Results 201 to 210 of about 142,249 (285)

The race between 4-1BB- and CD28-based CD19 CAR-T products in the therapy of B-cell malignancies.

Biochim Biophys Acta Rev Cancer
Krawczyk M, Drużyńska M, Bednarska E, Winiarska M.   +3 more
europepmc   +1 more source

CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters. [PDF]

Commun Biol
Nishikawa T, Takeuchi A, Machiyama H, Wakamatsu E, Nishijima H, Furuhata M, Toyota H, Nishi W, Matsushima R, Yoshida Y, Harada K, Yokosuka T.   +11 more
europepmc   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. [PDF]

ACS Omega
Calvo-Barreiro L, Nada H, Upadhyay S, Gabr MT.   +3 more
europepmc   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity. [PDF]

Cancer Immunol Immunother
Yokomura M, Nagano S, Kawamoto H, Hirohashi Y, Torigoe T, Asakage T, Katayama R.   +6 more
europepmc   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Immune landscape and biomarker identification in Q fever: a comprehensive diagnostic analysis. [PDF]

PLoS One
Gong Z, Liu S.
europepmc   +1 more source

CD28 augments phosphoinositide turnover [PDF]

Arthritis Research & Therapy, 2001
openaire   +1 more source