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Modulation of MHC class I expression by African swine fever virus and the role of virus proteins EP153R and CD2v

, 2014
Various DNA viruses, including pox- and herpesviruses, express proteins which down-regulate host MHC class I antigen expression as an immune evasion strategy. Previous studies into whether ASFV modulates expression of the porcine MHC class I molecule, SLA I, have not provided a clear answer. In this thesis, the effect of African swine fever virus (ASFV)
openaire   +3 more sources

Towards Safe African Swine Fever Vaccines: The A137R Gene as a Tool to Reduce Virulence and a Promising Serological DIVA Marker Candidate

Animals
African swine fever (ASF) is an emerging disease caused by the African swine fever virus (ASFV), which is a great threat to the swine industry worldwide.
Andrey Koltsov, Mikhail Sukher, Sergey Krutko, Sergey Belov, Alexey Korotin, Sofia Rudakova, Sergey Morgunov, Galina Koltsova   +7 more
doaj   +1 more source

Development of Adenovirus-vectored Prototype Vaccines for African Swine Fever Virus and Bovine Viral Diarrhea Virus [PDF]

, 2017
The objective of this work was to develop adenovirus-vectored prototype vaccines against two pathogens, African Swine Fever Virus (ASFV) and Bovine Viral Diarrhea Virus (BVDV), which cause disease in two major livestock species, swine and cattle ...
Lokhandwala, Shehnaz Taher
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Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate

npj Vaccines
A modified live attenuated African swine fever genotype II virus, GΔDKE-CmutQ96R/K108D, with deletions of three genes, DP148R, EP153R, and K145R and expressing a mutated CD2v protein with a non-haemadsorbing phenotype, was further modified by first ...
Anusyah Rathakrishnan, Ana Luisa Reis, Katy Moffat, Lynnette Goatley, Elisenda Viaplana, Jose Carlos Mancera, Alicia Urniza, Linda K. Dixon   +7 more
doaj   +1 more source

How Does African Swine Fever Virus Evade the cGAS-STING Pathway?

Pathogens
African swine fever (ASF), a highly infectious and devastating disease affecting both domestic pigs and wild boars, is caused by the African swine fever virus (ASFV). ASF has resulted in rapid global spread of the disease, leading to significant economic
Can Lin, Chenyang Zhang, Nanhua Chen, François Meurens, Jianzhong Zhu, Wanglong Zheng   +5 more
doaj   +1 more source

African swine fever: advances and challenges [PDF]

African swine fever (ASF) has become a major focus of research after spreading to four continents besides Africa. In its natural African ecosystem, the causative ASF virus (ASFV) is maintained by indigenous Suidae as natural reservoirs and hard tick ...
Blome, S., Mettenleiter, T.C., Williams, D.T.   +2 more
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Modulation of MHC class I expression by African swine fever virus and the role of virus proteins EP153R and CD2v

, 2016
Various DNA viruses, including pox- and herpesviruses, express proteins which downregulate host MHC class I antigen expression as an immune evasion strategy. Previous studies into whether ASFV modulates expression of the porcine MHC class I molecule, SLA-I, have not provided a clear answer. In this thesis, the effect of African swine fever virus (ASFV)
openaire   +1 more source

Emerg Infect Dis [PDF]

African swine fever is widespread in Africa but has occasionally been introduced into other continents. In June 2007, African swine fever was isolated in the Caucasus Region of the Republic of Georgia and subsequently in neighboring countries (Armenia ...

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Evaluation and comparison of African swine fever virus and vaccinia virus cell entry pathways [PDF]

Doctor of PhilosophyDepartment of Diagnostic Medicine/PathobiologyRaymond R. R. RowlandAfrican swine fever virus (ASFV) causes a highly contagious and deadly disease in swine, with severe economic consequences.
Olcha, Matthew Evan
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Characterization of recombinant Modified Vaccinia virus Ankara delivering African swine fever virus proteins [PDF]

, 2023
Erlbeck, Lia
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