Results 61 to 70 of about 228,118 (255)
Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28
, 2017 International audienceSystemic lupus erythematosus (SLE) is a chronic systemic inflammatory disease. Autoan-tibodies (autoAbs) against double-stranded DNA (ds DNA), the hallmark of lupus, are produced and maintained by the interaction between auto ...Poirier, Nicolas, Moreau, A., Vanhove, B., Mary, C., Laurent, L., Fakhouri, F., Awena Le Fur, Fakhouri, Fadi, Anne Moreau, Le Fur, Awena, Bloas, R. L., Mary, Caroline, Laurent, Laetitia, Neel, M., Le Bloas, Rozenn, Laetitia Laurent, Poirier, N., Vanhove, Bernard, Fadi Fakhouri, Moreau, Anne, Néel, Mélanie, Rozenn Le Bloas, Le Fur, A., Nicolas Poirier, Bernard Vanhove, Mélanie Néel, Caroline Mary +26 morecore +1 more sourceModulation of the Bovine Delayed-Type Hypersensitivity Responses to Defined Mycobacterial Antigens by a Synthetic Bacterial Lipopeptide [PDF]
, 2003 The use of defined protein and peptide antigens can overcome specificity limitations of purified protein derivatives in the detection of bovine tuberculosis when the antigens are used in blood-based tests. Since the use of these specific antigens as skin Howard, CJ, Hewinson, R. G., Vordermeier, H.M., Clifford, D., Hope, Jayne; id_orcid, Whelan, A O +5 morecore Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy
Advanced Science, EarlyView.A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu +9 morewiley +1 more sourceCD4+ T cell proliferation following incubation of purified CD4+ T cells with different antigens, plus IL-2, anti-CD3 and anti-CD28.
, 2016 CD4+ T cell proliferation following incubation of purified CD4+ T cells with different antigens, plus IL-2, anti-CD3 and anti-CD28.Muhammad Saleem (377032), Manish Sadarangani (111484), Susan Lewis (2625226), Jeremy P. Derrick (136524), Claire Jones (111487), Isabelle Payne (2625223), Andrew J. Pollard (44971) +6 morecore +1 more sourceAnalysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]
, 2013 BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...Kaufmann, S.H.E., Ambrose, Lyn R., Gomez, M., Martin Ota (198869), Lalor, M., Donkor Simon, Novel N Chegou, Kees Franken, Willem Hanekom (23103), Gerhard Walzl (149313), Mihret, A., Crampin, Amelia C, Simon Donkor (343534), Parida, S., Thiel Bonnie A., Hazel M Dockrell, Hanekom, Willem, GCGH Biomarkers for TB consortium, Amelia C Crampin, Parida, Shreemanta K., Kassa, Desta, Loxton, Andre G., Gomez, M.P., Martin Ota, Crampin, Amelia C., Loxton, Andre G, Rawleigh Howe (456745), Hanekom Willem, Parida Shreemanta K., W. Henry Boom (125099), Simon Donkor, Lalor, Maeve K., Ambrose, Lyn R, Andre G. Loxton (160294), Howe Rawleigh, Dockrell Hazel M., Kassa Desta, Gomez, Marie P., Boom, W. Henry, Sutherland, Jayne S, Franken Kees, Ota, Martin, Stefan H E Kaufmann, GCGH Biomarkers TB Consortium, Stefan H. E. Kaufmann (149315), Walzl, G., Crampin, A.C., Mayanja-Kizza Harriet, Sutherland, Jayne S., Michel R. Klein (160302), Lalor Maeve K., Black, Gillian F, Chegou Novel N., Black, G., Harriet Mayanja-Kizza (78637), Donkor, S., Maeve K Lalor, Gomez Marie P., Boom, W.H., Donkor, Simon, Kassa, D., Loxton, A.G., Kees Franken (456747), Amelia C. Crampin (239427), Ambrose, L.R., Desta Kassa (456743), Crampin, A., Black, Gillian F., Thiel, Bonnie A., Ambrose Lyn R., Dockrell, Hazel M., Lyn R Ambrose, Adane Mihret, Hazel M. Dockrell (255469), Klein Michel R., Parida, Shreemanta K, Franken, K., Dockrell, H.M., Walzl Gerhard, Kaufmann, Stefan H.E., Boom, W Henry, Shreemanta K. Parida (149299), Klein, Michel R., Chegou, Novel N, Klein, M.R., Bonnie A Thiel, Lyn R. Ambrose (456742), Ota Martin, Thiel, B.A., Andre G Loxton, Sutherland, J., Shreemanta K Parida, Harriet Mayanja-Kizza, Ottenhoff Tom H. M., Ota, M., Loxton, A., Howe, R., Mayanja-Kizza, H., Ottenhoff, Tom HM, Tom H M Ottenhoff, Cardona, Pere-Joan, Ottenhoff, T.H.M., Willem Hanekom, Crampin Amelia C., Gomez, Marie P, Novel N. Chegou (160288), Chegou, Novel N., Klein, M., Sutherland, J.S., Lalor, M.K., Thiel, Bonnie A, Bonnie A. Thiel (456748), Maeve K. Lalor (356874), Ottenhoff, T., Walzl, Gerhard, Gillian F. Black (149301), Boom W. Henry, Ambrose, L., Hanekom, W., Marie P Gomez, Lalor, Maeve K, Adane Mihret (456744), Chegou, N.N., Marie P. Gomez (456746), Jayne S Sutherland, Sutherland Jayne S., Klein, Michel R, Chegou, N., Jayne S. Sutherland (334202), Kaufmann, Stefan HE, Parida, S.K., Mihret Adane, Kaufmann Stefan H. E., Ottenhoff, Tom H.M., W Henry Boom, Rawleigh Howe, Thiel, B., Gerhard Walzl, Tom H. M. Ottenhoff (160303), Gillian F Black, Dockrell, H., Black Gillian F., Howe, Rawleigh, Boom, W., Black, G.F., Loxton Andre G., Desta Kassa, Ottenhoff, Tom H M, Kaufmann, S., Mihret, Adane, Franken, Kees, Mayanja-Kizza, Harriet, Michel R Klein, Kaufmann, Stefan H E, Dockrell, Hazel M +154 morecore +3 more sourcesAARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema
Advanced Science, EarlyView.Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu +12 morewiley +1 more sourceEnhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location
Frontiers in Immunology, 2020 CD4 T cell memory is fundamental for long-lasting immunity and effective secondary responses following infection or vaccination. We have previously found that memory CD4 T cells specific for systemic antigens preferentially reside in the bone marrow (BM) Jana Sarkander, Shintaro Hojyo, Mathias Mursell, Yuzuru Yamasaki, Tsung-Yen Wu, Damon J. Tumes, Kosuke Miyauchi, Cam Loan Tran, Jinfang Zhu, Max Löhning, Max Löhning, Andreas Hutloff, Mir-Farzin Mashreghi, Masato Kubo, Masato Kubo, Andreas Radbruch, Koji Tokoyoda +16 moredoaj +1 more sourceGM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao +13 morewiley +1 more sourceCD8+CD28+ and CD8+CD28- T lymphocytes in HIV infection: Correlation with other parameters
, 1994 The aim of the present work was the study of the expression of CD28 antigen in CD8+ Τ lymphocytes in relation with the expression of antigens .CDllb, CD45RO, CD38, HLA-DR, CD25 as well as with the detection of soluble receptors (sCD8, sIL-2R), and the ...Viglis, Vassilis, Βιγκλής, Βασίλειος +1 morecore +1 more source
