Results 11 to 20 of about 98,812 (142)

Molecular characterization of a novel intracellular ADP-ribosyl cyclase. [PDF]

PLoS ONE, 2007
BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani, Michael J Boulware, Timothy J Geach, Andrew C R Martin, Gary W Moy, Yi-Hsien Su, Victor D Vacquier, Jonathan S Marchant, Leslie Dale, Sandip Patel   +9 more
doaj   +5 more sources

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science
Armed with two distinct targeting moieties, artificially created bispecific agents can uniquely modulate various processes and events implicated in human health and diseases.
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
doaj   +5 more sources

Characterization of the active site of ADP-ribosyl cyclase [PDF]

Journal of Biological Chemistry, 1999
ADP-ribosyl cyclase synthesizes two Ca2+ messengers by cyclizing NAD to produce cyclic ADP-ribose and exchanging nicotinic acid with the nicotinamide group of NADP to produce nicotinic acid adenine dinucleotide phosphate.
Munshi, C, Mathews, II, Walseth, TF, Thiel, DJ, Aarhus, R, Lee, HC   +5 more
core   +5 more sources

ADP-ribosyl cyclase: Crystal structures reveal a covalent intermediate [PDF]

Structure, 2004
ADP-ribosyl cyclase catalyzes the elimination of nicotinamide from NAD and cyclization to cADPR, a known second messenger in cellular calcium signaling pathways.
Graeff, Richard, Hao, Q, Munshi, Cyrus, Kriksunov, IA, Love, ML, Lee, Hon Cheung, Thiel, DJ, Doletha M.E Szebenyi, Graeff, R, Kriksunov, Irina A, Lee, HC, Daniel J Thiel, Munshi, C, Irina A Kriksunov, Richard Graeff, Hon Cheung Lee, Love, Michael L, Thiel, Daniel J, Hao, Quan, Quan Hao, Szebenyi, DME, Szebenyi, Doletha M.E, Cyrus Munshi, Michael L Love   +23 more
core   +7 more sources

ADP-ribosyl cyclase coupled with receptors via G proteins [PDF]

FEBS Letters, 1997
Crude cell membranes in mammalian cells contain ADP-ribosyl cyclase, which converts NAD+ to cyclic ADP-ribose. Acetylcholine either increases or inhibits this activity in NG108-15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor ...
Haruhiro Higashida, Higashida, Haruhiro
core   +4 more sources

ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]

Messenger, 2016
ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP.
Uhlinger, K, Ramakrishnan, L, Hamdoun, A, Patel, S, Dale, L   +4 more
core   +7 more sources

Crystallization of ADP-ribosyl cyclase from Aplysia californica

Proteins: Structure, Function, and Genetics, 1996
ADP-ribosyl cyclase synthesizes the secondary messenger cyclic ADP-ribose from NAD+. Diffraction quality crystals of the enzyme from ovotestes of Aplysia californica have been obtained. Crystallographic analysis of this enzyme will yield insight into the
Prasad, GS, Stout, CD, Levitt, DG, Lee, HC   +3 more
core   +4 more sources

Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38 [PDF]

Journal of Biological Chemistry, 2009
Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca2+ messenger molecule responsible for regulating a wide range of cellular ...
Hao, Q, Kriksunov, IA, Liu, Q, Kotaka, M, Graeff, R, Lee, HC, Oppenheimer, N   +6 more
core   +5 more sources

A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases

Nature Communications
Cell-secreted exosomes have been emerging as an increasingly attractive form of nanomaterials for biomedical research. Various approaches have been established to genetically modify exosomes with proteins of interest for new and/or improved functions ...
Lei Zhang, Srinivasarao Singireddi, Arshad J. Ansari, Guoyun Kao, Sunny H. Kim, Zeyu Zhang, Kaiyu Shen, Thuc Oanh Hoang, Xinping Duan, Qinqin Cheng, Tautis Skorka, Yong Zhang   +11 more
doaj   +3 more sources

Structural studies of intermediates along the cyclization pathway of aplysia ADP-ribosyl cyclase

Journal of Molecular Biology, 2012
Cyclic ADP-ribose (cADPR) is a calcium messenger that can mobilize intracellular Ca 2+ stores and activate Ca 2+ influx to regulate a wide range of physiological processes.
Graeff, Richard, Hao, Q, Chen, Z, Zhang, LH, Lee, Hon Cheung, Kotaka, M, Graeff, R, Lee, HC, Kotaka, Masayo, Li He Zhang, Richard Graeff, Hon Cheung Lee, Masayo Kotaka, Hao, Quan, Zhe Chen, Quan Hao, Chen, Zhe, Zhang, Li He   +17 more
core   +5 more sources