Results 31 to 40 of about 3,533 (177)

Impaired NAD+ Metabolism in Neuronal Dysfunction in Critical Conditions

Общая реаниматология, 2008
The present views of the pathogenesis of neuronal dysfunction in critical conditions are analyzed, by taking into account of impairments of cellular NAD+ metabolism, the activity of NAD+-converting enzymes, including ADP-ribosyl cyclase/CD38, the ...
A. V Salmina, A. A. Fursov, S. V Mikhutkina, S. V. Shakhmayeva, N. S. Mantorova   +4 more
doaj   +1 more source

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Frontiers in Immunology, 2020
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the ...
Zayda L. Piedra-Quintero, Zachary Wilson, Zachary Wilson, Porfirio Nava, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +7 more
doaj   +1 more source

Changes in NAD/ADP-ribose metabolism in rectal cancer

Brazilian Journal of Medical and Biological Research, 2005
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe, L. Turker-Sener, A. Sener, G. Yetkin, D. Tiryaki, E. Bermek   +5 more
doaj   +1 more source

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Frontiers in Immunology, 2023
Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157.
Maria Gerasimenko, Haruhiro Higashida
doaj   +1 more source

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

PLoS ONE, 2021
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes.
Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sébastien Bolze, David E Moller   +4 more
doaj   +1 more source

Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network

Scientific Reports, 2021
Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi, Albert Anatolyevich Rizvanov, Bahareh Dabirmanesh, Ilnur Ildusovich Salafutdinov, Mohammad Sayyah, Amir Shojaei, Javad Zahiri, Javad Mirnajafi-Zadeh, Babak Khorsand, Khosro Khajeh, Yaghoub Fathollahi   +10 more
doaj   +1 more source

Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality

Frontiers in Genetics, 2022
Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu, Yan Wu, Yanyan Sun, Hao Zhang, Hongwei Xiao, Ailuan Pan, Jie Shen, Yuejin Pu, Zhenhua Liang, Jinping Du, Jinsong Pi   +10 more
doaj   +1 more source

The roles of oxytocin and CD38 in social or parental behaviors

Frontiers in Neuroscience, 2013
The nine amino acid peptide oxytocin (OXT) has been directly associated with different types of behavioral reactions. The formation and maintenance of social relationships in youth and middle age are important components of human mental health. A deficit
Olga eLopatina, Alyona eInzhutova, Alla B. Salmina, Haruhiro eHigashida   +3 more
doaj   +1 more source

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases [PDF]

Science Advances, 2020
A new approach is developed for generating site-specific antibody-drug conjugates for targeted therapy.
Zhefu Dai, Xiao-Nan Zhang, Fariborz Nasertorabi, Qinqin Cheng, Jiawei Li, Benjamin B. Katz, Goar Smbatyan, Hua Pei, Stan G. Louie, Heinz-Josef Lenz, Raymond C. Stevens, Yong Zhang   +11 more
openaire   +2 more sources

CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1

Scientific Reports, 2021
CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardia, Massimo Massaia, Enza Ferrero, Erika Ortolan, Ada Funaro   +9 more
doaj   +1 more source