Myeloid cell-mediated killing of B-ALL by CD38 and CD20 IgA antibody variants is enhanced by CD47/SIRPα interference. [PDF]
Lustig M +29 more
europepmc +1 more source
This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani +16 more
wiley +1 more source
The Host NADase CD38 Promotes JEV Replication by Targeting the NAD+/SIRT1 Axis. [PDF]
Yang Y +9 more
europepmc +1 more source
Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík +2 more
wiley +1 more source
Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons. [PDF]
Miyamoto T +6 more
europepmc +1 more source
Vitamin B3 (Nicotinamide) Supplementation in Primary and Scleroderma‐Related Raynaud Phenomenon
Objective The aim of this study was to explore if vitamin B3 (nicotinamide) supplementation is a safe and effective adjunctive therapy for patients with primary Raynaud phenomenon (RP) and scleroderma‐related RP. The effect of nicotinamide supplementation in human patients with RP has not been studied before.
Mogeshni Govender +8 more
wiley +1 more source
Targeting of CD28 and CD38 as a potential novel therapeutic strategy for peripheral T-cell lymphomas. [PDF]
Dupuy A +14 more
europepmc +1 more source
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng +5 more
wiley +1 more source
Monocyte-mediated metabolic rewiring via CD31-CD38 interactions promotes growth and drug-resistance in multiple myeloma. [PDF]
Raoof R +18 more
europepmc +1 more source

