Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases [PDF]
Advanced ScienceArmed with two distinct targeting moieties, artificially created bispecific agents can uniquely modulate various processes and events implicated in human health and diseases.
Sunny H. Kim +8 more
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Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes [PDF]
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
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Molecular characterization of a novel intracellular ADP-ribosyl cyclase. [PDF]
PLoS ONE, 2007 BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani +9 more
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A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases [PDF]
Nature CommunicationsCell-secreted exosomes have been emerging as an increasingly attractive form of nanomaterials for biomedical research. Various approaches have been established to genetically modify exosomes with proteins of interest for new and/or improved functions ...
Lei Zhang +11 more
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L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization. [PDF]
PLoS ONE, 2017 Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly +3 more
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The Na<sup>+</sup>/K<sup>+</sup>-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]
FASEB JThis study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc +2 more sources
Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons. [PDF]
J NeuroendocrinolAbstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Miyamoto T +6 more
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Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury. [PDF]
CNS Neurosci TherAdenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Zhu S, Zhong S, Lin X, Zhao C, Li Y.
europepmc +2 more sources
Сибирский научный медицинский журнал, 2021 The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova +4 more
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Quantitative and causal analysis for inflammatory genes and the risk of Parkinson’s disease
Frontiers in Immunology, 2023 BackgroundThe dysfunction of immune system and inflammation contribute to the Parkinson’s disease (PD) pathogenesis. Cytokines, oxidative stress, neurotoxin and metabolism associated enzymes participate in neuroinflammation in PD and the genes involved ...
Minhan Yi +12 more
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