Results 71 to 80 of about 107,086 (298)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

SKIN ALLOGRAFT REJECTION IN CD28-DEFICIENT MICE1

, 1996
Costimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general. To further assess the importance of the costimulatory signals generated through CD28, the allogeneic response was examined in CD28-deficient
Kazuhiro Kawai, Kawai, Kazuhiro, Shahinian, Arda, Mak, Tak W., Ohashi, Pamela S., Tak W. Mak, Pamela S. Ohashi, Arda Shahinian   +7 more
core   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Evaluation of Some Immunological Markers in Pregnant Women Infected with Cytomegalovirus in Kirkuk, Iraq

Medical Journal of Babylon
Background: Both innate and adaptive immunological responses may be activated by cytomegalovirus (CMV) infection, leading to significant reactions later in the course of the illness. Innate immune components, which react fast and nonspecifically, combine
Zena Muayad Nooruldeen, Mohammed Yawoz Nooruldeen   +1 more
doaj   +1 more source

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo

International audienceNaive T cell activation requires both TCR and CD28 signals. The CARMIL2 cytosolic protein enables CD28-dependent activation of the NF-κB transcription factor via its ability to link CD28 to the CARD11 adaptor protein.
Mellado, Valentin, Vilarnau Wolek, Carine, Celis-Gutierrez, Javier, Burlet-Schiltz, Odile, Malissen, Bernard, Voisinne, Guillaume, Roncagalli, Romain, Mori, Daiki, Mello, Marielle, Malissen, Marie, Panigot, Sophie, Gelard, Léna, Fiore, Frédéric, Liang, Yinming, Zhang, Lichen, Gonzalez de Peredo, Anne, Lu, Liaoxun, Zhang, Fanghui   +17 more
core   +1 more source

CD28 signals through acidic sphingomyelinase.

, 1995
T cell receptor recognition of antigen can lead either to T lymphocyte differentiation and proliferation or to a state of unresponsiveness, which is dependent on whether appropriate costimulatory signals are provided to the mature T cell.
L M Boucher, T W Mak, K Wiegmann, A Fütterer, Krönke, Martin, Fütterer, Agnes, Pfeffer, Klaus, Machleidt, Thomas, K Pfeffer, Wiegmann, Katja, S Schütze, Mak, Tak W., T Machleidt, M Krönke, Boucher, Louis Martin, Schtitze, Stefan   +15 more
core   +1 more source

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

, 2020
Background Acute myeloid leukemia (AML) is a hematopoietic malignancy which is biologically, phenotypically and genetically very heterogeneous. Outcome of patients with AML remains dismal, highlighting the need for improved, less toxic therapies ...
Menéndez, Pablo, Libero Baroni, Matteo, Anguita Mandly, Eduardo Luis   +2 more
core   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Mesenchymal stem cells control alloreactive CD8(+)CD28(-) T cells

, 2013
CD28/B7 co-stimulation blockade with belatacept prevents alloreactivity in kidney transplant patients. However, cells lacking CD28 are not susceptible to belatacept treatment.
Hoogduijn, Martin, Weimar, Willem, Betjes, M.G.H., Litjens, Nicolle, Engela, AU, Baan, Carla, Franquesa, Marcella   +6 more
core   +2 more sources

The effects of interleukin-10 or TGF-beta on anti-CD3/CD28 induced activation of CD8+CD28- and CD8+CD28+ T cells in allergic asthma

, 2013
The CD8+CD28- and CD8+CD28+ T cells play a primordial role in peripheral tolerance, but little is known about their implication in allergic asthma. This study was designed to determine the changes in a proportion of human circulatory CD8+ subsets before ...
Eusebio, M., Kupczyk, M., Pietruczuk, M., Kraszula, L., Kuna, P.   +4 more
core   +1 more source