Results 41 to 50 of about 98,812 (142)

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases [PDF]

Science Advances, 2020
A new approach is developed for generating site-specific antibody-drug conjugates for targeted therapy.
Zhefu Dai, Xiao-Nan Zhang, Fariborz Nasertorabi, Qinqin Cheng, Jiawei Li, Benjamin B. Katz, Goar Smbatyan, Hua Pei, Stan G. Louie, Heinz-Josef Lenz, Raymond C. Stevens, Yong Zhang   +11 more
openaire   +2 more sources

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease

Frontiers in Behavioral Neuroscience, 2014
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in
Olga eLopatina, Toru eYoshihara, Tomoko eNishimura, Jing eZhong, Shirin eAkther, Azam AKM Fakhrul, Mingkun eLiang, Chiharu eHigashida, Kohei eSumi, Kazumi eFuruhara, Yuki eInahata, Jianjun eHuang, Keita eKoizumi, Shigeru eYokoyama, Takahiro eTsuji, Yu ePetugina, Andrei eSumarukov, Alla B. Salmina, Koji eHashida, Yasuko eKitao, Osamu eHori, Masahide eAsano, Yoji eKitamura, Takashi eKozaka, Kazuhiro eShiba, Fangfang eZhong, Min-Jue eXie, Makoto eSato, Katsuhiko eIshihara, Haruhiro eHigashida   +29 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Marco Borso, Jan Ruprecht, Christopher Vorreiter, Sabrina Rast, Lin Zhang, Matthias Schiedel, Wolfgang Sippl, Axel Imhof, Henning J. Jessen, Oliver Einsle, Mike Schutkowski, Manfred Jung   +16 more
wiley   +2 more sources

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin [PDF]

, 2010
Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
core  

Effect of Intermittent Fasting on Weight Loss in Overweight and Obese Adults: A Systematic Review of Clinical Trials

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This systematic review screened 2307 records identified through PubMed, Cochrane Library, Google Scholar, and ScienceDirect, following PRISMA 2020 criteria. The search yielded 26 eligible clinical trials (24 RCTs, 2 non‐randomized studies) on intermittent fasting (TRE 16:8/20:4/14:10/18:6, alternate‐day fasting, and 5:2 fasting) for weight loss in ...
Hafiz Muhammad Irfan Manzoor, Muhammad Tauseef Sultan, Aneela Hameed, Ahmad Mujtaba Noman, Mahnoor Khalid, Maheen Kazmi, Aiman Sohail, Mohamed Fawzy Ramadan, Eliasse Zongo, Muhammad Abdul Rahim, Fahad Al‐Asmari   +10 more
wiley   +1 more source

Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase [PDF]

Biochemical Journal, 1997
The present investigation identifies bovine liver mitochondrial NADase (NAD+ glycohydrolase) as a member of the class of bifunctional ADP-ribosyl cyclases/cyclic ADP-ribose hydrolases, known to be potential second messenger enzymes. These enzymes catalyse the synthesis and degradation of cyclic ADP-ribose, a potent intracellular calcium-mobilizing ...
M, Ziegler, D, Jorcke, M, Schweiger
openaire   +2 more sources

Sex, Receptors and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

Frontiers in Neuroscience, 2013
As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (IN OT) is demonstrating a growing potential as a therapeutic agent in psychiatry.
Kai S Macdonald
doaj   +1 more source