Results 31 to 40 of about 2,983 (148)

Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy.

, 2008
AIMS/HYPOTHESIS: ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5'diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral ...
Daisuke Chujo, Yoshiyu Takeda, Yamagishi, Masakazu, Junji Kobayashi, Naoko Ito, 46068, Sugihara, Masako, 90242544, Shintaku-Kubota, Miyuki, 70393238, ヤギ, クニマサ, Ito, Naoko, 477, 435, 30293343, Nohara, Atsushi, 60302577, 46066, 438, 46067, 46064, 46065, Yamaaki, Naoto, 46062, 46063, Higashida, Haruhiro, Masako Sugihara, Kobayashi, Junji, 36, Haruhiro Higashida, Ohtsuji, Michio, Naoto Yamaaki, 30093066, Chujo, Daisuke, Yukiko Kojima-Koba, Takeda, Yoshiyu, Masakazu Yamagishi, Kunimasa Yagi, Yagi, Kunimasa, 342, 265, Miyuki Shintaku-Kubota, Kojima-Koba, Yukiko, 50313648, Atsushi Nohara, Michio Ohtsuji   +45 more
core   +2 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source

Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase

, 2011
Cyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role.
DANIELA CALZIA, SILVIA RAVERA, GIOVANNI CANDIANO, M. Bruschi, G. Candiano., ANGELA BACHI, ANGELA CATTANEO, A. Bachi, A. Fabiano, MAURIZIO BRUSCHI, I. Panfoli, D. Calzia, ANDREA FABIANO, A. Morelli, A. Cattaneo, ALESSANDRO MORELLI, S. Ravera, ISABELLA PANFOLI   +17 more
core   +1 more source

Purification and cloning of brain isoform of ADP-ribosyl cyclase

, 2000
神経腫瘍細胞NG108-15細胞のADPリボシルシクラーゼは、ムスカリン受容体とカップルしていたが、脳のADPリボシルシクラーゼは、カップルする受容体が、数多くの試みの中からは検出できなかった。一方、心臓のADPリボシルシクラーゼは、イソプロテレノール、ノルアドレナリンやアンデオテンシンII刺激により、活性化された。私達の目的は受容体とカップルする膜型ADPリボシルシクラーゼの分子を決めることにあるので、さしあたり、ラット心室心筋を出発材料にすることにした。心筋を細分して低調液で、30分間浸け ...
69303, 東田, 陽博, 30093066
core   +1 more source

Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization

, 2008
In neurons, voltage-gated Ca2+ channels and nuclear Ca 2+ signaling play important roles, such as in the regulation of gene expression. However, the link between electrical activity and biochemical cascade activation involved in the generation of the ...
Bezin, Stéphanie, Baux, G, Cancela, JM, Lee, Hon Cheung, Fossier, P, Fossier, Philippe, Charpentier, G, Lee, HC, Baux, Gérard, Bezin, S, Charpentier, Gilles, Cancela, José-Manuel   +11 more
core   +1 more source

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-naïve chronic lymphocytic leukemia [PDF]

, 2017
ADP-ribosyl Cyclase 1; Disease Progression; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable[no abstract ...
Pizzolo, Giovanni, Gaidano, G., Giovanni Pizzolo, Elda Mimiola, SEMENZATO, GIANPIETRO CARLO, Purvis, N., Cesano, A., Cesano, Alessandra, ROMANELLI, Maria, Omar Perbellini, Scupoli, Maria T., Ambrosetti, Achille, Monica Facco, Gianpietro Semenzato, Santosh Putta, Maria T. Scupoli, Alessandra Cesano, Erika Falisi, Putta, S., Romanelli, Maria G, Norman Purvis, Mimiola, E., TRENTIN, LIVIO, Putta, Santosh, FACCO, MONICA, Semenzato, G., Carlo Visco, Livio Trentin, Visco, Carlo, Gaidano, Gianluca, Maria G. Romanelli, ROMANELLI, MARIA GIOVANNA, Perbellini, Omar, FALISI, ERIKA, Cavallini, Chiara, Davide Rossi, Mimiola, Elda, Falisi, E., Chiara Cavallini, Perbellini, O., Trentin, L., Purvis, Norman, Semenzato, Gianpietro, SCUPOLI, Maria, Gianluca Gaidano, Ornella Lovato, Achille Ambrosetti, ROSSI, DAVIDE, Facco, M., Lovato, Ornella, Rossi, D.   +50 more
core   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, Volume 24, Issue 10, October 2025.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

Immune Cell Proteins and Parkinson's Disease: A Mendelian Randomization Analysis of Causal Associations

Brain and Behavior, Volume 15, Issue 7, July 2025.
Mendelian randomization (MR) analysis was applied to elucidate the causal relationship between immune cell proteins and PD. Our study reveals a possible causal effect of immune cell proteins on the risk of PD and provides new ideas for the prevention and management of PD through immune cell proteins.
Haining Li, Jianhang He, Tingting Xuan, Shue Gu, Xiaoyan Niu, Yazhou Ren, Xiuping Zhan, Jiang Cheng   +7 more
wiley   +1 more source