Results 81 to 90 of about 3,533 (177)

Crystal structure of ADP-ribosyl cyclase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
C. D. Stout, G. Sridhar Prasad, E. A. Stura, D. E. McRee, D. G. Levitt, H. C. Lee   +5 more
openaire   +1 more source

Identification and characterization of novel ADP-ribosyl cyclase family members

, 2011
University of Minnesota Ph.D. dissertation. August 2011. Major: Pharmacology. Advisor: Timothy F. Walseth Ph.D. 1 computer file (PDF); iv, 154 pages.CD38 and CD157 have been identified as mammalian forms of ADP-ribosyl cyclase (ADPRC).
Hirte, Renee Marie
core  

NO-Mediated [Ca2+]cyt Increases Depend on ADP-Ribosyl Cyclase Activity in Arabidopsis.

, 2016
Cyclic ADP ribose (cADPR) is a Ca(2+)-mobilizing intracellular second messenger synthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases). In animals, cADPR targets the ryanodine receptor present in the sarcoplasmic/endoplasmic reticulum to promote Ca(
Hotta, Carlos T., Smith, Alison G, Dodd, Antony N., Davey, Matthew P., Abdul-Awal, S. M., Webb, Alex A R   +5 more
core   +1 more source

CD38 as theranostic target in oncology

Journal of Translational Medicine
CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers, Guillaume Marcion   +7 more
doaj   +1 more source

A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes

, 1993
The three ectoenzyme activities, NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase were purified to homogeneity from solubilized human erythrocyte membranes. The purification procedure involved three sequential chromatography steps
Malavasi, F, De Flora, A, Franco, L, Guida, L, Bargellesi, A, Lee, HC, Zocchi, E, Benatti, U   +7 more
core   +1 more source

Determination of ADP-Ribosyl Cyclase Activity, Cyclic ADP-Ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Tissue Extracts

, 2013
Cyclic ADP-ribose (cADPR) is a novel second messenger that releases calcium from intracellular stores. Although first shown to release calcium in the sea urchin egg, cADPR has been shown since to be active in a variety of cells and tissues, from plant to
Richard M. Graeff, Graeff, RM, Hon Cheung Lee, Lee, HC   +3 more
core   +1 more source

Self-aggregation of purified and membrane-bound erythrocyte CD38 induces extensive decrease of its ADP-ribosyl cyclase activity

, 1995
The transmembrane glycoprotein CD38 is a bifunctional enzyme that catalyzes at its ectocellular domain both the synthesis and the hydrolysis of cyclic ADP-ribose (cADPR).
Lucrezia Guida, Calder, Lesley, Elena Zocchi, Zocchi, Elena, Guida, Lucrezia, Franco, Luisa, Luisa Franco, Lesley Calder, Antonio De Flora, De Flora, Antonio   +9 more
core   +1 more source

CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP- ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose

, 1997
CD38, a lymphocyte differentiation antigen, is also a bifunctional enzyme catalyzing the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and its hydrolysis to ADP-ribose (ADPR).
Bruzzone, S, De Flora, A, Guida, L, Franco, L, Gianluca Damonte, Umberto Benatti, Lee, HC, Zocchi, E, Lucrezia Guida, Santina Bruzzone, Hon Cheung Lee, Elena Zocchi, Luisa Franco, Damonte, G, Antonio De Flora, Benatti, U   +15 more
core   +1 more source

ADP-ribosyl cyclase and CD38: Multi-functional enzymes in Ca+2 signaling

, 1997
Mobilization of internal Ca+2 is an important signaling mechanism in cells. In addition to the inositol trisphosphate pathway, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide (NAADP) have been shown to mobilize Ca+2 via independent ...
Graeff, RM, Walseth, TF, Lee, HC
core  

Functional characterization of ADP ribosyl cyclase signaling pathways in the renal microcirculation

, 2009
Due to its role in the regulation of salt and water balance, the kidney is thought to be the primary organ involved in arterial blood pressure regulation.
Thai, Tiffany L.
core   +1 more source