Results 31 to 40 of about 98,812 (142)

Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network

Scientific Reports, 2021
Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi, Albert Anatolyevich Rizvanov, Bahareh Dabirmanesh, Ilnur Ildusovich Salafutdinov, Mohammad Sayyah, Amir Shojaei, Javad Zahiri, Javad Mirnajafi-Zadeh, Babak Khorsand, Khosro Khajeh, Yaghoub Fathollahi   +10 more
doaj   +1 more source

The roles of oxytocin and CD38 in social or parental behaviors

Frontiers in Neuroscience, 2013
The nine amino acid peptide oxytocin (OXT) has been directly associated with different types of behavioral reactions. The formation and maintenance of social relationships in youth and middle age are important components of human mental health. A deficit
Olga eLopatina, Alyona eInzhutova, Alla B. Salmina, Haruhiro eHigashida   +3 more
doaj   +1 more source

Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality

Frontiers in Genetics, 2022
Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu, Yan Wu, Yanyan Sun, Hao Zhang, Hongwei Xiao, Ailuan Pan, Jie Shen, Yuejin Pu, Zhenhua Liang, Jinping Du, Jinsong Pi   +10 more
doaj   +1 more source

Molecular Characterization of ADP-ribosyl Cyclase Coupled with Receptors [PDF]

, 2003
細胞内のCaをセカンドメッセンジャーとするCaシグナリングは、数多くの受容体の下流に存在する重要な信号伝達機構の一つである。最近、リアノジン感受性の細胞内Caプールを開く細胞内リガンドはサイクリックADPリボース(cADPR)であると考えられるようになってきた。この数年、我々はcADPRがIP3のようなセカンドメッセンジャーであるとするこの仮説を検証してきた。そしてNADからcADPRを産生する膜酵素が受容体によりコントロールされていることをムスカリン受容体を大量発現するNG108-15細胞(J.B.C.
69303, 東田, 陽博, 30093066
core   +1 more source

CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1

Scientific Reports, 2021
CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardia, Massimo Massaia, Enza Ferrero, Erika Ortolan, Ada Funaro   +9 more
doaj   +1 more source

Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment

Pharmacological Research
Leukopenia is the most common side effect of chemotherapy and radiotherapy. It potentially deteriorates into a life-threatening complication in cancer patients.
Yuanzhi Liu, Linwei Zhang, Long Wang, Xiaoqin Tang, Shengli Wan, Qianqian Huang, Mei Ran, Hongping Shen, Yan Yang, Sawitree Chiampanichayakul, Singkome Tima, Songyot Anuchapreeda, Jianming Wu   +12 more
doaj   +1 more source

The Expression of CD38 ADP-ribosyl Cyclase Ectoenzyme in Immune Cells of Cardiac Surgical Patients

Acta Medica, 2008
Background: This study was aimed at following the changes in the expression of CD38 ADP-ribosyl cyclase ectoenzyme on peripheral blood immune cells of patients undergoing cardiac surgical operations.
Martina Koláčková, Manuela Trojáčková Kudlová, Vladimír Lonský, Jiří Manďák, Pavel Kuneš, Karolína Jankovičová, Dana Vlášková, Ctirad Andrýs, Jan Krejsek   +8 more
doaj   +1 more source

Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. [PDF]

PLoS ONE, 2013
Preceding studies on the mode of action of non-genotoxic hepatocarcinogens (NGCs) have concentrated on alterations induced in hepatocytes (HCs). A potential role of non-parenchymal liver cells (NPCs) in NGC-driven hepatocarcinogenesis has been largely ...
Philip Klepeisz, Sandra Sagmeister, Verena Haudek-Prinz, Melanie Pichlbauer, Bettina Grasl-Kraupp, Christopher Gerner   +5 more
doaj   +1 more source

Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]

, 1992
3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland, Jürgen Ervens, Roland Seifert, Ervens, J.   +3 more
core   +1 more source

One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population

Diseases, 2020
The transient receptor potential melastatin 2 (TRPM2) is a non-specific cation channel, resulting in Ca2+ influx at warm temperatures from 34 °C to 47 °C, thus including the body temperature range in mammals.
Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida   +6 more
doaj   +1 more source