Results 21 to 30 of about 107,086 (298)
Iraqi Journal of Hematology, 2023 BACKGROUND: Multiple myeloma is a clonal B-cell malignancy characterized by proliferation of plasma cells that secrete a complete and/or partial monoclonal immunoglobulin protein.
Zahraa Mahdi Sareeh +2 more
doaj +1 more source
, 2023 BackgroundChimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients.
Georg Hopfinger (14347098) +22 more
core +1 more source
CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]
, 2013 CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon +46 more
core +2 more sources
Frontiers in Immunology, 2022 ObjectivesThis study aimed to elucidate the changes and associated mechanisms of circulating CD28- cytotoxic T lymphocytes (CTLs) in patients with IgG4-related disease (IgG4-RD).MethodsFifty IgG4-RD patients and 15 healthy controls (HCs) were recruited ...
Chang-sheng Xia +5 more
doaj +1 more source
Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses. [PDF]
PLoS Pathogens, 2014 IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing an importance
Hlumani Ndlovu +6 more
doaj +1 more source
Increased Neopterin Concentration in Older Age Coincides with Decline of CD28+CD45RA+ T-cells
Pteridines, 2004 Neopterin is produced from human monocyte-derived macrophages and dendritic cells upon Stimulation with interferon-y, and increased neopterin concentrations thus indicate cell-mediated immune activation.
Murr Christian +7 more
doaj +1 more source
Journal of Inflammation Research, 2021 Li Dong,1 Yu-Min Zheng,2 Xiao-Guang Luo,3 Zhi-Yi He2 1Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of China ...
Dong L, Zheng YM, Luo XG, He ZY
doaj
BELATACEPT IN RENAL TRANSPLANTATION
Вестник трансплантологии и искусственных органов, 2013 Belatacept is a novel immunosuppressive agent that inhibits T-cell activation by blocking CD28 signaling pa- thway. It was developed based on abatacept (CTLA-4Ig), the first recombinant immunoglobulin fusion protein which contains extracellular part of ...
A. I. Sushkov, Y. G. Moysyuk
doaj +1 more source
Epigenetics, 2020 CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos +9 more
doaj +1 more source
Serum antibodies against CD28-- a new potential marker of dismal prognosis in melanoma patients. [PDF]
PLoS ONE, 2013 BACKGROUND: Autoantibodies against CD28 have been found in patients with autoimmune and atopic diseases. These antibodies may act as superagonists and activate T cells but may also be antagonistic or induce immunosuppressive effects by activating ...
Rebecca Körner +12 more
doaj +1 more source