PhD, Hidehito Horinouchi, MD, PhD, Yukio Hosomi, MD, PhD, Etsuko Tanji, MS, Takekazu Iwata, MD, PhD, Makiko Itami, MD, PhD, Masahito Kawazu, MD, PhD, Yuichiro Ohe, MD, PhD, Takuji Suzuki, MD, PhD, Yosuke Togashi, MD, PhD   +12 more
doaj   +3 more sources

Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.

PLoS ONE, 2009
BackgroundInflammation in the early stages of sepsis is governed by the innate immune response. Costimulatory molecules are a receptor/ligand class of molecules capable of regulation of inflammation in innate immunity via macrophage/neutrophil contact ...
Anna Nolan, Hiroshi Kobayashi, Bushra Naveed, Ann Kelly, Yoshihiko Hoshino, Satomi Hoshino, Matthew R Karulf, William N Rom, Michael D Weiden, Jeffrey A Gold   +9 more
doaj   +2 more sources

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers [PDF]

Molecular Imaging and Biology, 2017
Purpose: A shear stress-induced atherosclerosismouse model was characterized for its expression of inflammation markers with focus on CD80. With this model, we evaluated two positron emission tomography (PET) radiotracers targeting CD80 as well as 2 ...
Chiotellis, Aristeidis, Ametamey, Simon M, Meletta, Romana, Russo, Erica, Mu, Linjing, Borel, Nicole, Halin, Cornelia, Steier, Larissa, Mu, Linjing; id_orcid, Krämer, Stefanie-Dorothea; id_orcid, Keller, Claudia, Müller Herde, Adrienne, Krämer, Stefanie D, Schibli, Roger, Ametamey, Simon M., Borel N, Russo E, Mu L, Schibli R, Halin C, Chiotellis A, Steier L, Ametamey SM, Keller C, Müller Herde A, Krämer SD, Meletta R   +26 more
core   +7 more sources

Presence of CD80 and Absence of LAT in Modulating Cellular Infiltration and HSV-1 Latency

Viruses
CD80 is the best-known costimulatory molecule for effective T cell functions. Many different reports have summarized the role of CD80 in HSV-1 and its functions in maintaining adaptive immunity, which is the main player in causing herpes stromal ...
Ujjaldeep Jaggi, Homayon Ghiasi
doaj   +2 more sources

CD80 costimulation is essential for the induction of airway eosinophilia [PDF]

The Journal of Experimental Medicine, 1997
CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation.
Linsley, P. S., Peach, R., Le Gros, G., Ronchese, F., Naemura, J., Harris, N.   +5 more
core   +5 more sources

Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection [PDF]

The Journal of Immunology, 2000
The CD28 costimulatory pathway is critical to T cell activation. Blockade of the interaction of CD28 with its ligands CD80 and CD86 using CTLA4-Ig has been proposed as a therapy for a number of immune-based disorders.
Harris, N. L., Roberts, J. M., Peach, R. J., Lumsden, J. M., Ronchese, F.   +4 more
core   +6 more sources

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma [PDF]

BMC Cancer, 2007
Background B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of ...
Lin Hsuan-Yu, Hsu Nicholas C, Chang Julia H, Chang Cheng-Shyong, Chung Chih-Yuan   +4 more
doaj   +3 more sources

Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer

Frontiers in Pharmacology, 2022
Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Qin Zhang, Chaowei Gao, Jianqiang Shao, Shengze Zhang, Peng Wang, Zunyi Wang   +5 more
doaj   +1 more source

Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients [PDF]

Türk Patoloji Dergisi
Objective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are ...
Esra COBANKENT AYTEKIN, Betul UNAL, Cumhur Ibrahim BASSORGUN, Ozlenen OZKAN   +3 more
doaj   +1 more source