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CD36 expression and brain function: does CD36 deficiency impact learning ability?
Prostaglandins & Other Lipid Mediators, 2005This article first presents an overview of published literature documenting the role of the scavenger receptor CD36 in activation of brain microglia with reference to brain pathologies such as Alzheimer's and malaria. Second, the possibility that CD36 may play a role in brain FA metabolism is discussed.
Mohammad Ajmal +3 more
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CD36 and malaria: friends or foes?
Trends in Parasitology, 2003Past research efforts examining the adhesive characteristics of Plasmodium falciparum-infected erythrocytes have focused primarily on sequestration in the peripheral circulation. Recent work has begun to elucidate how these adhesive phenotypes can also modulate host response to infection and how host–parasite interactions might be exploited to improve ...
Samir N. Patel +3 more
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The Function of CD36 in Tumorigenesis
2022During matrix detachment, tumor cells grow as multicellular clusters, and metabolism in this setting has been shown to recapitulate early stages of tumorigenesis. We previously found that detached cells activate AMPK to inhibit fatty acid synthesis and induce fatty acid oxidation, which raises the question of how clustered cells maintain the integrity ...
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Genetics of Cd36 and the hypertension metabolic syndrome
Seminars in Nephrology, 2002Although genetic mapping of quantitative trait loci (QTL) for complex traits related to hypertension is relatively straightforward, the identification of QTL at the molecular level has proven far more difficult. By combining techniques of gene mapping and gene expression profiling with studies in congenic and transgenic strains, a specific molecular ...
Michal Pravenec, Theodore W. Kurtz
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CD36 A critical anti angiogenic receptor
Frontiers in Bioscience, 2003Thrombospondin-1 (TSP-1) is a potent inhibitor of angiogenesis in vivo and of microvascular endothelial cell responses to angiogenic factors in vitro. CD36 is the cellular receptor for TSP-1 on microvascular endothelium and is necessary for its anti-angiogenic activity.
Ronit Simantov, Roy L. Silverstein
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Pathophysiology of Human Genetic CD36 Deficiency
Trends in Cardiovascular Medicine, 2003CD36, originally identified as glycoprotein IV on platelets, is an 88-kDa integral membrane protein that has multiple ligands and is expressed in the cardiovascular system (ie, blood vessel walls and the heart). Human genetic CD36 deficiency is relatively frequent in Asian and African populations. Investigation into the pathophysiology of this disorder
Ken-ichi Hirano +5 more
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CD36 Deficiency Suppresses Epileptic Seizures
Neuroscience, 2017Cluster of differentiation 36 (CD36) belongs to the class B scavenger receptor family. CD36 is a glycoprotein found on the surface of various cell types and has been implicated in the mechanism of numerous central nervous system (CNS) diseases. However, the relationship between CD36 and epilepsy remains unknown.
Xin Xu +9 more
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CD36 Neuronal Identity in the Olfactory Epithelium
2018CD36 scavenger receptor is expressed in a subpopulation of olfactory sensory neurons (OSNs). These neurons express canonical olfactory signaling machinery; however, not all odorant receptors (ORs) are coexpressed with CD36. In situ hybridization (ISH) enables the detection of nucleic acids in tissues, cells, or isolated chromosomes.
André Machado Xavier, Isaias Glezer
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Current Opinion in Clinical Nutrition & Metabolic Care, 2006
Philip C. Calder, Richard J. Deckelbaum
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Philip C. Calder, Richard J. Deckelbaum
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