Results 21 to 30 of about 3,533 (177)

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins [PDF]

J Biol Chem
International audienceBacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems.
Martinkus, Julius, Jurėnas, Dukas, Terradot, Laurent, Cascales, Eric   +3 more
core   +2 more sources

Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase [PDF]

J Biol Chem, 2009
Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulatesmanyphysiological processes.Theproduction and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california ...
Jiang, H, Hao, Q, Kriksunov, IA, Zhang, B, Liu, Q, Lin, H, Potter, BVL, Graeff, R, Lee, HC, Oppenheimer, N   +9 more
core   +2 more sources

Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy. [PDF]

Exp Diabetes Res, 2008
AIMS/HYPOTHESIS: ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5'diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral ...
Daisuke Chujo, Yoshiyu Takeda, Yamagishi, Masakazu, Junji Kobayashi, Naoko Ito, 46068, Sugihara, Masako, 90242544, Shintaku-Kubota, Miyuki, 70393238, ヤギ, クニマサ, Ito, Naoko, 477, 435, 30293343, Nohara, Atsushi, 60302577, 46066, 438, 46067, 46064, 46065, Yamaaki, Naoto, 46062, 46063, Higashida, Haruhiro, Masako Sugihara, Kobayashi, Junji, 36, Haruhiro Higashida, Ohtsuji, Michio, Naoto Yamaaki, 30093066, Chujo, Daisuke, Yukiko Kojima-Koba, Takeda, Yoshiyu, Masakazu Yamagishi, Kunimasa Yagi, Yagi, Kunimasa, 342, 265, Miyuki Shintaku-Kubota, Kojima-Koba, Yukiko, 50313648, Atsushi Nohara, Michio Ohtsuji   +45 more
core   +2 more sources

Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure [PDF]

PeerJ, 2019
NAD glycohydrolase (EC 3.2.2.5) (NADase) sequences have been identified in 10 elapid and crotalid venom gland transcriptomes, eight of which are complete.
Ivan Koludarov, Steven D. Aird
doaj   +2 more sources

Conceptual framework for SARS-CoV-2–related lymphopenia

Advanced Biomedical Research, 2022
The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh, Shirin Kouhpayeh, Yadollah Azizi, Hossein Khanahmad   +3 more
doaj   +1 more source

Bone marrow stromal cell antigen-1 (CD157) regulated by sphingosine kinase 2 mediates kidney fibrosis

Frontiers in Medicine, 2022
Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue, Tsuyoshi Inoue, Yasuna Nakamura, Shinji Tanaka, Takahide Kohro, Lisa X. Li, Liping Huang, Junlan Yao, Suzuka Kawamura, Reiko Inoue, Hiroshi Nishi, Daichi Fukaya, Rie Uni, Sho Hasegawa, Reiko Inagi, Ryusuke Umene, Chia-Hsien Wu, Hong Ye, Amandeep Bajwa, Diane L. Rosin, Katsuhiko Ishihara, Masaomi Nangaku, Youichiro Wada, Mark D. Okusa   +23 more
doaj   +1 more source

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

iScience, 2022
Summary: SARM1 is an NAD(P) glycohydrolase and TLR adapter with an essential, prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD(P)ases, it catalyzes multiple reactions that need to be fully investigated.
Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G. Trapanotto, Christina Antoniou, Elisa Merlini, Michael P. Coleman, Giuseppe Orsomando   +8 more
doaj   +1 more source

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs [PDF]

Frontiers in Bioscience, 2014
The major ADP-ribosylating enzyme families are the focus of this special issue of Frontiers in Bioscience . However, there is room for another family of enzymes with the capacity to utilize nicotinamide adenine dinucleotide (NAD): the ADP-ribosyl cyclases (ARCs).
Enza, Ferrero, Nicola, Lo Buono, Alberto L, Horenstein, Ada, Funaro, Fabio, Malavasi   +4 more
openaire   +2 more sources

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Biomolecules, 2021
It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli, Faisal Hayat, Marie E. Migaud, Mathias Ziegler   +3 more
doaj   +1 more source