Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes [PDF]
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
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The Na<sup>+</sup>/K<sup>+</sup>-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]
FASEB JThis study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc +3 more sources
Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases [PDF]
Advanced ScienceArmed with two distinct targeting moieties, artificially created bispecific agents can uniquely modulate various processes and events implicated in human health and diseases.
Sunny H. Kim +8 more
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L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization. [PDF]
PLoS ONE, 2017 Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly +3 more
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Molecular characterization of a novel intracellular ADP-ribosyl cyclase. [PDF]
PLoS ONE, 2007 BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani +9 more
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Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. [PDF]
Dev Biol, 2019 We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos.
Kelu JJ, Webb SE, Galione A, Miller AL.
europepmc +2 more sources
Antibacterial ADP-ribosyl cyclase toxins inhibit bacterial growth by rapidly depleting NAD(P). [PDF]
J Biol ChemIn metazoans, enzymes belonging to the bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose (cADPr) hydrolase family regulate diverse cellular processes by synthesizing and hydrolyzing the intracellular second messenger cADPr, derived from the electron ...
Colautti J, Kim Y, Whitney JC.
europepmc +2 more sources
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins. [PDF]
J Biol ChemBacterial polymorphic toxins are modular weapons that mediate intermicrobial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems.
Martinkus J +3 more
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Pharmacological ResearchLeukopenia is the most common side effect of chemotherapy and radiotherapy. It potentially deteriorates into a life-threatening complication in cancer patients.
Yuanzhi Liu +12 more
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Pathological Mechanisms in Sjögren's Disease Likely Involve the ADP-Ribosyl Cyclase Family Members: CD38 and CD157. [PDF]
Int J Mol SciPeripheral blood serves both as a source of effector immune cells that migrate to exocrine glands and as a reflection of the immunological changes occurring in patients with Sjögren’s disease (SjD).
Rosecka M +6 more
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