Results 141 to 150 of about 106,748 (296)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Elongation factor 1 (EF1alpha) promoter in a lentiviral backbone improves expression of the CD20 suicide gene in primary T lymphocytes allowing efficient rituximab-mediated lysis

Haematologica, 2004
BACKGROUND AND OBJECTIVES: CD20 has been proposed as a novel suicide gene system for the treatment of graft-versus-host disease (GVHD), a fatal complication of allogeneic bone marrow transplantation: indeed expression of the human non-immunogenic ...
M Serafini, M Bonamino, J Golay, M Introna   +3 more
doaj  

Flow Cytometry‐Guided Diagnosis of Cortical T‐Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background T‐cell lymphoblastic lymphoma (T‐LBL) and T‐cell acute lymphoblastic leukemia (T‐ALL) are considered a single biological entity, distinguished primarily by the extent of bone marrow infiltration. This distinction becomes diagnostically challenging in patients with borderline marrow blast counts and predominantly extramedullary ...
Chen Glait‐Santar, Yakir Moshe, Itzhaki‐Alfia Ayelet, Ben‐Zion Katz   +3 more
wiley   +1 more source

Wirkmechanismen CD20-gerichteter Antikörper vom IgA Isotyp [PDF]

, 2018
Ziel dieser Arbeit war es, drei optimierte IgA Moleküle herzustellen, die die variablen Regionen der bereits in der Klinik zugelassenen IgG1 Antikörper Rituximab (RTX), Ofatumumab (Ofa) und Obinutuzumab (Obi) tragen.
Kretschmer, Anna
core  

Flow Cytometric Lymphocyte Subset Enumeration for Lymphopenia Grading and C‐Reactive Protein‐Defined Inflammation Discrimination

Journal of Clinical Laboratory Analysis, EarlyView.
This study refines conventional lymphopenia grading by establishing optimized T‐cell cutoffs via flow cytometric lymphocyte subset profiling. Additionally, by evaluating individual subset performance (CD4+, CD8+, B, and NK cells), the framework integrates these counts to construct predictive models for infection‐associated inflammation.
Shicheng Li, Tingting Fu, Yang Yang, Yuwei Pu, Wenying Yan, Junjun Zhang   +5 more
wiley   +1 more source

Angiosarcoma of the Scalp Presenting With Eyelid Edema: A Diagnostic Pitfall of Eyelid Biopsy

JEADV Clinical Practice, EarlyView.
ABSTRACT Angiosarcoma of the scalp is a rare but aggressive vascular malignancy that may present with nonspecific clinical findings, potentially leading to delayed diagnosis. Eyelid edema is an uncommon initial manifestation and has been suggested to result from direct tumor infiltration or lymphatic obstruction.
Sayo Komiyama, Sayaka Yamaguchi, Akiko Kaneshima, Aya Sunagawa, Shuhei Yonamine, Takuya Miyagi, Teruki Yanagi, Kenzo Takahashi   +7 more
wiley   +1 more source

Subcorneal Pustular Dermatosis, a Systematic Review and Pooled Analysis of a Rare and Underdiagnosed Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, relapsing pustular skin condition of unknown cause, characterised by subcorneal pustules. Objectives To summarise the demographic, clinical, histopathological, management and disease course of SPD.
Mason H. Crossman, Jeffrey Weng, Alysha Vuong, Lawrence Lin, Zhao Feng Liu, Christopher Y. Chew   +5 more
wiley   +1 more source

A Case of Systemic Amyloidosis Diagnosed After Excision of a Cutaneous Tumour of the Buttocks

JEADV Clinical Practice, EarlyView.
ABSTRACT A 72‐year‐old Japanese man was referred to our hospital with two tumours on the buttocks. Two solitary, 2.5 × 1.5 cm‐sized, dark brown, well‐demarcated elevated plaques were observed, one on each side of the gluteal cleft, and dermoscopic examination showed comedo‐like openings, multiple milia‐like cysts, and a cerebriform pattern with ...
Tomomichi Shimizu, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Akio Kondo, Fumikazu Yamazaki, Yohei Masugi, Tomotaka Mabuchi   +9 more
wiley   +1 more source

P106 | Cd20 positive multiple myeloma: is it a different entity?

Haematologica
Introduction. Expression of CD20 antigen is generally negative in patients (pts) with multiple myeloma (MM). However, a small number of MM pts (15-20%) can show CD20 positivity on neoplastic plasma cells (PC).
Monica Poscente
doaj  

Detecting CD20-Rituximab interaction forces using AFM single-molecule force spectroscopy

, 2011
原子力显微镜(AFM)的发明为测量分子间特异性相互作用力提供了新的技术手段.利用AFM单分子力谱(SMFS)技术分别测量了提纯的CD20,淋巴瘤Raji细胞表面的CD20和淋巴瘤病人B细胞表面的CD20与Rituximab(抗CD20单克隆抗体)之间的相互作用力.通过探针功能化技术,将Rituximab连接到AFM针尖; 通过基底功能化技术,将提纯的CD20分子吸附到云母表面,对CD20分子进行了AFM成像,并测量了CD20与Rituximab之间的相互作用力; 通过静电吸附和化学固定 ...
肖秀斌, 张伟京, 李密, 刘连庆, 王越超, 李广勇, 董再励   +6 more
core