Results 51 to 60 of about 98,812 (142)

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source

ADP Ribosyl Cyclase, Activity In Rat Parotid, Acinar Cells

, 1998
ADP ribosyl cyclase, cyclic ADP-ribose, intracellular calcium, parotid acinar ...
Dissing, S., Looms, D.K., Nauntofte, Birgitte   +2 more
core   +1 more source

L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization.

PLoS ONE, 2017
Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly, Dina M El-Sharawy, Marwa S El Refaye, Sahar S Abd El-Rahman   +3 more
doaj   +1 more source

Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol‐facing catalytic domain in primate oxytocin neurons

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Tatsuki Miyamoto, Akari Matsushima, Akito Otubo, Chihong Song, Kazuyoshi Murata, Takumi Oti, Hirotaka Sakamoto   +6 more
wiley   +1 more source

Purification and cloning of brain isoform of ADP-ribosyl cyclase [PDF]

, 2000
神経腫瘍細胞NG108-15細胞のADPリボシルシクラーゼは、ムスカリン受容体とカップルしていたが、脳のADPリボシルシクラーゼは、カップルする受容体が、数多くの試みの中からは検出できなかった。一方、心臓のADPリボシルシクラーゼは、イソプロテレノール、ノルアドレナリンやアンデオテンシンII刺激により、活性化された。私達の目的は受容体とカップルする膜型ADPリボシルシクラーゼの分子を決めることにあるので、さしあたり、ラット心室心筋を出発材料にすることにした。心筋を細分して低調液で、30分間浸け ...
69303, 東田, 陽博, 30093066
core   +1 more source