Results 271 to 280 of about 57,461 (287)
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Nanobodies against porcine CD163 as PRRSV broad inhibitor
International Journal of Biological Macromolecules, 2023PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) is a major swine pathogen causing economic losses. To the date, effective broad PRRSV inhibitory strategies have not been available in practice yet. Targeting the key viral receptor CD163 to block PRRSV entry has emerged as an alternative approach beside vaccines for PRRSV inhibition.
Zhuofan, Deng +8 more
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Biological variation of soluble CD163
Scandinavian Journal of Clinical and Laboratory Investigation, 2003A soluble plasma form of CD163 (sCD163) was recently identified. The protein has anti-inflammatory effects in vitro and is elevated in patients with myelo-monocytic leukaemia and infection. For rational use and evaluation of this potential new quantity it is important to have knowledge of its biological variability and to use a methodology that has a ...
Møller, Holger Jon +3 more
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Scandinavian Journal of Clinical and Laboratory Investigation, 2011
CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes. As a result of ectodomain shedding, the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) at 0.7-3.9 mg/l in healthy individuals.
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CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes. As a result of ectodomain shedding, the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) at 0.7-3.9 mg/l in healthy individuals.
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The clinical utility of CD163 in viral diseases
Clinica Chimica Acta, 2023Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype.
Yap, Yi-Jing +7 more
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Soluble CD163 Inhibits Phorbol Ester-Induced Lymphocyte Proliferation
Biochemical and Biophysical Research Communications, 2001CD163 is a member of the scavenger receptor cysteine-rich family which is expressed exclusively on human monocytes and macrophages. Upon an inflammatory stimulus the protein is shed rapidly from the membranes' surface. CD163 expression is significantly upregulated by glucocorticoids and IL-10.
P, Högger, C, Sorg
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The significance of CD163-expressing macrophages in asthma
Annals of Allergy, Asthma & Immunology, 2019CD163 is one of the scavenger receptors that are specifically expressed on macrophages and are well known to be upregulated by various inflammatory responses, including chronic obstructive pulmonary disease in airway diseases.To evaluate the CD163 expression in the lungs of patients with fatal asthma and investigated whether CD163 contributes to the ...
Yoshihisa, Tokunaga +4 more
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Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis
The American Journal of the Medical Sciences, 2015CD163, a marker of M2 macrophages, possesses anti-inflammatory properties. This study aims to investigate the clinicopathological significance of CD163-positive macrophages in proliferative glomerulonephritis.Renal tissue samples from patients with lupus nephritis (LN, n = 22), antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune ...
Jun, Li +3 more
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Journal of Gastroenterology, 2005
The levels of several cytokines and chemokines are elevated in various liver diseases, especially in fulminant hepatic failure (FHF). Activated macrophages may have a role in the production of these immune modulators. CD163 is a member of a scavenger receptor family and is expressed mainly on activated macrophages, and a soluble form of CD163 (sCD163 ...
Atsushi, Hiraoka +5 more
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The levels of several cytokines and chemokines are elevated in various liver diseases, especially in fulminant hepatic failure (FHF). Activated macrophages may have a role in the production of these immune modulators. CD163 is a member of a scavenger receptor family and is expressed mainly on activated macrophages, and a soluble form of CD163 (sCD163 ...
Atsushi, Hiraoka +5 more
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CD163 and its expanding functional repertoire.
Clinica chimica acta; international journal of clinical chemistry, 2012Macrophages are key players of the immune system and express a variety of surface receptors. CD163 is one such receptor which belongs to the scavenger receptor cysteine-rich super family (SRCR-SF) class B. It has four isoforms which differ in the structure of their cytoplasmic domains and putative phosphorylation sites.
P, Akila +4 more
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The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human and murine CD163 protein and to applications of such polypeptides such as for use as diagnostic agent, for example as an immunotracer. The invention further relates to conjugates, in particular conjugates of polypeptides comprising an
Van Ginderachter, Jo +5 more
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Van Ginderachter, Jo +5 more
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