Results 31 to 40 of about 1,149,461 (264)

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

mLST8 Promotes mTOR-Mediated Tumor Progression. [PDF]

PLoS ONE, 2015
The activity of the mechanistic target of rapamycin (mTOR) is elevated in various types of human cancers, implicating a role in tumor progression. However, the molecular mechanisms underlying mTOR upregulation remain unclear. In this study, we found that
Kyoko Kakumoto, Jun-Ichiro Ikeda, Masato Okada, Eiichi Morii, Chitose Oneyama   +4 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

The Role of MSCs in the Tumor Microenvironment and Tumor Progression [PDF]

Anticancer Research, 2020
Over the past few decades, longevity without disease has become an important topic worldwide. However, as life expectancy increases, the number of patients with cancer is also increasing. Tumor progression is related to interactions between tumor cells and mesenchymal stem cells (MSCs) in the tumor microenvironment.
openaire   +3 more sources

Investigation of Epstein–Barr virus or human cytomegalovirus in pediatric gliomas: A retrospective single-center study from Tunisia

Biochemistry and Biophysics Reports
The involvement of infectious agents in glioma pathogenesis remains controversial. While adult gliomas have been extensively studied, the potential contribution of viral infections to pediatric gliomagenesis is poorly understood.
Nabiha Missaoui, Ahlem Bdioui, Zaineb Lajmi, Syrine Moussa, Yosra Suiden, Nouha Jradi, Oussama Belkacem, Amal Bouazzi, Sarra Mestiri, Ksira Iadh, Sihem Hmissa   +10 more
doaj   +1 more source

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Molecular Cancer, 2019
Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression.
Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren, Jianhua Wang   +6 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Understanding hairy cell leukemia in the context of mature B−cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis

Frontiers in Immunology
Mature B-cell neoplasms constitute a biologically and clinically heterogeneous group of hematologic malignancies, defined by the clonal proliferation and accumulation of monotypic mature B lymphocytes, which may involve the peripheral blood, bone marrow (
Vincenzo Ingangi, Dominga Amoroso, Eugenia Passaro, Vincenzo Di Vaia, Filippo Maltoni, Ghazal Narimanfar, Michele Minopoli, Rita Rosa, Mariateresa Ametrano, Elena Di Gennaro, Alessandro Broccoli, Alessandro Broccoli, Pier Luigi Zinzani, Pier Luigi Zinzani, Lucia Catani, Lucia Catani, Chiara Ciardiello   +16 more
doaj   +1 more source

CXCL8 in Tumor Biology and Its Implications for Clinical Translation

Frontiers in Molecular Biosciences, 2022
The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong, Xinyang Liao, Shi Qiu, Shi Qiu, Hang Xu, Shiyu Zhang, Sheng Wang, Jianzhong Ai, Lu Yang   +8 more
doaj   +1 more source