Results 21 to 30 of about 113,104 (262)

Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia

OncoImmunology, 2018
CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential.
Christian Kellner, Matthias Peipp, Martin Gramatzki, Martin Schrappe, Denis M. Schewe   +4 more
doaj   +1 more source

Association Between Serum Ferritin and CD19/CD34 Expression in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Bioscience and Applied Research
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, characterized by malignant proliferation and accumulation of lymphoblasts in the bone marrow.
Karrar Tikki, Haider Jaffat
doaj   +1 more source

Getting CD19 Into Shape: Expression of Natively Folded “Difficult-to- Express” CD19 for Staining and Stimulation of CAR-T Cells

Frontiers in Bioengineering and Biotechnology, 2020
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion
Elisabeth Lobner, Anna Wachernig, Venugopal Gudipati, Patrick Mayrhofer, Benjamin Salzer, Manfred Lehner, Johannes B. Huppa, Renate Kunert   +7 more
doaj   +1 more source

CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients

Turkish Journal of Hematology, 2018
Seven years ago a chronic lymphocytic leukemia patient was for the first time successfully treated with chimeric antigen receptor (CAR)-modified T cells (CAR-T cells) to target CD19 overexpression in tumor cells. This was the beginning of the development
Lorena Perez - Amill, Berta Marzal, Alvaro Urbano - Ispizua, Manel Juan, Beatriz Martín - Antonio   +4 more
doaj   +1 more source

Association of CD24, CD27, and co-stimulatory molecules CD80 immunological marker expression on B-cells of human peripheral blood with development of celiac disease

Iraqi Journal of Hematology
BACKGROUND: B-cells express a variety of clusters of differentiation markers during development. These markers determine the basic function of the immune phenotype specific to B-cells.
Rahab Abd-Ali Al-Madany, Noor Abdulameer Oudah   +1 more
doaj   +1 more source

CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma

OncoImmunology, 2022
B cell lymphoma therapy has been transformed by CD19-targeting cellular therapeutics that induce high clinical response rates and impressive remissions in relapsed and refractory patients.
Lihe Su, Lan Wu, Roy R. Lobb, Paul D. Rennert, Christine Ambrose   +4 more
doaj   +1 more source

Assessment of selected B cells populations in the workers of X-ray departments

International Journal of Occupational Medicine and Environmental Health, 2014
Objectives: Workers of X-ray departments are occupationally exposed to long-term low levels of ionizing radiation (LLIR), which may affect their humoral immunity.
Piotr Kłuciński, Bogdan Mazur, Łukasz Sędek, Małgorzata Aptekorz, Paweł Cieślik, Antoni Hrycek, Gayane Martirosian   +6 more
doaj   +1 more source

Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases

BMC Nephrology, 2021
Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function.
Jieshan Lin, Bin Tang, Zhanwu Feng, Wenke Hao, Wenxue Hu   +4 more
doaj   +1 more source

Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation

Frontiers in Immunology, 2021
The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets of BMPC suggest potential different functions.
Annika Wiedemann, Annika Wiedemann, Marie Lettau, Marie Lettau, Ina Wirries, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E. Mei, Carsten Perka, Jörn Walter, Andreas Radbruch, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner   +16 more
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CD19 EKSİKLİĞİ TANISINDA RFLP YÖNTEMİNİN KULLANIMI

Genel Tıp Dergisi, 2021
B lenfosit yüzeyinde bulunan CD19 molekülü olgun B hücrelerinde CD21, CD81, CD225 ile birlikte CD19 kompleksini oluşturur ve antijen uyarısı ile birlikte B lenfosit aktivasyonunu düzenler. CD19 molekülünü kodlayan gende oluşacak mutasyonlar, CD19 protein
İsmail Reisli, Mehmet Karaselek, Hatice Efe, Hasan Kapaklı, Yahya Gül, Sevgi Keleş, Şükrü Güner, Ercan Kurar   +7 more
doaj   +1 more source