Results 1 to 10 of about 139,988 (286)

Interleukin‐1 receptor antagonist, interleukin‐2 receptor alpha subunit and amyotrophic lateral sclerosis [PDF]

European Journal of Neurology, 2020
Background and purposeTo clarify the causal associations of interleukin‐1 receptor antagonist (IL‐1ra) and interleukin‐2 receptor alpha subunit (IL‐2rα) with the risk of amyotrophic lateral sclerosis (ALS).MethodsA two‐sample Mendelian randomization study design was employed. Single‐nucleotide polymorphisms associated with IL‐1ra (n = 2) and IL‐2rα (n =
S. Yuan, P. M. Roos, S. C. Larsson
openaire   +5 more sources

Proteome‐Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Finding effective and safe therapeutic drugs for atrial fibrillation (AF) is an important concern for clinicians. Proteome‐wide Mendelian randomization analysis provides new ideas for finding potential drug targets. Methods and Results Using a
Xinpei Wang, Tao Huang, Jinzhu Jia
doaj   +1 more source

Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination

Animals, 2023
This study aims to identify the immune-related genes and the corresponding biological pathways following infectious bronchitis virus vaccination in Taiwan Country and White Leghorn chicken breeds. Transcriptomic analyses of the spleen of these two breeds
Schwann Chuwatthanakhajorn, Chi-Sheng Chang, Kannan Ganapathy, Pin-Chi Tang, Chih-Feng Chen   +4 more
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Interleukin-2 mutants with enhanced  -receptor subunit binding affinity [PDF]

Protein Engineering Design and Selection, 2003
Stimulation of T-cells by IL-2 has been exploited for treatment of metastatic renal carcinoma and melanoma. However, a narrow therapeutic window delimited by negligible stimulation of T-cells at low picomolar concentrations and undesirable stimulation of NK cells at nanomolar concentrations hampers IL-2-based therapies.
Balaji M, Rao, Andrew T, Girvin, Thomas, Ciardelli, Douglas A, Lauffenburger, K Dane, Wittrup   +4 more
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Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits. [PDF]

Proceedings of the National Academy of Sciences, 1994
The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed cooperative interactions between the IL-2R alpha and beta chains (IL-2R alpha and IL-2R beta, respectively) in COS cells transfected with cDNAs encoding the IL-2R ...
E, Roessler, A, Grant, G, Ju, M, Tsudo, K, Sugamura, T A, Waldmann   +5 more
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Recent Advances in IL-13Rα2-Directed Cancer Immunotherapy

Frontiers in Immunology, 2022
Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid tumors and is correlated with poor prognosis in glioblastoma, colorectal ...
Karin M. Knudson, SuJin Hwang, Mondona S. McCann, Bharat H. Joshi, Syed R. Husain, Raj K. Puri   +5 more
doaj   +1 more source

Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor. [PDF]

The Journal of experimental medicine, 1987
In this report, we have investigated the kinetics of IL-2 binding to the alpha (p55) and beta (p70) IL-2 binding proteins and compared these properties with ligand binding to the high-affinity IL-2-R. The association and dissociation of IL-2 to the alpha (p55) chain occurred with very rapid kinetics (t 1/2 = 4-10 s).
J W, Lowenthal, W C, Greene
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Functional proteomic analysis of Ankaferd® Blood Stopper

Turkish Journal of Hematology, 2010
OBJECTIVE: Ankaferd® Blood Stopper (ABS) comprises a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. The basic mechanism of action for ABS is the formation of an encapsulated
Duygu Özel Demiralp, İbrahim C. Haznedaroglu, Nejat Akar   +2 more
doaj   +3 more sources

Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before fertilization and embryo transfer [PDF]

Obstetrics & Gynecology Science, 2023
Objective This study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET).
Sung Pil Choo, Inha Lee, Jae-Hoon Lee, Dowon Lee, Hyemin Park, Joo Hyun Park, SiHyun Cho, Young Sik Choi   +7 more
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