Results 211 to 220 of about 389,148 (301)

The FAP × CD3 bispecific antibody OMTX305 induces T cell-mediated antitumor effects in patient-derived ex vivo models of solid tumors. [PDF]

Sci Adv
Thiel J, Schlegel JA, Liang C, Mürdter TE, Kneer A, Dreher S, Schäfer A, Seifert O, Kühl L, Preissler G, Simon L, Fabre M, Egaña I, Kurz KS, Ott G, Kontermann RE, Aulitzky WE, Schwab M, Olayioye MA, Dong M.   +19 more
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

New England Journal of Medicine, 2005
B. Keymeulen, E. Vandemeulebroucke, A. Ziegler, C. Mathieu, L. Kaufman, G. Hale, F. Gorus, M. Goldman, M. Walter, S. Candon, L. Schandené, L. Crenier, C. D. De Block, J. Seigneurin, P. De Pauw, D. Piérard, I. Weets, P. Rebello, P. Bird, E. Berrie, M. Frewin, H. Waldmann, J. Bach, D. Pipeleers, L. Chatenoud   +24 more
semanticscholar   +1 more source

Effects of preterm birth and gestational diabetes on innate lymphoid cells (ILCs) in human breast milk. [PDF]

Mol Cell Pediatr
Raché M, Lükewille L, Vogelgesang A, Lange A, Ittermann T, Heckmann M, Ruhnau J.   +6 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Analysis of peripheral blood T-cell levels for predicting immunotherapy response sensitivity in squamous cell carcinoma of the head and neck. [PDF]

Front Mol Biosci
Li N, Feng L, Yin G, Ding S, Guo W.
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

CD28 and CD3 have complementary roles in T-cell traction forces

Proceedings of the National Academy of Sciences of the United States of America, 2014
Keenan T. Bashour, A. Gondarenko, Hao-Qian Chen, K. Shen, Xin Liu, M. Huse, J. Hone, L. Kam   +7 more
semanticscholar   +1 more source

Prognostic and Predictive Value of Peripheral CD8/PD-1/TCF-1 Positive T Cells in Non-Small Cell Lung Carcinoma Patients. [PDF]

Immunotargets Ther
Xagara A, Goulielmaki M, Chantzara E, Koinis F, Fortis SP, Hatzidaki D, Ntostoglou K, Christodoulopoulos G, Saloustros E, Karagiannis SN, Frisan T, Baxevanis CN, Georgoulias V, Pateras IS, Kotsakis A.   +14 more
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source