Results 301 to 310 of about 83,609 (361)

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

Experimental Physiology, Volume 110, Issue 8, Page 1071-1086, 1 August 2025.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, Philip D. Whitfield, George D. Mcilroy, Justin J. Rochford, Nimesh Mody   +8 more
wiley   +1 more source

Spatiotemporal Super‐Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao, Qihang Ding, Caixia Sun, Borbala Codogno, Zhiqiang Liu, Xiaoqiang Yu, Jong Seung Kim, Kang‐Nan Wang   +7 more
wiley   +2 more sources

HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages [PDF]

, 2003
James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Richard N. Greenberg, Theresa M. Guerin, David Meade, Xiang‐An Li, Weifei Zhu, Annette Uittenbogaard, Melinda E. Wilson, Eric J. Smart   +11 more
openalex   +1 more source

The mechanobiology of extracellular matrix: a focus on thrombospondins. [PDF]

Cell Commun Signal
Zhao Y, Lei T, Ge X, Fan L, He Y, Yu Z, Hu S.   +6 more
europepmc   +1 more source

Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice

Physiological Reports, Volume 13, Issue 15, August 2025.
Abstract The association between metabolic dysfunction–associated steatotic liver disease (MASLD) and cardiovascular disease is well characterized; however, the underlying mechanism is incompletely understood. Interestingly, hepatocyte‐specific silencing of dipeptidyl peptidase 4 (DPP4) prevents liver fibrosis and adipose tissue inflammation; however ...
Natasha A. Trzaskalski, Melissa M. Dann, Antonio Hanson, Branka Vulesevic, Evgenia Fadzeyeva, Natasha Jeraj, Ilka Lorenzen‐Schmidt, Rick Seymour, Erin E. Mulvihill   +8 more
wiley   +1 more source

Exploring the Association Between <i>CD36</i> rs1761667 Polymorphism and Susceptibility to Non-Contact Tissue Injuries in Moroccan Elite Cyclists and Field Hockey Players: A Pilot Study. [PDF]

Genes (Basel)
El Ouali EM, Kartibou J, Del Coso J, El Makhzen B, Bouguenouch L, El Akbir R, El Haboussi A, Akhouayri O, Ibrahimi A, Mesfioui A, Zouhal H.   +10 more
europepmc   +1 more source

Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy

Physiological Reports, Volume 13, Issue 15, August 2025.
Abstract Pregnancy demands increased food intake and nutrient delivery to support the growing conceptus. The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear. We therefore assessed anatomy and expression of macronutrient transporters in the duodenum, jejunum,
T. Sebastian Overduin, Georgia S. Clarke, Hui Li, Richard L. Young, Kathryn L. Gatford, Amanda J. Page   +5 more
wiley   +1 more source

Wnt Activation in Mature Dermal Adipocytes Leads to Lipodystrophy and Skin Fibrosis via ATGL‐Dependent Lipolysis

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
We report the first tractable and reversible Wnt activation model in dermal adipocytes in mouse skin. Our findings demonstrate that sustained Wnt activation in mature dermal adipocytes leads to lipodystrophy, which is sufficient to induce skin fibrosis in vivo.
Qiannan Ma, Ella X. Segal, Miles A. Montegut, Suneeti R. Madhavan, Anna R. Jussila, Claire Reynolds, Rachel H. Wyetzner, Megan Gregory, Elif Ertugral, Chandrasekhar Kothapalli, Radhika P. Atit   +10 more
wiley   +1 more source

Active peptides of TSP-1 inhibit retinal angiogenesis through the CD36 pathway in a rat model of choroidal neovascularization. [PDF]

PLoS One
Li Y, Deng A, Jiao K, Yan J, Zuo W, Dong Y, Xu W, Li Y, Guo C, Chen M, Tian R, Hu Z.   +11 more
europepmc   +1 more source

Genetic and Functional Dissection of the NFKB2 Gene: Implications for Milk Fatty Acid Biosynthesis in Dairy Cattle

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
In this study, NFKB2 was verified to have a significant genetic effect on FAs. Knockdown of NFKB2 significantly reduced triglyceride concentrations, lipid droplet secretion, and the expressions of 17 key genes involved in lipid metabolism pathways, including PI3K‐AKT, NF‐κB, MAPK, adipocytokine, PPAR, and AMPK signaling pathways.
Lijun Shi, Zijiao Guo, Nan Shen, Cong Li, Bo Han, Dongxiao Sun   +5 more
wiley   +1 more source