Results 41 to 50 of about 126,758 (293)

Image_3_Probiotic Lactobacillus rhamnosus GG Induces Alterations in Ileal Microbiota With Associated CD3-CD19-T-bet+IFNγ+/- Cell Subset Homeostasis in Pigs Challenged With Salmonella enterica Serovar 4,[5],12:i:-.TIF

, 2019
Salmonella enterica serovar 4,[5],12:i:- (S. 4,[5],12:i:-) is an emerging foodborne pathogen causing salmonellosis in humans and animals. Probiotic Lactobacillus rhamnosus GG (LGG) is an effective strategy for controlling enteric infections through ...
Guiyan Yang (4786875), Jiufeng Wang (1600588), Haifeng Ji (780358), Wei Zhang (405), Jiao Yu (4097278), Yaohong Zhu (6671660), Qiong Wu (84327)   +6 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Table_1_Probiotic Lactobacillus rhamnosus GG Induces Alterations in Ileal Microbiota With Associated CD3-CD19-T-bet+IFNγ+/- Cell Subset Homeostasis in Pigs Challenged With Salmonella enterica Serovar 4,[5],12:i:-.DOC

, 2019
Salmonella enterica serovar 4,[5],12:i:- (S. 4,[5],12:i:-) is an emerging foodborne pathogen causing salmonellosis in humans and animals. Probiotic Lactobacillus rhamnosus GG (LGG) is an effective strategy for controlling enteric infections through ...
Guiyan Yang (4786875), Jiufeng Wang (1600588), Haifeng Ji (780358), Wei Zhang (405), Jiao Yu (4097278), Yaohong Zhu (6671660), Qiong Wu (84327)   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies [PDF]

Scientific Reports, 2016
AbstractT cells expressing chimeric antigen receptors (CARs) or the infusion of bispecific T-cell engagers (BITEs) have shown antitumor activity in humans for CD19-positive malignancies. While BITEs redirect the large reservoir of resident T cells to tumors, CAR T cells rely on significant in vivo expansion to exert antitumor activity.
Mireya Paulina Velasquez, David Torres, Kota Iwahori, Sunitha Kakarla, Caroline Arber, Tania Rodriguez-Cruz, Arpad Szoor, Challice L. Bonifant, Claudia Gerken, Laurence J. N. Cooper, Xiao-Tong Song, Stephen Gottschalk   +11 more
openaire   +2 more sources

Caracterização imunofenotípica de diferentes linhagens de plasmocitomas murinos utilizadas na produção de anticorpos monoclonais. – [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Anticorpos monoclonais são importantes reagentes utilizados na pesquisa biomédica, em testes de diagnóstico, bem como no tratamento de enfermidades.
Rosa, Elis Amaral
core  

CD34+CD19-CD22+ B-cell progenitors might underlie phenotypic escape in patients treated with CD19-directed therapies

, 2022
CD19-directed immunotherapies have revolutionized the treatment of advanced B-ALL. Despite initial impressive rates of complete remission (CR) many patients ultimately relapse.
Bataller, Alex, Barcena, Paloma, Elliott, Natalina, Trincado, Juan L., Trincado, Juan L, Gutierrez-Agüera, Francisco, Torrebadell, Montserrat, Rovira, Montse, Sole, F, Ribera, Josep María, Ribera, Jose-Maria, Elliot, Natalina, Urbano Ispizua, Álvaro, Roberts, Irene, Orfao, Alberto, Sole, Francesc, Zanetti, S. R, Barrena, Susana, Zanetti, Samanta Romina, Roy, Anindita, Rives, Susana, Menéndez Bujan, Pablo, Menéndez, Pablo, Urbano-Ispizua, Álvaro, Wang, Guanlin, O’Byrne, Sorcha, Mead, Adam J., Mallo, Mar, Mead, Adam J, Bueno, Clara, Juan, Manel, O'Byrne, Sorcha, Thongjuea, Supat, Ribera, Josep-Maria, Psaila, Bethan, Gonzalez, Maria, Trincado Alonso, Juan Luis, 1987-, Vega-García, Nerea, Sorigué, Marc, Torrebadell, Montse, Ortiz-Maldonado, Valentín, Delgado, Julio, Morgades, Mireia, Barrera, Susana, Rovira, Montserrat, Mallo, Maria del Mar, González-González, María   +46 more
core   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

Blood Advances, 2019
: Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the impact of pretreatment variables, such as CD19 expression level, on leukemic
Vinodh Pillai, Kavitha Muralidharan, Wenzhao Meng, Asen Bagashev, Derek A. Oldridge, Jaclyn Rosenthal, John Van Arnam, Jos J. Melenhorst, Diwakar Mohan, Amanda M. DiNofia, Minjie Luo, Sindhu Cherian, Jonathan R. Fromm, Gerald Wertheim, Andrei Thomas-Tikhonenko, Michele Paessler, Carl H. June, Eline T. Luning Prak, Vijay G. Bhoj, Stephan A. Grupp, Shannon L. Maude, Susan R. Rheingold   +21 more
doaj   +1 more source

CAR therapy: the CD19 paradigm [PDF]

Journal of Clinical Investigation, 2015
Twenty-five years after its inception, the genetic engineering of T cells is now a therapeutic modality pursued at an increasing number of medical centers. This immunotherapeutic strategy is predicated on gene transfer technology to instruct T lymphocytes to recognize and reject tumor cells.
openaire   +2 more sources