Results 21 to 30 of about 1,149,461 (264)

The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?

Biomedicines, 2020
Metastasis is known as the most life-threatening event in cancer patients. In principle, the immune system can prevent tumor development. However, dysfunctional T cells may fail to eliminate the tumor cells effectively and provide additional survival ...
Chin-King Looi, Ling-Wei Hii, Siew Ching Ngai, Chee-Onn Leong, Chun-Wai Mai   +4 more
doaj   +1 more source

Tumor Progression, Microenvironments, and Therapeutics

Life, 2022
Tumor malignancy starts from transformation [...]
Hung-Chi Cheng, Li-Tzu Huang
doaj   +1 more source

Vasculogenic Mimicry: A Potential Therapeutic Target for Chondrosarcoma Therapy

Cells
Chondrosarcomas (ChSs) are mesenchymal chemo- and radiation-resistant tumors, representing the second most frequently diagnosed bone sarcoma after osteosarcoma and 20% of all bone sarcomas.
Vincenzo Ingangi, Roberta Gatti, Gioconda Di Carluccio, Vincenzo Di Vaia, Margherita Cerrone, Gerardo Ferrara, Sara Scala, Maurizio Maddalena, Michele Gallo, Flavio Fazioli, Chiara Ciardiello, Michele Minopoli, Maria Vincenza Carriero   +12 more
doaj   +1 more source

Progress in the cryoablation and cryoimmunotherapy for tumor

Frontiers in Immunology, 2023
With the rapid advancement of imaging equipment and minimally invasive technology, cryoablation technology is being used more frequently in minimally invasive treatment of tumors, primarily for patients with early tumors who voluntarily consent to ablation as well as those with advanced tumors that cannot be surgically removed or cannot be tolerated ...
Zenan Chen, Liangliang Meng, Liangliang Meng, Jing Zhang, Xiao Zhang   +4 more
openaire   +3 more sources

Microsatellite instability and mismatch repair deficiency in bladder urothelial carcinoma: a Tunisian single-center study

Journal of the Egyptian National Cancer Institute
Background Microsatellite instability (MSI) and deficiency in the human mismatch repair (MMR) system are critical drivers of genomic instability in various cancers.
Ahlem Bdioui, Mariem Akkari, Maroua Krifa, Yosra Souiden, Ethmane Sleimane, Wafa Mokni, Nada Ben Lazrek, Sarra Mestiri, Sihem Hmissa, Nabiha Missaoui   +9 more
doaj   +1 more source

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

Journal of Hematology & Oncology, 2019
Background Cell-cell interactions maintain tissue homeostasis and contribute to dynamic alteration of the tumor microenvironment (TME). Communication between cancer and host cells not only promotes advanced disease aggression but also determines ...
Wei-Lun Hwang, Hsin-Yi Lan, Wei-Chung Cheng, Shih-Ching Huang, Muh-Hwa Yang   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

Frontiers in Oncology, 2020
The tumor microenvironment (TME) is composed of various cell types embedded in an altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also regulates cell–cell or cell–matrix cross-talks.
Sylvie Brassart-Pasco, Sylvie Brassart-Pasco, Stéphane Brézillon, Stéphane Brézillon, Bertrand Brassart, Bertrand Brassart, Laurent Ramont, Laurent Ramont, Laurent Ramont, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean Claude Monboisse, Jean Claude Monboisse, Jean Claude Monboisse   +14 more
doaj   +1 more source

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Experimental Hematology & Oncology, 2021
Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity
Shangli Zhu, Ming Yi, Yuze Wu, Bing Dong, Kongming Wu   +4 more
doaj   +1 more source