Results 11 to 20 of about 3,533 (177)
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38 [PDF]
Journal of Biological Chemistry, 2009 Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca(2+) messenger molecule responsible for regulating a wide range of cellular functions.
Liu, Q +6 more
core +6 more sources
The Na + /K + ‐ATPase β1 Subunit is a Kidney ADP‐Ribosyl Cyclase [PDF]
The FASEB JournalABSTRACT ADP‐ribosyl cyclase (ARC) produces a Ca 2+ ‐mobilizing second messenger, cyclic ADP‐ribose (cADPR), from NAD. In this study, we purified an ARC from rat kidney, which was identified as the β1 subunit of Na, K‐ATPase (Atp1b1).
Tae‐Sik Nam +2 more
wiley +5 more sources
Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol‐facing catalytic domain in primate oxytocin neurons [PDF]
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Tatsuki Miyamoto +6 more
wiley +2 more sources
ADP‐ribosyl cyclase coupled with receptors via G proteins [PDF]
FEBS Letters, 1997 Crude cell membranes in mammalian cells contain ADP‐ribosyl cyclase, which converts NAD+ to cyclic ADP‐ribose. Acetylcholine either increases or inhibits this activity in NG108‐15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor subtype‐specific manner.
Haruhiro Higashida, Higashida, Haruhiro
openaire +3 more sources
ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]
Messenger, 2016 ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis.
Ramakrishnan, L +4 more
openaire +6 more sources
Общая реаниматология, 2007 Objective: to study the mechanism that is responsible for impaired neuronal cell electroexcitability and viability, which is associated with modification of ADP-ribosyl cyclase in cerebral ischemic lesion, as well as the possibilities of pathogenet ...
A. A. Fursov +10 more
doaj +3 more sources
L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization. [PDF]
PLoS ONE, 2017 Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly +3 more
doaj +2 more sources
ADP-Ribosyl Cyclase and CD38 [PDF]
Biochemical Journal, 1997 The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Hon Cheung Lee +2 more
europepmc +5 more sources
Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury [PDF]
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu +4 more
wiley +2 more sources
CD38/cADPR‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1 [PDF]
IUBMB Life, Volume 76, Issue 12, Page 1223-1233, December 2024.Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Soner Dogan +5 more
wiley +2 more sources