Results 31 to 40 of about 2,704 (153)

ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]

Messenger, 2016
ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis.
Ramakrishnan, L, Uhlinger, K, Dale, L, Hamdoun, A, Patel, S   +4 more
openaire   +4 more sources

CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1

Scientific Reports, 2021
CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardia, Massimo Massaia, Enza Ferrero, Erika Ortolan, Ada Funaro   +9 more
doaj   +1 more source

A Single Residue in a Novel ADP-ribosyl Cyclase Controls Production of the Calcium-mobilizing Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate

Journal of Biological Chemistry, 2010
Sandip Patel, Christophe Bosc, Marie-Jo Moutin   +2 more
exaly   +2 more sources

Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform. [PDF]

Biochem J, 2004
The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Bacher I, Zidar A, Kratzel M, Hohenegger M.   +3 more
europepmc   +5 more sources

Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment

Pharmacological Research
Leukopenia is the most common side effect of chemotherapy and radiotherapy. It potentially deteriorates into a life-threatening complication in cancer patients.
Yuanzhi Liu, Linwei Zhang, Long Wang, Xiaoqin Tang, Shengli Wan, Qianqian Huang, Mei Ran, Hongping Shen, Yan Yang, Sawitree Chiampanichayakul, Singkome Tima, Songyot Anuchapreeda, Jianming Wu   +12 more
doaj   +1 more source

The Expression of CD38 ADP-ribosyl Cyclase Ectoenzyme in Immune Cells of Cardiac Surgical Patients

Acta Medica, 2008
Background: This study was aimed at following the changes in the expression of CD38 ADP-ribosyl cyclase ectoenzyme on peripheral blood immune cells of patients undergoing cardiac surgical operations.
Martina Koláčková, Manuela Trojáčková Kudlová, Vladimír Lonský, Jiří Manďák, Pavel Kuneš, Karolína Jankovičová, Dana Vlášková, Ctirad Andrýs, Jan Krejsek   +8 more
doaj   +1 more source

One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population

Diseases, 2020
The transient receptor potential melastatin 2 (TRPM2) is a non-specific cation channel, resulting in Ca2+ influx at warm temperatures from 34 °C to 47 °C, thus including the body temperature range in mammals.
Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida   +6 more
doaj   +1 more source

Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. [PDF]

PLoS ONE, 2013
Preceding studies on the mode of action of non-genotoxic hepatocarcinogens (NGCs) have concentrated on alterations induced in hepatocytes (HCs). A potential role of non-parenchymal liver cells (NPCs) in NGC-driven hepatocarcinogenesis has been largely ...
Philip Klepeisz, Sandra Sagmeister, Verena Haudek-Prinz, Melanie Pichlbauer, Bettina Grasl-Kraupp, Christopher Gerner   +5 more
doaj   +1 more source

ADP‐ribosyl cyclase coupled with receptors via G proteins [PDF]

FEBS Letters, 1997
Crude cell membranes in mammalian cells contain ADP‐ribosyl cyclase, which converts NAD+ to cyclic ADP‐ribose. Acetylcholine either increases or inhibits this activity in NG108‐15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor subtype‐specific manner.
openaire   +2 more sources

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases [PDF]

Science Advances, 2020
A new approach is developed for generating site-specific antibody-drug conjugates for targeted therapy.
Zhefu Dai, Xiao-Nan Zhang, Fariborz Nasertorabi, Qinqin Cheng, Jiawei Li, Benjamin B. Katz, Goar Smbatyan, Hua Pei, Stan G. Louie, Heinz-Josef Lenz, Raymond C. Stevens, Yong Zhang   +11 more
openaire   +2 more sources