Results 51 to 60 of about 3,533 (177)

Sex, Receptors and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

Frontiers in Neuroscience, 2013
As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (IN OT) is demonstrating a growing potential as a therapeutic agent in psychiatry.
Kai S Macdonald
doaj   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

ADP-Ribosyl Cyclase in Rat Vascular Smooth Muscle Cells [PDF]

Circulation Research, 2000
Abstract —We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs) has enzymatic properties that differ from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells. ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by gangliosides
F G, de Toledo, J, Cheng, M, Liang, E N, Chini, T P, Dousa   +4 more
openaire   +2 more sources

The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.: CD38-independent ADP-ribosyl cyclase from brain synaptosomes

, 2006
International audiencecADPR (cADP-ribose), a metabolite of NAD+, is known to modulate intracellular calcium levels and to be involved in calcium-dependent processes, including synaptic transmission, plasticity and neuronal excitability.
Moutin, Marie-Jo, Ronjat, Michel, Pochon, Nathalie, Muller-Steffner, Hélène, Baratier, Julie, Villaz, Michel, Ceni, Claire, Schuber, Francis, de Waard, Michel   +8 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source

Molecular Characterization of ADP-ribosyl Cyclase Coupled with Receptors

, 2003
細胞内のCaをセカンドメッセンジャーとするCaシグナリングは、数多くの受容体の下流に存在する重要な信号伝達機構の一つである。最近、リアノジン感受性の細胞内Caプールを開く細胞内リガンドはサイクリックADPリボース(cADPR)であると考えられるようになってきた。この数年、我々はcADPRがIP3のようなセカンドメッセンジャーであるとするこの仮説を検証してきた。そしてNADからcADPRを産生する膜酵素が受容体によりコントロールされていることをムスカリン受容体を大量発現するNG108-15細胞(J.B.C.
69303, 東田, 陽博, 30093066
core   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, Volume 24, Issue 10, October 2025.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium- mobilizing metabolite from NADP +

, 1995
ADP-ribosyl cyclase catalyzes the cyclization of NAD + to produce cyclic ADP-ribose (cADPR), which is emerging as an endogenous regulator of the Ca 2+-induced Ca 2+ release mechanism in cells.
Graeff, RM, Hon Cheung Lee, Walseth, TF, Dickey, DM, Aarhus, R   +4 more
core   +1 more source