Results 141 to 150 of about 67,119 (304)

Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse

, 2013
During immunologic synapse (IS) formation, human CD38 redistributes to the contact area of T cell-antigen-presenting cell (APC) conjugates in an antigen- dependent manner.
Fuente, Hortensia de la, Muñoz, P., Malavasi, F., Sánchez-Madrid, Francisco, Pérez-Martínez, M., Zubiaur, Mercedes, Ariza-Veguillas, A., García-Pérez, A., Mittelbrunn, María, Sancho, Jaime   +9 more
core   +1 more source

Utility of combined CD39/CD73/CD38 expression for the detection of malignant T cells in Sézary syndrome

British Journal of Haematology, EarlyView.
Summary Sézary syndrome (SS) is an aggressive cutaneous T‐cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4+ T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS
Sara Marchisio, Yuliya Yakymiv, Liyun Lin, Erika Ortolan, Verdiana Pullano, Renata Ponti, Fenna J. de Bie, Alita J. van der Sluijs‐Gelling, Willem H. Zoutman, Valentina Pala, Ferenc A. Scheeren, Maarten H. Vermeer, Ada Funaro, Pietro Quaglino, Gabriele Roccuzzo   +14 more
wiley   +1 more source

Immunophenotypic Characterization of Patients with Chronic Lymphocytic Leukemia by Flow Cytometry; Association with Disease Prognosis

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of long-lived B lymphocytes within the peripheral blood, bone marrow, and secondary lymphoid organs.
Esmaeil Allahmoradi, Saeid Taghiloo, Ghasem Janbabaei, Ramin Shekarriz, Mohsen Tehrani, Hossein Asgarian-Omran   +5 more
doaj  

Cesni‐cel (ARI0002h) in ultra‐high‐risk multiple myeloma with plasma cell leukaemia or central nervous system involvement

British Journal of Haematology, EarlyView.
ARI0002h induced response in 15/17 patients with plasma cell leukaemia (PCL)/central nervous system (CNS)‐multiple myeloma (MM) (87% achieved ≥ very good partial response [VGPR]) with a median progression‐free survival (PFS)/overall survival (OS) of 10.5 and 15.9 months respectively.
Carlos Jimenez‐Mira, Natalia Tovar, Núria Martínez‐Cibrián, Verónica González‐Calle, Nil Albiol, Nieves López‐Muñoz, Aina Oliver‐Caldés, Azucena González, José Miguel Mateos, Marta Español‐Rego, Laura Rosiñol, Manel Juan, Paola Charry, José María Sanchez‐Pina, Sergio Navarro, Daniel Munárriz, Lucía López‐Corral, Valentín Ortiz‐Maldonado, Sara Varea, Eulalia Olesti, Julio Delgado, Álvaro Urbano‐Ispizua, Joaquín Martínez‐López, María Victoria Mateos, Luis Gerardo Rodríguez‐Lobato, Carlos Fernández de Larrea   +25 more
wiley   +1 more source

Characterizing CD38 expression in terminally differentiated B cells using variable lymphocyte receptor B tetramers

Frontiers in Immunology
IntroductionCD38 is an ectoenzyme receptor found on hematopoietic cells and its expression is used in the flow cytometric analysis of sub-populations of circulating B cells among peripheral blood mononuclear cells (PBMC) to aid in diagnosing patients ...
Arundhati G. Nair, Arundhati G. Nair, Matilde Leon-Ponte, Vy HD Kim, Gordon Sussman, Götz R.A. Ehrhardt, Eyal Grunebaum, Eyal Grunebaum, Eyal Grunebaum, Eyal Grunebaum   +9 more
doaj   +1 more source

The Role of Nicotinamide Adenine Dinucleotide in the Pathogenesis of Rheumatoid Arthritis: Potential Implications for Treatment

European Medical Journal, 2018
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease characterised by small joint swelling, deformity, and dysfunction. Its exact aetiology is unclear.
Weiqian Chen, Caihong Yi, Lin Jin
doaj  

ZDHHC9-mediated CD38 palmitoylation stabilizes CD38 expression and promotes pancreatic cancer growth

Communications Biology
The cluster of differentiation 38 (CD38) is a multifunctional transmembrane protein involved in numerous physiological and pathological processes including aging, neurodegenerative diseases, and tumorigenesis, hence is an attractive drug target. However, the mechanisms underlying the regulation of CD38 expression remain enigmatic. Herein, we report for
Hui Guo, Zhiqing Lin, Di Zhang, Qilong Qin, Zewen Li, Yuqing Yin, Jiangfan Chen, Wei Guo   +7 more
openaire   +3 more sources

Aislamiento y caracterización de anticuerpos de cadena pesada de dominio sencillo del tiburón Heterodontus francisci dirigidos contra CD38 murino

, 2011
Además de los anticuerpos convencionales, los tiburones desarrollaron anticuerpos compuestos por la cadena polipeptídica pesada denominados IgNAR, el fragmento variable de éstos se designa como vNAR y constituye los dominios de anticuerpo más pequeños ...
Karla Oyuky Juárez Moreno
core  

CD38 regulates LT-HSC quiescence.

(A) Frequencies of CD38- and CD38+ LT-HSCs in G0, G1, and SG2M phases of the cell cycle, n = 9. (B) BrdU incorporation assay. Frequency of BrdU+ cells in CD38- and CD38+ LT-HSC populations 14d after BrdU, n = 5.
Anupam Sinha (1974100), Andreas Dahl (2696749), Tatyana Grinenko (18078786), Malte von Bonin (400911), Juan Alberto Pérez-Valencia (18078780), Sema Elif Eski (10899813), Manja Wobus (326146), Liliia Ibneeva (18078774), Susanne Reinhardt (7824746), Martin Bornhäuser (219605), Sumeet Pal Singh (10899822), Alexander Gerbaulet (558872), Iryna Kovtun (18078777), Ben Wielockx (13181916), Jaime Sancho (329189), Marc Schmitz (357415), Rebekka Wehner (357414), Frances Lund (18078783), Triantafyllos Chavakis (5816888), Luise Rupp (15167618)   +19 more
core   +1 more source

The membrane-bound enzyme CD38 exists in two opposing orientations

, 2012
The transmembrane enzyme CD38, a multifunctional protein ubiquitously present in cells, is the main enzyme that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose (cADPR), an intracellular Ca(2+)-mobilizing messenger. CD38 is thought to be
Lam, MC, Zhao, Y, Lee, HC
core   +1 more source