Results 21 to 30 of about 10,542 (222)
Structure, 2004 ADP-ribosyl cyclase catalyzes the elimination of nicotinamide from NAD and cyclization to cADPR, a known second messenger in cellular calcium signaling pathways. We have determined to 2.0 Å resolution the structure of Aplysia cyclase with ribose-5-phosphate bound covalently at C3′ and with the base exchange substrate (BES), pyridylcarbinol, bound to ...
Love, Michael L +7 more
openaire +5 more sources
Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase [PDF]
, 2015 Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and
Cabezas, Alicia +8 more
core +13 more sources
Сибирский научный медицинский журнал, 2021 The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova +4 more
doaj +1 more source
ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST‐1
FEBS Letters, 1994 Y. Hirata +9 more
semanticscholar +3 more sources
ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation. [PDF]
Circulation Research, 2000 Abstract —We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs) has enzymatic properties that differ from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells. ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by gangliosides
Frederico G. S. de Toledo +4 more
semanticscholar +3 more sources
Cd38/Adp-Ribosyl Cyclase [PDF]
The Journal of Cell Biology, 1999 The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD+ to cyclic ADP-ribose (cADPr). The latter gates Ca2+ release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library.
Li Sun +16 more
openaire +1 more source
Quantitative and causal analysis for inflammatory genes and the risk of Parkinson’s disease
Frontiers in Immunology, 2023 BackgroundThe dysfunction of immune system and inflammation contribute to the Parkinson’s disease (PD) pathogenesis. Cytokines, oxidative stress, neurotoxin and metabolism associated enzymes participate in neuroinflammation in PD and the genes involved ...
Minhan Yi +12 more
doaj +1 more source
Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure [PDF]
PeerJ, 2019 NAD glycohydrolase (EC 3.2.2.5) (NADase) sequences have been identified in 10 elapid and crotalid venom gland transcriptomes, eight of which are complete.
Ivan Koludarov, Steven D. Aird
doaj +2 more sources
Conceptual framework for SARS-CoV-2–related lymphopenia
Advanced Biomedical Research, 2022 The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh +3 more
doaj +1 more source
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
doaj +1 more source