Results 21 to 30 of about 98,812 (142)

ADP-Ribosyl Cyclase and CD38 [PDF]

Biochemical Journal, 1997
The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Hon Cheung Lee, Richard M. Graeff, Timothy F. Walseth   +2 more
openaire   +4 more sources

Cd38/Adp-Ribosyl Cyclase [PDF]

The Journal of Cell Biology, 1999
The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD+ to cyclic ADP-ribose (cADPr). The latter gates Ca2+ release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library.
L, Sun, O A, Adebanjo, B S, Moonga, S, Corisdeo, H K, Anandatheerthavarada, G, Biswas, T, Arakawa, Y, Hakeda, A, Koval, B, Sodam, P J, Bevis, A J, Moser, F A, Lai, S, Epstein, B R, Troen, M, Kumegawa, M, Zaidi   +16 more
openaire   +2 more sources

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs [PDF]

Frontiers in Bioscience, 2014
The major ADP-ribosylating enzyme families are the focus of this special issue of Frontiers in Bioscience . However, there is room for another family of enzymes with the capacity to utilize nicotinamide adenine dinucleotide (NAD): the ADP-ribosyl cyclases (ARCs).
FERRERO, Enza, LO BUONO, NICOLA, HORENSTEIN, ALBERTO, FUNARO, Ada, MALAVASI, Fabio   +4 more
openaire   +3 more sources

Impaired NAD+ Metabolism in Neuronal Dysfunction in Critical Conditions

Общая реаниматология, 2008
The present views of the pathogenesis of neuronal dysfunction in critical conditions are analyzed, by taking into account of impairments of cellular NAD+ metabolism, the activity of NAD+-converting enzymes, including ADP-ribosyl cyclase/CD38, the ...
A. V Salmina, A. A. Fursov, S. V Mikhutkina, S. V. Shakhmayeva, N. S. Mantorova   +4 more
doaj   +1 more source

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Frontiers in Immunology, 2020
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the ...
Zayda L. Piedra-Quintero, Zachary Wilson, Zachary Wilson, Porfirio Nava, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +7 more
doaj   +1 more source

Changes in NAD/ADP-ribose metabolism in rectal cancer

Brazilian Journal of Medical and Biological Research, 2005
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe, L. Turker-Sener, A. Sener, G. Yetkin, D. Tiryaki, E. Bermek   +5 more
doaj   +1 more source

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Frontiers in Immunology, 2023
Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157.
Maria Gerasimenko, Haruhiro Higashida
doaj   +1 more source

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

PLoS ONE, 2021
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes.
Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sébastien Bolze, David E Moller   +4 more
doaj   +1 more source

ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1 [PDF]

, 1994
Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl ...
Ishikawa, Jun, Kaisho, Tsuneyasu, Ishihara, Katsuhiko, Naoki Kimura, Koh Sato, Katsuhiko Ishihara, Takasawa, Shin, Yoshiyuki Ohsugi, Kimura, Naoki, Shin Takasawa, Toshio Hirano, Jun Ishikawa, Ohsugi, Yoshiyuki, Hirata, Yuichi, Hirano, Toshio, Hiroshi Okamoto, Okamoto, Hiroshi, Tsuneyasu Kaisho, Sato, Koh, Yuichi Hirata   +19 more
core   +1 more source

The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.: CD38-independent ADP-ribosyl cyclase from brain synaptosomes [PDF]

, 2006
International audiencecADPR (cADP-ribose), a metabolite of NAD+, is known to modulate intracellular calcium levels and to be involved in calcium-dependent processes, including synaptic transmission, plasticity and neuronal excitability.
Moutin, Marie-Jo, Ronjat, Michel, Pochon, Nathalie, Muller-Steffner, Hélène, Baratier, Julie, Villaz, Michel, Ceni, Claire, Schuber, Francis, de Waard, Michel   +8 more
core   +1 more source