Results 51 to 60 of about 10,542 (222)

The roles of oxytocin and CD38 in social or parental behaviors

Frontiers in Neuroscience, 2013
The nine amino acid peptide oxytocin (OXT) has been directly associated with different types of behavioral reactions. The formation and maintenance of social relationships in youth and middle age are important components of human mental health. A deficit
Olga eLopatina, Alyona eInzhutova, Alla B. Salmina, Haruhiro eHigashida   +3 more
doaj   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

ADP‐ribosyl cyclase coupled with receptors via G proteins [PDF]

FEBS Letters, 1997
Crude cell membranes in mammalian cells contain ADP‐ribosyl cyclase, which converts NAD+ to cyclic ADP‐ribose. Acetylcholine either increases or inhibits this activity in NG108‐15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor subtype‐specific manner.
openaire   +2 more sources

CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1

Scientific Reports, 2021
CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardia, Massimo Massaia, Enza Ferrero, Erika Ortolan, Ada Funaro   +9 more
doaj   +1 more source

Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal. [PDF]

, 2011
BACKGROUND: The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow waves.
Caldas, Carlos, Daigo, Yataro, Fujino, Masayuki A, Ponder, Bruce AJ, Sanders, Kenton M, Takayama, Ichiro, Ward, Sean M   +6 more
core   +1 more source

Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity.

Journal of Biological Chemistry, 1994
Cyclic nucleotides such as cAMP and cGMP are second messengers subserving various signaling pathways. Cyclic ADP-ribose (cADPR), a recently discovered member of the family, is derived from NAD+ and is a mediator of Ca2+ mobilization in various cellular ...
Richard, GraeffS, Timothy F. Walsethq, Kathryn FryxellS, D. Branton, Hon Cheung LeeSn   +5 more
semanticscholar   +1 more source

From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Marco Borso, Jan Ruprecht, Christopher Vorreiter, Sabrina Rast, Lin Zhang, Matthias Schiedel, Wolfgang Sippl, Axel Imhof, Henning J. Jessen, Oliver Einsle, Mike Schutkowski, Manfred Jung   +16 more
wiley   +2 more sources

Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal-mediated headshaking. [PDF]

, 2019
BackgroundOral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses.ObjectiveEvaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses ...
Aleman, Monica, Costa, Lais RR, Howey, Quinn, Madigan, John E, Sheldon, Shara A, Weich, Kalie   +5 more
core   +2 more sources

The Expression of CD38 ADP-ribosyl Cyclase Ectoenzyme in Immune Cells of Cardiac Surgical Patients

Acta Medica, 2008
Background: This study was aimed at following the changes in the expression of CD38 ADP-ribosyl cyclase ectoenzyme on peripheral blood immune cells of patients undergoing cardiac surgical operations.
Martina Koláčková, Manuela Trojáčková Kudlová, Vladimír Lonský, Jiří Manďák, Pavel Kuneš, Karolína Jankovičová, Dana Vlášková, Ctirad Andrýs, Jan Krejsek   +8 more
doaj   +1 more source

Immuno-targeting the multifunctional CD38 using nanobody [PDF]

, 2016
published_or_final_versio
Deng, QW, Hao, Q, Hou, YN, Koch-Nolte, F, Lam, MC, Lee, HC, Li, T, Liu, J, Qi, S, Unger, M, Wang, XW, Xin, D, Zhang, H, Zhang, P, Zhao, YJ   +14 more
core   +1 more source