Results 11 to 20 of about 10,542 (222)

Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons. [PDF]

J Neuroendocrinol
Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Miyamoto T, Matsushima A, Otubo A, Song C, Murata K, Oti T, Sakamoto H.   +6 more
europepmc   +2 more sources

Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. [PDF]

J Biol Chem, 2009
Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca2+ messenger molecule responsible for regulating a wide range of cellular ...
Graeff R, Liu Q, Kriksunov IA, Kotaka M, Oppenheimer N, Hao Q, Lee HC.   +6 more
europepmc   +2 more sources

Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. [PDF]

J Biol Chem, 2009
Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulates many physiological processes. The production and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia ...
Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, Hao Q.   +9 more
europepmc   +2 more sources

A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases [PDF]

Nature Communications
Cell-secreted exosomes have been emerging as an increasingly attractive form of nanomaterials for biomedical research. Various approaches have been established to genetically modify exosomes with proteins of interest for new and/or improved functions ...
Lei Zhang, Srinivasarao Singireddi, Arshad J. Ansari, Guoyun Kao, Sunny H. Kim, Zeyu Zhang, Kaiyu Shen, Thuc Oanh Hoang, Xinping Duan, Qinqin Cheng, Tautis Skorka, Yong Zhang   +11 more
doaj   +2 more sources

Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. [PDF]

J Med Chem, 2014
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation.
Swarbrick JM, Graeff R, Zhang H, Thomas MP, Hao Q, Potter BV.   +5 more
europepmc   +2 more sources

CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain. [PDF]

Biochem J, 2003
CD38 is a transmembrane glycoprotein that is expressed in many tissues throughout the body. In addition to its major NAD+-glycohydrolase activity, CD38 is also able to synthesize cyclic ADP-ribose, an endogenous calcium-regulating molecule, from NAD+.
Ceni C, Pochon N, Brun V, Muller-Steffner H, Andrieux A, Grunwald D, Schuber F, De Waard M, Lund F, Villaz M, Moutin MJ.   +10 more
europepmc   +5 more sources

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1. [PDF]

IUBMB Life
Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Dogan S, Walseth TF, Guvenc Tuna B, Uçar E, Kannan MS, Deshpande DA.   +5 more
europepmc   +2 more sources

Characterization of the Active Site of ADP-ribosyl Cyclase* [PDF]

Journal of Biological Chemistry, 1999
ADP-ribosyl cyclase synthesizes two Ca2+ messengers by cyclizing NAD to produce cyclic ADP-ribose and exchanging nicotinic acid with the nicotinamide group of NADP to produce nicotinic acid adenine dinucleotide phosphate.
C. Munshi, D. Thiel, I. Mathews, R. Aarhus, T. Walseth, Hon-cheung Lee   +5 more
semanticscholar   +5 more sources

ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]

Messenger, 2016
ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP.
Dale, L, Hamdoun, A, Patel, S, Ramakrishnan, L, Uhlinger, K   +4 more
core   +8 more sources

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice.

Neuropharmacology, 2010
Locally released oxytocin (OT) activates OT receptors (2.1:OXY:1:OT:) in neighboring neurons in the hypothalamus and their terminals in the posterior pituitary, resulting in further OT release, best known in autoregulation occurring during labor or milk ...
O. Lopatina, Hong-Xiang Liu, S. Amina, M. Hashii, H. Higashida   +4 more
semanticscholar   +3 more sources