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CD19 Deficiency Due to Genetic Defects in the CD19 and CD81 Genes
2018CD19 is a transmembrane protein specifically expressed on B cells and acts together with CD21, CD81, and CD225 to reduce the threshold for B-cell antigen receptor (BCR) signaling. To date, 11 patients with childhood-onset hypogammaglobulinemia have been identified with CD19 deficiency due to mutations in the CD19 or CD81 genes.
Menno C. van Zelm, Ismail Reisli
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Immunology Letters, 2017
As a 95-kDa member of the immunoglobulin super-family expressed exclusively on B lymphocytes, CD19 is a critical co-receptor for B cell antigen receptor (BCR) signal transduction. Co-ligation of CD19 with the BCR synergistically enhances calcium release, mitogen-activated protein kinase activity and cell proliferation.
Xinchen, Li +6 more
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As a 95-kDa member of the immunoglobulin super-family expressed exclusively on B lymphocytes, CD19 is a critical co-receptor for B cell antigen receptor (BCR) signal transduction. Co-ligation of CD19 with the BCR synergistically enhances calcium release, mitogen-activated protein kinase activity and cell proliferation.
Xinchen, Li +6 more
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The Journal of Immunology, 1997
Abstract Establishing signal transduction thresholds that regulate B lymphocyte responses to foreign Ags and tolerance to self Ags is critical for humoral immune responses. The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying ...
S, Sato +3 more
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Abstract Establishing signal transduction thresholds that regulate B lymphocyte responses to foreign Ags and tolerance to self Ags is critical for humoral immune responses. The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying ...
S, Sato +3 more
openaire +2 more sources
Blood, 2006
Abstract Current data on the leukemic stem cell (LSC) compartment in childhood acute lymphoblastic leukemia (ALL) are conflicting. The traditional hypothesis supposed that childhood ALL originates in a lymphoid progenitor cell and this is assumed to be consistent with the overall good treatment responses in pediatric patients.
Christoph Le Viseur +8 more
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Abstract Current data on the leukemic stem cell (LSC) compartment in childhood acute lymphoblastic leukemia (ALL) are conflicting. The traditional hypothesis supposed that childhood ALL originates in a lymphoid progenitor cell and this is assumed to be consistent with the overall good treatment responses in pediatric patients.
Christoph Le Viseur +8 more
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CD19 expression is preserved following CD19-directed monoclonal antibody therapy with tafasitamab
BloodAbstract Background: The availability of multiple CD19-targeted agents of different drug classes allows for sequential targeting of the CD19 antigen in relapsed or refractory (R/R) B-cell lymphomas.
Duell, Johannes +10 more
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