Results 81 to 90 of about 98,812 (142)

Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase

, 2011
Cyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role.
DANIELA CALZIA, SILVIA RAVERA, GIOVANNI CANDIANO, M. Bruschi, G. Candiano., ANGELA BACHI, ANGELA CATTANEO, A. Bachi, A. Fabiano, MAURIZIO BRUSCHI, I. Panfoli, D. Calzia, ANDREA FABIANO, A. Morelli, A. Cattaneo, ALESSANDRO MORELLI, S. Ravera, ISABELLA PANFOLI   +17 more
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Redesign of Schistosoma mansoni NAD⁺ Catabolizing Enzyme: Active Site H103W Mutation Restores ADP-Ribosyl Cyclase Activity^†

, 2016
Schistosoma mansoni NAD(P)+ catabolizing enzyme (SmNACE) is a new member of the ADP-ribosyl cyclase family. In contrast to all the other enzymes that are involved in the production of metabolites that elicit Ca2+ mobilization, SmNACE is virtually unable ...
Esther Kellenberger (170384), Didier Rognan (243719), Francis Schuber (170392), Frances E. Lund (107195), Hélène Muller-Steffner (170365), Isabelle Kuhn (170369)   +5 more
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ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT

Hematology, Transfusion and Cell Therapy
Introduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj   +1 more source

Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization

, 2008
In neurons, voltage-gated Ca2+ channels and nuclear Ca 2+ signaling play important roles, such as in the regulation of gene expression. However, the link between electrical activity and biochemical cascade activation involved in the generation of the ...
Bezin, Stéphanie, Baux, G, Cancela, JM, Lee, Hon Cheung, Fossier, P, Fossier, Philippe, Charpentier, G, Lee, HC, Baux, Gérard, Bezin, S, Charpentier, Gilles, Cancela, José-Manuel   +11 more
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Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase

, 2009
Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulatesmanyphysiological processes.Theproduction and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california ...
Jiang, H, Hao, Q, Kriksunov, IA, Zhang, B, Liu, Q, Lin, H, Potter, BVL, Graeff, R, Lee, HC, Oppenheimer, N   +9 more
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High-level expression of recombinant Aplysia ADP-ribosyl cyclase in Pichia pastoris by fermentation

, 1997
Cyclic ADP-ribose (cADPR), a Ca2+ mobilizing cyclic nucleotide derived from NAD+, is rapidly emerging as an endogenous modulator of Ca2+-induced Ca2+ release mechanisms in various cellular systems.
Munshi, C, Hon, CL
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Crystal structure of ADP-ribosyl cyclase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
C. D. Stout, G. Sridhar Prasad, E. A. Stura, D. E. McRee, D. G. Levitt, H. C. Lee   +5 more
openaire   +1 more source

Poly(ADP-Ribose) Polymerase (PARP) signaling of DNA damage induced by Topoisomerase 1 (TOP1) inhibition in carcinoma cells: chemotherapeutic implications of PARP and TOP1 inhibitors. [PDF]

, 2010
Una nuova strategia molecolare che incrementa l’azione antitumorale degli inibitori della Topoisomerasi 1 (TOP1) si basa sull’utilizzo di inibitori delle poli(ADP-ribosio) polimerasi (PARP).
D'Onofrio, Giovanna
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CD38 as theranostic target in oncology

Journal of Translational Medicine
CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers, Guillaume Marcion   +7 more
doaj   +1 more source

Identification and characterization of novel ADP-ribosyl cyclase family members

, 2011
University of Minnesota Ph.D. dissertation. August 2011. Major: Pharmacology. Advisor: Timothy F. Walseth Ph.D. 1 computer file (PDF); iv, 154 pages.CD38 and CD157 have been identified as mammalian forms of ADP-ribosyl cyclase (ADPRC).
Hirte, Renee Marie
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