Results 61 to 70 of about 3,117,179 (310)

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Understanding hairy cell leukemia in the context of mature B−cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis

Frontiers in Immunology
Mature B-cell neoplasms constitute a biologically and clinically heterogeneous group of hematologic malignancies, defined by the clonal proliferation and accumulation of monotypic mature B lymphocytes, which may involve the peripheral blood, bone marrow (
Vincenzo Ingangi, Dominga Amoroso, Eugenia Passaro, Vincenzo Di Vaia, Filippo Maltoni, Ghazal Narimanfar, Michele Minopoli, Rita Rosa, Mariateresa Ametrano, Elena Di Gennaro, Alessandro Broccoli, Alessandro Broccoli, Pier Luigi Zinzani, Pier Luigi Zinzani, Lucia Catani, Lucia Catani, Chiara Ciardiello   +16 more
doaj   +1 more source

Suppressioin of tumor progression of murine regressor tumor cells by transfection with manganese superoxide dismutase gene [PDF]

, 1998
P(論文)近年,癌治療技術の進歩に伴い口腔癌の治療成績も向上してきているが,未だ癌細胞の有する造腫瘍性,浸潤・転移能などの悪性形質に起因する再発,転移により制御不能となる場合も少なくないのが現状である。癌細胞の悪性形質は,必ずしも発癌当初より備わっているわけではなく,主に発癌後の増殖過程において周囲の微小環境との関わり,特に炎症局所において高頻度,長時間持続放出される活性酸素の影響などによって,遺伝子変化が蓄積し獲得されているらしいことが種々の臓器の癌で証明されて来ている。また ...
中井, 一元, 25316
core  

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Molecular Cancer, 2019
Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression.
Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren, Jianhua Wang   +6 more
doaj   +1 more source

CXCL8 in Tumor Biology and Its Implications for Clinical Translation

Frontiers in Molecular Biosciences, 2022
The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong, Xinyang Liao, Shi Qiu, Shi Qiu, Hang Xu, Shiyu Zhang, Sheng Wang, Jianzhong Ai, Lu Yang   +8 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Modeling blood–brain barrier–glioblastoma interactions: implications for chemoresistance and therapeutic targeting

Fluids and Barriers of the CNS
Glioblastoma (GBM) is the most aggressive and common primary brain tumor in adults and remains associated with a dismal prognosis despite standard-of-care treatment.
Mohamed Abd Naceur Ammar, Simona Dobiasova, Iris Chiara Salaroglio, Sihem Hmissa, Nabiha Missaoui, Chiara Riganti   +5 more
doaj   +1 more source

Emerging Treatments Targeting the Tumor Microenvironment for Advanced Chondrosarcoma

Cells
Chondrosarcoma (ChS), a malignant cartilage-producing tumor, is the second most frequently diagnosed osseous sarcoma after osteosarcoma. It represents a very heterogeneous group of malignant chemo- and radiation-resistant neoplasms, accounting for ...
Vincenzo Ingangi, Annarosaria De Chiara, Gerardo Ferrara, Michele Gallo, Antonio Catapano, Flavio Fazioli, Gioconda Di Carluccio, Elisa Peranzoni, Ilaria Marigo, Maria Vincenza Carriero, Michele Minopoli   +10 more
doaj   +1 more source

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth [PDF]

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
core   +2 more sources