Results 31 to 40 of about 9,505,641 (261)

Progress of research on the relationship between efferocytosis and tumor

Frontiers in Oncology
Tumors are genetic changes that develop in an organism as a result of many internal and external causes. They affect the biological behavior of cells, cause them to grow independently, and give rise to new, perpetually proliferating organisms.
Xuexin Yao, Ling Zhang, Siyi Sun, Aishuang Fu, Yanlei Ge   +4 more
doaj   +1 more source

Research Progress of M2-type Tumor-associated Macrophages in Lung Cancer

Zhongliu Fangzhi Yanjiu, 2022
Tumor-associated macrophages (TAMs) account for a large proportion in tumor stroma, and can be divided into M1 type (anti-tumoral) and M2 type (pro-tumoral).
WAN Xiaoying, ZHOU Songwen
doaj   +1 more source

FABP4 deactivates NF‐κB‐IL1α pathway by ubiquitinating ATPB in tumor‐associated macrophages and promotes neuroblastoma progression

Clinical and Translational Medicine, 2021
Neuroblastoma (NB) is the most common and deadliest pediatric solid tumor. Targeting and reactivating tumor‐associated macrophages (TAMs) is necessary for reversing immune suppressive state and stimulating immune defense to exert tumoricidal function ...
Lei Miao, Zhenjian Zhuo, Jue Tang, Xiaomei Huang, Jiabin Liu, Hai‐Yun Wang, Huimin Xia, Jing He   +7 more
doaj   +1 more source

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Biomarker Research, 2021
Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences suggest that potential mechanisms of macrophage-mediated tumor immune escape imply ...
Yingqi Qiu, Tong Chen, Rong Hu, Ruiyi Zhu, Chujun Li, Yingchen Ruan, Xiaoling Xie, Yuhua Li   +7 more
doaj   +1 more source

Tissue-Resident and Recruited Macrophages in Primary Tumor and Metastatic Microenvironments: Potential Targets in Cancer Therapy

Cells, 2021
Macrophages within solid tumors and metastatic sites are heterogenous populations with different developmental origins and substantially contribute to tumor progression.
Tiziana Cotechini, Aline Atallah, Arielle Grossman   +2 more
doaj   +1 more source

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Experimental Hematology & Oncology, 2021
Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity
Shangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu   +4 more
doaj   +1 more source

Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase [PDF]

, 2010
Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions. Here we used mice deficient of heparanase (Hpse−/−) to study the impact of heparanase on airway leukocytes.
Vlodavsky, Israel, Li, Jin-ping, Zcharia, Eyal, Pejler, Gunnar, Jia, Juan, Li, Jin-Ping,, Waern, Ida, Jia, Juan,, Wernersson, Sara, Sveriges lantbruksuniversitet., Waern, Ida,, Pejler, Gunnar,, Wernersson, Sara,   +12 more
core   +1 more source

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Signal Transduction and Targeted Therapy, 2021
The current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these advanced diseases, but their therapeutic responses are suboptimal and vary considerably among ...
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu   +3 more
doaj   +1 more source

Exosomal MicroRNAs Mediating Crosstalk Between Cancer Cells With Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in the Tumor Microenvironment

Frontiers in Oncology, 2021
Exosomes are small extracellular vesicles containing diverse bioactive molecules. They play essential roles in mediating bidirectional interplay between cancer and stromal cells. Specific elements are selected into different types of exosomes via various
Tong Su, Panpan Zhang, Fujun Zhao, Shu Zhang   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source