Results 1 to 10 of about 2,983 (148)

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. [PDF]

Dev Biol, 2019
We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear.
Kelu JJ, Webb SE, Galione A, Miller AL.
europepmc   +7 more sources

ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1

FEBS Letters, 1994
Human BST‐1, a bone marrow stromal cell surface molecule, is a GPI‐anchored protein that facilitates the growth of pre‐B cells. The deduced amino acid sequences of human and mouse BST‐1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST‐1 might possess ADP ribosyl cyclase activity. Here, we report the
Y Hirata, Yoshiyuki Ohsugi, Shin Takasawa   +2 more
exaly   +4 more sources

Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons. [PDF]

J Neuroendocrinol
Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Miyamoto T, Matsushima A, Otubo A, Song C, Murata K, Oti T, Sakamoto H.   +6 more
europepmc   +2 more sources

The Na⁺/K⁺-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]

FASEB J
This study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc   +2 more sources

Synthesis of Bispecific Conjugates by ADP-Ribosyl Cyclases. [PDF]

Adv Sci (Weinh)
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Kim SH, Ansari AJ, Zhang L, Kao G, Hoang TO, Zhang Z, Singireddi S, Katz BB, Zhang Y.   +8 more
europepmc   +2 more sources

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury. [PDF]

CNS Neurosci Ther
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Zhu S, Zhong S, Lin X, Zhao C, Li Y.
europepmc   +2 more sources

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1. [PDF]

IUBMB Life
Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Dogan S, Walseth TF, Guvenc Tuna B, Uçar E, Kannan MS, Deshpande DA.   +5 more
europepmc   +2 more sources

Conceptual framework for SARS-CoV-2–related lymphopenia

Advanced Biomedical Research, 2022
The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh, Shirin Kouhpayeh, Yadollah Azizi, Hossein Khanahmad   +3 more
doaj   +1 more source

Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis

Frontiers in Medicine, 2022
Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue, Tsuyoshi Inoue, Yasuna Nakamura, Shinji Tanaka, Takahide Kohro, Lisa X. Li, Liping Huang, Junlan Yao, Suzuka Kawamura, Reiko Inoue, Hiroshi Nishi, Daichi Fukaya, Rie Uni, Sho Hasegawa, Reiko Inagi, Ryusuke Umene, Chia-Hsien Wu, Hong Ye, Amandeep Bajwa, Diane L. Rosin, Katsuhiko Ishihara, Masaomi Nangaku, Youichiro Wada, Mark D. Okusa   +23 more
doaj   +1 more source

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source