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Tumor-Associated Macrophages in Tumor Immunity [PDF]
Frontiers in Immunology, 2020 Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Yueyun Pan +5 more
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The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy [PDF]
Journal of Experimental & Clinical Cancer ResearchImmunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunotherapy response, accumulating evidence ...
Raheleh Roudi +4 more
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Tumor-Associated Macrophages: Recent Insights and Therapies
Frontiers in Oncology, 2020 Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells.
Jiawei Zhou +7 more
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Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment [PDF]
Advanced Pharmaceutical Bulletin, 2020 Tumor microenvironment consists of malignant and non-malignant cells. The interaction of these dynamic and different cells is responsible for tumor progression at different levels.
Somaiyeh Malekghasemi +5 more
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Morphological heterogeneity of intratumoral macrophages in prostate tumors
Сибирский онкологический журнал, 2023 Background. Prostate cancer (PCa) is the most common human cancer worldwide. In the progression of prostate cancer, the total number of macrophages in the tumor tissue is associated with poor prognosis and increased risk of metastasis.
K. V. Danilko +6 more
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Tumor-Associated Macrophages: A Potential Target for Cancer Therapy
Frontiers in Oncology, 2021 Macrophages, an important class of innate immune cells that maintain body homeostasis and ward off foreign pathogens, exhibit a high degree of plasticity and play a supportive role in different tissues and organs.
Yifan Tan +6 more
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Frontiers in Immunology, 2023 Recent studies have revealed that tumor-associated macrophages are the most abundant stromal cells in the tumor microenvironment and play an important role in tumor initiation and progression.
Mengyuan Li +4 more
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Tumor-Associated Macrophages: Critical Players in Drug Resistance of Breast Cancer
Frontiers in Immunology, 2021 Drug resistance is one of the most critical challenges in breast cancer (BC) treatment. The occurrence and development of drug resistance are closely related to the tumor immune microenvironment (TIME).
Maoyu Xiao +5 more
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Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy
Frontiers in Oncology, 2020 Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant ...
Zhong-Wei Luo +12 more
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Tumor-Associated Neutrophils and Macrophages—Heterogenous but Not Chaotic
Frontiers in Immunology, 2020 Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, and sometimes appeared to be inconsistent across ...
Ling Wu +6 more
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