Results 41 to 50 of about 10,542 (222)

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Frontiers in Immunology, 2023
Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157.
Maria Gerasimenko, Haruhiro Higashida
doaj   +1 more source

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

PLoS ONE, 2021
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes.
Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sébastien Bolze, David E Moller   +4 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase. [PDF]

Biochemical Journal, 1997
The present investigation identifies bovine liver mitochondrial NADase (NAD+ glycohydrolase) as a member of the class of bifunctional ADP-ribosyl cyclases/cyclic ADP-ribose hydrolases, known to be potential second messenger enzymes. These enzymes catalyse the synthesis and degradation of cyclic ADP-ribose, a potent intracellular calcium-mobilizing ...
Mathias Ziegler, D. Jorcke, Manfred Schweiger   +2 more
semanticscholar   +3 more sources

Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases [PDF]

Science Advances, 2020
A new approach is developed for generating site-specific antibody-drug conjugates for targeted therapy.
Zhefu Dai, Xiao-Nan Zhang, Fariborz Nasertorabi, Qinqin Cheng, Jiawei Li, Benjamin B. Katz, Goar Smbatyan, Hua Pei, Stan G. Louie, Heinz-Josef Lenz, Raymond C. Stevens, Yong Zhang   +11 more
openaire   +2 more sources

Proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy: potential targets in calcium regulatory network

Scientific Reports, 2021
Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi, Albert Anatolyevich Rizvanov, Bahareh Dabirmanesh, Ilnur Ildusovich Salafutdinov, Mohammad Sayyah, Amir Shojaei, Javad Zahiri, Javad Mirnajafi-Zadeh, Babak Khorsand, Khosro Khajeh, Yaghoub Fathollahi   +10 more
doaj   +1 more source

Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS [PDF]

, 2015
ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP ...
Colanzi, Antonino, Corda, Daniela, Lalioti, Vasiliky S.   +2 more
core   +1 more source

Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality

Frontiers in Genetics, 2022
Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu, Yan Wu, Yanyan Sun, Hao Zhang, Hongwei Xiao, Ailuan Pan, Jie Shen, Yuejin Pu, Zhenhua Liang, Jinping Du, Jinsong Pi   +10 more
doaj   +1 more source

ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.

Am J Physiol Renal Physiol, 2008
Thai TL, Arendshorst WJ.
europepmc   +2 more sources

The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]

, 2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika, Nikiforov, Andrey, Ziegler, Mathias   +2 more
core   +2 more sources