Results 1 to 10 of about 1,149,461 (264)

Monitoring Radiographic Brain Tumor Progression

Toxins, 2011
Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and ...
John H. Sampson, Darell D. Bigner, Allan H. Friedman, Charles W. Kanaly, Ankit I. Mehta   +4 more
doaj   +3 more sources

A Mammary Organoid Model to Study Branching Morphogenesis

Frontiers in Physiology, 2022
Branching morphogenesis is the process that gives rise to branched structures in several organs, such as the lung, the kidney, and the mammary gland. Although morphologically well described, the exact mechanisms driving branch elongation and bifurcation ...
Marika Caruso, Sjanie Huang, Larissa Mourao, Larissa Mourao, Colinda L. G. J. Scheele, Colinda L. G. J. Scheele   +5 more
doaj   +1 more source

Detection of Glycosylated Markers From Cancer Stem Cells With ColoSTEM Dx Kit for Earlier Prediction of Colon Cancer Aggressiveness

Frontiers in Oncology, 2022
Nowadays, colon cancer prognosis still difficult to predict, especially in the early stages. Recurrences remain elevated, even in the early stages after curative surgery.
Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Serge Battu, Alain Chauvanel, Alain Chauvanel, Vincent Carré, Marie-Odile Jauberteau, Marie-Odile Jauberteau, Fabrice Lalloué, Muriel Mathonnet, Muriel Mathonnet   +16 more
doaj   +1 more source

A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies

Cells, 2022
Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells.
Céline Hervieu, Mireille Verdier, Elodie Barthout, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet   +8 more
doaj   +1 more source

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

Frontiers in Immunology, 2021
Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer, Hannah Wurzer, Liza Filali, Céline Hoffmann, Max Krecke, Max Krecke, Andrea Michela Biolato, Andrea Michela Biolato, Jérôme Mastio, Sigrid De Wilde, Jean Hugues François, Anne Largeot, Guy Berchem, Guy Berchem, Jérôme Paggetti, Etienne Moussay, Clément Thomas   +16 more
doaj   +1 more source

Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse

Frontiers in Immunology, 2020
Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system.
Jérôme Mastio, Mezida B. Saeed, Hannah Wurzer, Max Krecke, Lisa S. Westerberg, Clément Thomas   +5 more
doaj   +1 more source

The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

Scientific Reports, 2022
Evidence from previous studies suggests a protective effect of metformin in patients with colorectal cancer (CRC). The aim of this study was to examine the associations between metformin use and overall survival (OS) and disease-free survival (DFS) in ...
Zeinab Tarhini, Kamelia Manceur, Julien Magne, Muriel Mathonnet, Jeremy Jost, Niki Christou   +5 more
doaj   +1 more source

Clinical management of molecular alterations identified by high throughput sequencing in patients with advanced solid tumors in treatment failure: Real-world data from a French hospital

Frontiers in Oncology, 2023
BackgroundIn the context of personalized medicine, screening patients to identify targetable molecular alterations is essential for therapeutic decisions such as inclusion in clinical trials, early access to therapies, or compassionate treatment.
Sandra Pinet, Stéphanie Durand, Alexandre Perani, Léa Darnaud, Fifame Amadjikpe, Mathieu Yon, Tiffany Darbas, Alain Vergnenegre, Thomas Egenod, Yannick Simonneau, Valérie Le Brun-Ly, Julia Pestre, Laurence Venat, Frédéric Thuillier, Alain Chaunavel, Alain Chaunavel, Mathilde Duchesne, Mathilde Duchesne, Véronique Fermeaux, Anne Guyot, Sylvain Lacorre, Barbara Bessette, Fabrice Lalloué, Karine Durand, Karine Durand, Elise Deluche, Elise Deluche   +26 more
doaj   +1 more source

Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells

Neoplasia: An International Journal for Oncology Research, 2008
Analyzing the growth of fibrosarcoma lines derived from IL-1α–, IL-1β–, or IL-1αβ–knockout (−/−) mice in the immunocompetent host revealed that tumor-derived IL-1α and IL-1β exert strong and opposing effects on immune response induction, which prohibited
Irina Nazarenko, Rachid Marhaba, Eli Reich, Elena Voronov, Mario Vitacolonna, Dagmar Hildebrand, Elena Elter, Mohini Rajasagi, Ron N. Apte, Margot Zöller   +9 more
doaj   +1 more source

Prognostic models for early and late tumor progression prediction in nasopharyngeal carcinoma: An analysis of 8292 endemic cases

Cancer Medicine, 2023
Objectives The time for posttreatment tumor progression differs between nasopharyngeal carcinoma (NPC) patients. Herein, we established effective nomograms for predicting early tumor progression (ETP) and late tumor progression (LTP) in NPC patients ...
Lu‐Lu Zhang, Wei‐hong Zheng, Wei‐jie Zhu, Qi‐Ling Deng, Jun‐Ling Peng, Yi‐Yang Li, Ying Sun, Li Lin   +7 more
doaj   +1 more source