Results 161 to 170 of about 152,273 (295)

Diagnosing Systemic Mastocytosis: State of the Art

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

CD25, lösliches [PDF]

, 2019
openaire   +1 more source

IL‐1β and IL‐6 synergistically drive murine TFH cell differentiation and maintenance in vitro

Immunology &Cell Biology, EarlyView.
We define a physiologically relevant in vitro system that demonstrates the combined function of T‐cell receptor signaling, IL‐6 and IL‐1β individually and jointly to promote TFH cell differentiation. These findings identify the essential requirements for generating functional TFH cells and clarify how cytokines shape their differentiation within the ...
Juliana Restrepo Munera, S Rameeza Allie
wiley   +1 more source

Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy

Immunology &Cell Biology, EarlyView.
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong, Fernando Souza‐Fonseca‐Guimaraes   +1 more
wiley   +1 more source

Bone marrow and splenic immune composition is unperturbed by short-term exposure to bedding from pet store mice. [PDF]

Immunohorizons
Little-Letsinger SE, Karmaus PWF, Fessler MB, Hamilton SE.   +3 more
europepmc   +1 more source

Иммунорегуляторные cd25+cd4+ Т-клетки

Российский биотерапевтический журнал, 2006
Naturally occurring CD25+CD4+ regulatory T-cells (Treg) play crucial role in negative control of host immune response in tumor growth, in allergy, transplantation, infection diseases. In review we present characteristics of main phenotypes markers and functional properties of Treg.
openaire   +1 more source

Immune checkpoint inhibitor cardiomyotoxicity: a case series of five patients and development of a clinical management algorithm

Internal Medicine Journal, EarlyView.
Abstract Immune checkpoint inhibitor (ICI) therapies have revolutionised the management of a range of malignancies. However, the syndrome of ICI induced cardiomyotoxicity, also reported as triple “M” syndrome (myasthenia gravis, myositis and myocarditis) is an unfortunate severe consequence in up to 1%–2% of patients receiving ICI, with an associated ...
S. Z. Xie, J. E. Salem, A. Nagrial, A. Menzies, L. Thomas, S. Ramanathan, L. J. Berglund, S. C. Sasson, A. C. Grey, R. Habib, M. Wong, M. S. Carlino, B. Jeffrey, J. Mo, M. W. Lin   +14 more
wiley   +1 more source

TGF-β-induced Tregs release extracellular vesicles that modulate CD4+ T-cell proliferation and phenotype in a Nrp1-dependent manner. [PDF]

Immunohorizons
Moya-Guzmán MJ, González-Mienert E, Pinto C, Pino-Lagos K.   +3 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

CD25 modulation enhances broadly neutralizing antibody response of SARS-CoV-2 subunit vaccine. [PDF]

Commun Biol
Li F, Yu X, Zhang C, Liu W, Tian H, Wang X, Wang P, Yu B, Yu X.   +8 more
europepmc   +1 more source