Results 81 to 90 of about 10,542 (222)

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source

Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.

Journal of Immunology, 1998
Human CD38 is a cell surface molecule involved in the regulation of lymphocyte adhesion to endothelial cells. This suggests that HUVEC bear a ligand(s) for CD38 on the cell surface.
S. Deaglio, M. Morra, R. Mallone, C. Ausiello, E. Prager, G. Garbarino, U. Dianzani, H. Stockinger, F. Malavasi   +8 more
semanticscholar   +1 more source

ADP-ribosyl Cyclase and Cyclic ADP-ribose Hydrolase Act as a Redox Sensor

Journal of Biological Chemistry, 2001
Hypoxic pulmonary vasoconstriction is unique to pulmonary arteries and serves to match lung perfusion to ventilation. However, in disease states this process can promote hypoxic pulmonary hypertension.
H. Wilson, M. Dipp, Justyn M. Thomas, Chetan Lad, A. Galione, A. Evans   +5 more
semanticscholar   +1 more source

Модуляция активности АДФ-рибозилциклазы при ишемии головного мозга [PDF]

, 2012
Второе место среди причин смертности и инвалидизации больных занимают острые нарушения мозгового кровообращения. Цель исследования - оценить влияние модуляторов активности АДФ-рибозилциклазы/CD38 в нейронах и клетках нейроглиальной природы в ...
Баглаева, Ольга Владимировна, Гасымлы, Эльтадж Джамил кызы, Кувачева, Наталья Валерьевна, Малиновская, Наталия Александровна, Морозова, Галина Александровна, Панина, Юлия Анатольевна, Петрова, Марина Михайловна, Салмина, Алла Борисовна, Фролова, Ольга Васильевна   +8 more
core  

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR).
Aarhus, Balázs Tóth, Beck, Brailoiu, Calcraft, Churamani, Csanády, Fliegert, Fonfria, Hara, Hermosura, Iordan Iordanov, Kaneko, Koch-Nolte, Kolisek, Lange, Lin, László Csanády, Malavasi, McHugh, Moreau, Nagamine, Olah, Perraud, Perraud, Perraud, Perraud, Sano, Schmid, Togashi, Tóth, Tóth, Tóth, Uchida, Wang, Wehage, Yamamoto   +36 more
core   +2 more sources

Evidence for an Intracellular ADP-ribosyl Cyclase/NAD+-glycohydrolase in Brain from CD38-deficient Mice*

Journal of Biological Chemistry, 2003
Cyclic ADP-ribose, a metabolite of NAD+, is known to modulate intracellular calcium levels and signaling in various cell types, including neural cells.
C. Céni, H. Muller-Steffner, F. Lund, N. Pochon, Annie Schweitzer, M. De Waard, F. Schuber, M. Villaz, M. Moutin   +8 more
semanticscholar   +1 more source

Design, synthesis and biological characterization of novel inhibitors of CD38 [PDF]

, 2011
Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca 2+ messenger molecule, cyclic ADP-ribose, from NAD +.
Cheung Lee, H, Dong, M, Hao, Q, Kriksunov, IA, Kwong, AKY, Lam, CMC, Leung, FP, Pu, XP, Si, YQ, Sun, SY, Yang, ZJ, Yue, J, Zhang, LH, Zhang, LR, Zhou, Y   +14 more
core   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, Volume 24, Issue 10, October 2025.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

Cyclic ADP ribose is a novel regulator of intracellular Ca 2+ oscillations in human bone marrow mesenchymal stem cells [PDF]

, 2011
Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, the cellular biology of these cells is not fully understood. The present study characterizes the cyclic ADP-ribose (cADPR)-mediated Ca 2+ signals in
Lau, CP, Lee, HC, Li, GR, Sun, HY, Tao, R, Tse, HF   +5 more
core   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source