Results 41 to 50 of about 1,149,461 (264)
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Inflammation in tumor progression
Folia Pharmacologica Japonica, 2011 転移とは病名であり臨床的知見は大きな価値をもつ．画像診断は転移の空間的情報をもたらすと同時に，その質的な所見は原発巣だけでなく転移巣における組織病理学的知見を支持する．がんの進行は血液・血清学的な変化をもたらし，臨床的に治療の有効性や経過の判断に重要である．この変化する分子や細胞の動態こそが，原発巣が遠隔操作の媒体として遠隔臓器にがん細胞を移動させる手段と考えられる．臨床像に類似性の高い実験動物を利用した転移モデルは存在しないため，樹立された複数の人工的転移系で得られた証拠をもとに多くの転移論が主張されている．われわれの視点もその1つであり，転移臓器における本来の生理的機能の恒常性維持に関与している分子プログラムが原発巣によって質的・量的変化を受けた結果であると考えている．具体的には，肺転移の場合 ...
openaire +3 more sources
OverAKT3: tumor progression and chemoresistance [PDF]
Cell Cycle, 2015 Akt3 is one of 3 closely related serine/threonine-protein kinases in the Akt family (Akt1, Akt2, and Akt3). Akt is among the most hyperactivated oncogenes in human cancer, regulating key cellular functions such as growth, proliferation, migration, invasion, angiogenesis, metabolism, and survival.1,2 Studies evaluating the effect of Akt isoform gene ...
Ping, Ji, Kristen M, Turner, Wei, Zhang
openaire +2 more sources
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source
Restore the brake on tumor progression [PDF]
Biochemical Pharmacology, 2017 Sonic hedgehog (Shh) signaling plays a key role in regulation of normal development. The negative feedback mechanism mediated by the transcriptional factor, Gli3, acts to finely tune Shh signaling, providing tight control of normal developmental processes.
Renata E, Gordon +2 more
openaire +2 more sources
Fluids and Barriers of the CNSGlioblastoma (GBM) is the most aggressive and common primary brain tumor in adults and remains associated with a dismal prognosis despite standard-of-care treatment.
Mohamed Abd Naceur Ammar +5 more
doaj +1 more source
Emerging Treatments Targeting the Tumor Microenvironment for Advanced Chondrosarcoma
CellsChondrosarcoma (ChS), a malignant cartilage-producing tumor, is the second most frequently diagnosed osseous sarcoma after osteosarcoma. It represents a very heterogeneous group of malignant chemo- and radiation-resistant neoplasms, accounting for ...
Vincenzo Ingangi +10 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body‐altering treatment. This cross‐sectional study aimed to evaluate generic and survivor‐specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and ...
Hinke van der Hoek +14 more
wiley +1 more source
Open Veterinary JournalBackground: Natural plant-derived compounds are increasingly explored as safer alternatives to chemotherapy due to their multi-targeted anticancer properties.
Juma Al-Mutaani +4 more
doaj +1 more source