Results 341 to 350 of about 83,609 (361)

Harnessing CD36 to Rein in Inflammation

Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2008
Maintaining health requires a dynamic balance between the influence of pro-inflammatory and anti-inflammatory mediators. While inflammation serves an important protective role against infection, unrestrained inflammation is acutely lethal and unresolved inflammation contributes to a broad range of chronic disorders.
L. Barrett, Matthew S. Parsons, Michael D. Grant, C. Little   +3 more
openaire   +3 more sources

Frequency of CD36 deficiency in Thais analyzed by quantification of CD36 on cell surfaces and in plasma

Transfusion, 2020
BACKGROUNDAnti‐CD36s, developing after transfusion or during pregnancy, play an important role in immune‐mediated bleeding disorders among Asian populations. Currently, little is known about the clinical relevance of anti‐CD36. Here, we aimed to determine the frequency of CD36 deficiency in Thais by analyzing CD36 expression on cell surfaces and in ...
Roongaroon Phuangtham, Sentot Santoso, Chanvit Leelayuwat, Patcharee Komvilaisak, Haoqiang Ding, Amornrat V. Romphruk   +5 more
openaire   +3 more sources

Effects of aldehydes on CD36 expression

Free Radical Research, 2005
During the oil frying process lipid peroxidation compounds are formed. These products can modulate gene expression and alter cellular behaviour. The cellular uptake of oxidized LDL, a key step in the development of atherosclerosis, is mediated by the CD36 scavenger receptor, whose expression is down-regulated by alpha-tocopherol.To determine the ...
Marta Viana, Luis Villacorta, A. Indart, Jean-Marc Zingg, Isabel Sánchez-Vera, Adelina Munteanu, Arezki Azzi, Bartolomé Bonet   +7 more
openaire   +2 more sources

The Plasmodium falciparum–CD36 Interaction Is Modified by a Single Amino Acid Substitution in CD36

Blood, 1998
AbstractCD36 is an 88-kD glycoprotein involved in the cytoadherence ofPlasmodium falciparum–parasitized erythrocytes (PE) to endothelial cells. The molecular mechanisms involved in CD36-dependent cytoadherence were examined by expressing three CD36 homologues (human, murine, and rat) in COS-7 cells and observing their PE-binding characteristics over a ...
Ian Crandall, Lena Serghides, Eric Hull, Kevin C. Kain   +3 more
openaire   +3 more sources

CD36 expression and brain function: does CD36 deficiency impact learning ability?

Prostaglandins & Other Lipid Mediators, 2005
This article first presents an overview of published literature documenting the role of the scavenger receptor CD36 in activation of brain microglia with reference to brain pathologies such as Alzheimer's and malaria. Second, the possibility that CD36 may play a role in brain FA metabolism is discussed.
Mohammad Ajmal, John K. Robinson, Nada A. Abumrad, Kostas Pothakos   +3 more
openaire   +3 more sources

CD36 — the Achilles’ heel of Treg cells

Nature Immunology, 2020
Regulatory T (Treg) cells suppress antitumor immunity, but Treg cell inhibition has been hampered by a lack of specific targets. CD36 expression by tumor-infiltrating Treg cells may provide a way to specifically target Treg cells in tumors.
Brendan Horton, Stefani Spranger, Stefani Spranger   +2 more
openaire   +3 more sources

CD36 and malaria: friends or foes?

Trends in Parasitology, 2003
Past research efforts examining the adhesive characteristics of Plasmodium falciparum-infected erythrocytes have focused primarily on sequestration in the peripheral circulation. Recent work has begun to elucidate how these adhesive phenotypes can also modulate host response to infection and how host–parasite interactions might be exploited to improve ...
Samir N. Patel, Todd G. Smith, Lena Serghides, Kevin C. Kain   +3 more
openaire   +3 more sources

The Function of CD36 in Tumorigenesis

2022
During matrix detachment, tumor cells grow as multicellular clusters, and metabolism in this setting has been shown to recapitulate early stages of tumorigenesis. We previously found that detached cells activate AMPK to inhibit fatty acid synthesis and induce fatty acid oxidation, which raises the question of how clustered cells maintain the integrity ...
openaire   +1 more source

CD36 A critical anti angiogenic receptor

Frontiers in Bioscience, 2003
Thrombospondin-1 (TSP-1) is a potent inhibitor of angiogenesis in vivo and of microvascular endothelial cell responses to angiogenic factors in vitro. CD36 is the cellular receptor for TSP-1 on microvascular endothelium and is necessary for its anti-angiogenic activity.
Ronit Simantov, Roy L. Silverstein
openaire   +3 more sources

Genetics of Cd36 and the hypertension metabolic syndrome

Seminars in Nephrology, 2002
Although genetic mapping of quantitative trait loci (QTL) for complex traits related to hypertension is relatively straightforward, the identification of QTL at the molecular level has proven far more difficult. By combining techniques of gene mapping and gene expression profiling with studies in congenic and transgenic strains, a specific molecular ...
Michal Pravenec, Theodore W. Kurtz
openaire   +3 more sources