Results 31 to 40 of about 10,542 (222)

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

iScience, 2022
Summary: SARM1 is an NAD(P) glycohydrolase and TLR adapter with an essential, prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD(P)ases, it catalyzes multiple reactions that need to be fully investigated.
Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G. Trapanotto, Christina Antoniou, Elisa Merlini, Michael P. Coleman, Giuseppe Orsomando   +8 more
doaj   +1 more source

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway [PDF]

, 2014
published_or_final_versio
Graeff, RM, Wei, W, Yue, J
core   +1 more source

Prevention of Postischemic Neurological Deficit by Modulating the Cerebral Cell Expression of ADP-Ribosyl Cyclase (Experimental Study)

Общая реаниматология, 2007
Objective: to study the mechanism that is responsible for impaired neuronal cell electroexcitability and viability, which is associated with modification of ADP-ribosyl cyclase in cerebral ischemic lesion, as well as the possibilities of pathogenet ...
A. A. Fursov, A. B. Salmina, S. V. Mikhutkina, L. D. Zykova, N. A., Malinovskaya, A. V. Morgun, D. I. Laletin, M. A. Fursov, G. V. Yudin, N. A. Shnayder, S. V. Shakhmaeva   +10 more
doaj   +1 more source

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Biomolecules, 2021
It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli, Faisal Hayat, Marie E. Migaud, Mathias Ziegler   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs [PDF]

, 2018
Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts.
Borbone, Nicola, Catalanotti, Bruno, Costantino, Valeria, D'Errico, Stefano, Mayol, Luciano, Oliviero, Giorgia, Pannaccione, Anna, Petrozziello, Tiziana, Piccialli, Gennaro, Piccialli, Ilaria, Secondo, Agnese   +10 more
core   +2 more sources

Impaired NAD+ Metabolism in Neuronal Dysfunction in Critical Conditions

Общая реаниматология, 2008
The present views of the pathogenesis of neuronal dysfunction in critical conditions are analyzed, by taking into account of impairments of cellular NAD+ metabolism, the activity of NAD+-converting enzymes, including ADP-ribosyl cyclase/CD38, the ...
A. V Salmina, A. A. Fursov, S. V Mikhutkina, S. V. Shakhmayeva, N. S. Mantorova   +4 more
doaj   +1 more source

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Frontiers in Immunology, 2020
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed either on the cell surface, where it may face the extracellular milieu or the ...
Zayda L. Piedra-Quintero, Zachary Wilson, Zachary Wilson, Porfirio Nava, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +7 more
doaj   +1 more source

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome [PDF]

, 2014
Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic ...
Barbosa, Maria Thereza, Capellini, Verena, Chini, Eduardo N., Escande, Carlos, Gomes, Ana P., Nin, Veronica, O’Neil, Luke, Price, Nathan L., Sinclair, David A., White, Thomas A.   +9 more
core   +1 more source

Changes in NAD/ADP-ribose metabolism in rectal cancer

Brazilian Journal of Medical and Biological Research, 2005
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe, L. Turker-Sener, A. Sener, G. Yetkin, D. Tiryaki, E. Bermek   +5 more
doaj   +1 more source