Results 71 to 80 of about 3,533 (177)

Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38

, 1996
ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize ...
Prasad, GS, Stura, EA, Stout, CD, Mcree, DE, Levitt, DG, Lee, HC   +5 more
core   +1 more source

Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

Aging Cell, Volume 23, Issue 11, November 2024.
Aged M‐MDSCs have increased osteoclastogenesis potential. Transcriptomic analyses revealed the upregulation of mitochondrial oxidative phosphorylation and glucose metabolism genes, especially CD38 or NADase. A specific CD38 inhibitor reduced the mitochondrial oxygen consumption rate and glucose metabolism and inhibited the osteoclastogenic potential of
Ramkumar Thiyagarajan, Lixia Zhang, Omar D. Glover, Kyu Hwan Kwack, Sara Ahmed, Emma Murray, Nanda Kumar Yellapu, Jonathan Bard, Kenneth L. Seldeen, Spencer R. Rosario, Bruce R. Troen, Keith L. Kirkwood   +11 more
wiley   +1 more source

ADP Ribosyl Cyclase, Activity In Rat Parotid, Acinar Cells

, 1998
ADP ribosyl cyclase, cyclic ADP-ribose, intracellular calcium, parotid acinar ...
Dissing, S., Looms, D.K., Nauntofte, Birgitte   +2 more
core  

Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

Pediatric Obesity, Volume 19, Issue 9, September 2024.
Summary Objective Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association ...
Marcos Olvera‐Rojas, Abel Plaza‐Florido, Patricio Solis‐Urra, Francisco J. Osuna‐Prieto, Francisco B. Ortega   +4 more
wiley   +1 more source

Purification and cloning of brain isoform of ADP-ribosyl cyclase

, 2000
神経腫瘍細胞NG108-15細胞のADPリボシルシクラーゼは、ムスカリン受容体とカップルしていたが、脳のADPリボシルシクラーゼは、カップルする受容体が、数多くの試みの中からは検出できなかった。一方、心臓のADPリボシルシクラーゼは、イソプロテレノール、ノルアドレナリンやアンデオテンシンII刺激により、活性化された。私達の目的は受容体とカップルする膜型ADPリボシルシクラーゼの分子を決めることにあるので、さしあたり、ラット心室心筋を出発材料にすることにした。心筋を細分して低調液で、30分間浸け ...
69303, 東田, 陽博, 30093066
core   +1 more source

Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase

, 2011
Cyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role.
DANIELA CALZIA, SILVIA RAVERA, GIOVANNI CANDIANO, M. Bruschi, G. Candiano., ANGELA BACHI, ANGELA CATTANEO, A. Bachi, A. Fabiano, MAURIZIO BRUSCHI, I. Panfoli, D. Calzia, ANDREA FABIANO, A. Morelli, A. Cattaneo, ALESSANDRO MORELLI, S. Ravera, ISABELLA PANFOLI   +17 more
core   +1 more source

Redesign of Schistosoma mansoni NAD⁺ Catabolizing Enzyme: Active Site H103W Mutation Restores ADP-Ribosyl Cyclase Activity^†

, 2016
Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family. In contrast to all the other enzymes that are involved in the production of metabolites that elicit Ca2+ mobilization, SmNACE is virtually unable ...
Esther Kellenberger (170384), Didier Rognan (243719), Francis Schuber (170392), Frances E. Lund (107195), Hélène Muller-Steffner (170365), Isabelle Kuhn (170369)   +5 more
core   +1 more source

Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization

, 2008
In neurons, voltage-gated Ca2+ channels and nuclear Ca 2+ signaling play important roles, such as in the regulation of gene expression. However, the link between electrical activity and biochemical cascade activation involved in the generation of the ...
Bezin, Stéphanie, Baux, G, Cancela, JM, Lee, Hon Cheung, Fossier, P, Fossier, Philippe, Charpentier, G, Lee, HC, Baux, Gérard, Bezin, S, Charpentier, Gilles, Cancela, José-Manuel   +11 more
core   +1 more source

High-level expression of recombinant Aplysia ADP-ribosyl cyclase in Pichia pastoris by fermentation

, 1997
Cyclic ADP-ribose (cADPR), a Ca2+ mobilizing cyclic nucleotide derived from NAD+, is rapidly emerging as an endogenous modulator of Ca2+-induced Ca2+ release mechanisms in various cellular systems.
Munshi, C, Hon, CL
core   +1 more source

ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT

Hematology, Transfusion and Cell Therapy
Introduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj   +1 more source