Advanced Science, EarlyView.A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee +9 more
wiley +1 more source
Spatial T lymphocyte infiltration into the primary melanoma tumor associates with survival. [PDF]
Melanoma ResEdmiston SN +10 more
europepmc +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Peripheral immune dynamics during treatment predict prognosis in HCC receiving TACE plus ICIs and anti-VEGF/TKIs. [PDF]
Clin Transl ImmunologyQin L +6 more
europepmc +1 more source
An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer
Advanced Science, EarlyView.Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li +11 more
wiley +1 more source
The impairment of CD3+ T lymphocytes in sentinel lymph node of high-risk cutaneous melanoma patients in stage IIB and IIC. [PDF]
J Pathol Transl MedFilipović E +7 more
europepmc +1 more source
TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
Lymphocytic Variant Hypereosinophilic Syndrome Overlaps with Angioimmunoblastic T-Cell Lymphoma: A Case Report and Literature Review. [PDF]
Eur J Case Rep Intern MedBelfeki N +3 more
europepmc +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
Comprehensive immune profiling of human peripheral blood mononuclear cells using two complementary spectral flow cytometry panels encompassing 60 unique markers. [PDF]
Front ImmunolRietdijk MH +5 more
europepmc +1 more source