Results 91 to 100 of about 7,097 (193)
Scientific Reports, 2021 This study was conducted to investigate the impact of genetic variants of immune checkpoint genes on the treatment outcome in small cell lung cancer (SCLC). In the present study, 261 platinum doublet-treated SCLC patients were enrolled.
Jang Hyuck Lee +18 more
doaj +1 more source
Involvement of CD226+ NK Cells in Immunopathogenesis of Systemic Lupus Erythematosus [PDF]
The Journal of Immunology, 2011 Abstract Dysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mechanisms behind this decrease and
Zhan, Huang +6 more
openaire +2 more sources
mSphere, 2017 Epstein-Barr virus (EBV), an oncogenic herpesvirus, infects and transforms primary B cells into immortal lymphoblastoid cell lines (LCLs), providing a model for EBV-mediated tumorigenesis.
Lisa Grossman +6 more
doaj +1 more source
HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation [PDF]
, 2018 Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo ...
Fielding, Ceri A. +5 more
core +3 more sources
Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy
Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley +1 more source
Increased levels of circulating soluble CD226 in multiple sclerosis
Multiple Sclerosis JournalBackground: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown.
Kari, Saniya +15 more
openaire +3 more sources
International Journal of Genomics, Volume 2026, Issue 1, 2026.Background Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management.
Hua Xu +9 more
wiley +1 more source
CD226 deficiency improves cognitive functions and ameliorates anxiety‐like behaviors in mice [PDF]
Brain and Behavior, 2017 AbstractBackgroundCD226 is a cell surface adhesion molecule expressed in the immune system and central nervous system. Although the role of CD226 in the function of immune cells has been well studied, there has been no report on the potential functional significance of CD226 in neural cells.MethodsWe investigated the role of CD226 on the cognitive ...
Liang Fang +7 more
openaire +2 more sources
Scientific Reports, 2021 CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of soluble CD226 (sCD226) in SLE is still ...
Miki Nakano +13 more
doaj +1 more source
Memory NK cell features exploitable in anticancer immunotherapy [PDF]
, 2019 Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone +5 more
core +2 more sources