Results 51 to 60 of about 9,505,641 (261)

DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages

, 2020
Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers and is an independent marker of poor prognosis.
Lisa M. Privette Vinnedge, Mathieu Sertorio, Nicholas A. Pease, Miranda S. Shephard, Susan E. Waltz   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Therapeutic Targeting of Tumor-Associated Macrophages in Pancreatic Neuroendocrine Tumors. [PDF]

, 2018
Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neuroendocrine neoplasms with varying biological behaviour and response to treatment. Although targeted therapies have been shown to improve the survival for patients at advanced
Sebastian Krug, Wiese, Dominik, Hüttelmaier, Stefan, Krug, Sebastian, Stefan Hüttelmaier, Johannes Haybaeck, Abbassi, Rami, Bence Sipos, Gress, Thomas M, Rami Abbassi, Haybaeck, Johannes, Aurel Perren, Perren, Aurel, Michl, Patrick, Sipos, Bence, Anja Rinke, Dominik Wiese, Thomas M. Gress, Peter Rexin, Rexin, Peter, Patrick Michl, Griesmann, Heidi, Heidi Griesmann, Blank, Annika, Rinke, Anja, Annika Blank   +25 more
core   +2 more sources

Tumor-Associated Macrophages Promote Metastasis of Oral Squamous Cell Carcinoma via CCL13 Regulated by Stress Granule

, 2022
M2 tumor-associated macrophages (TAMs) have been a well-established promoter of oral squamous cell carcinoma (OSCC) progression. However, the mechanisms of M2 TAMs promoting OSCC metastasis have not been elucidated clearly.
Shule Xie, Zhou, Bin, Min Fu, Xie, Shule, Zhu, Chuandong, Youyuan Wang, Guotao Wu, Zhixin Liu, Rui, Tao, Lianxi Mai, Liu, Zhixin, Mai, Lianxi, Bin Zhou, Tao Rui, Zhaoyu Lin, Wu, Guotao, Chuandong Zhu, Fu, Min, Lin, Zhaoyu, Wang, Youyuan   +19 more
core   +1 more source

Distinct Role of CD11b⁺Ly6G⁻Ly6C⁻ Myeloid-Derived Cells on the Progression of the Primary Tumor and Therapy-Associated Recurrent Brain Tumor

Cells, 2019
Myeloid-derived cells have been implicated as playing essential roles in cancer therapy, particularly in cancer immunotherapy. Most studies have focused on either CD11b+Ly6G+Ly6C+ granulocytic or polymorphonuclear myeloid-derived suppressor cells (G ...
Sheng-Yan Wu, Chi-Shiun Chiang
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment

Marine Drugs, 2014
The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective activation/up-regulation or loss of function serve to impart aberrant properties, such as hyperproliferation or ...
Carlos M. Galmarini, Maurizio D'Incalci, Paola Allavena   +2 more
doaj   +1 more source

Tumor-Associated Macrophages: Recent Insights and Therapies

Frontiers in Oncology, 2020
Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells.
Jiawei Zhou, Jiawei Zhou, Ziwei Tang, Ziwei Tang, Siyang Gao, Chunyu Li, Yiting Feng, Xikun Zhou   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source