Results 61 to 70 of about 10,542 (222)

Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. [PDF]

PLoS ONE, 2013
Preceding studies on the mode of action of non-genotoxic hepatocarcinogens (NGCs) have concentrated on alterations induced in hepatocytes (HCs). A potential role of non-parenchymal liver cells (NPCs) in NGC-driven hepatocarcinogenesis has been largely ...
Philip Klepeisz, Sandra Sagmeister, Verena Haudek-Prinz, Melanie Pichlbauer, Bettina Grasl-Kraupp, Christopher Gerner   +5 more
doaj   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population

Diseases, 2020
The transient receptor potential melastatin 2 (TRPM2) is a non-specific cation channel, resulting in Ca2+ influx at warm temperatures from 34 °C to 47 °C, thus including the body temperature range in mammals.
Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida   +6 more
doaj   +1 more source

Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform. [PDF]

Biochem J, 2004
The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Bacher I, Zidar A, Kratzel M, Hohenegger M.   +3 more
europepmc   +5 more sources

Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy [PDF]

Cardiovascular Research, 2008
Here, we report the discovery of a small molecule inhibitor, 2,2'-dihydroxyazobenzene (DAB), of ADP ribosyl cyclase (ADPR-cyclase) and showed that this inhibitor attenuated angiotensin (Ang) II-induced hypertrophic responses.and results The intracellular concentration of free Ca(2+) [Ca(2+)](i) in adult rat cardiomyocytes was measured by using a ...
Rukhsana, Gul, Jae-Hyeong, Park, Seon-Young, Kim, Kyu Yoon, Jang, Jei-Keon, Chae, Jae-Ki, Ko, Uh-Hyun, Kim   +6 more
openaire   +2 more sources

Impaired learning and memory in CD38 null mutant mice [PDF]

, 2016
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores.
Jang, Eun-Hye, Kaang, Bong-Kiun, Kang, Minkyung, Kim, Jae-Ick, Kim, Sang Jeong, Kim, Somi, Kim, TaeHyun, Kim, Uh-Hyun, Lee, Bolam, Lee, Hye-Ryeon, Lee, Yong-Seok, Lim, Chae Seok, Rah, So-Young, Ryu, Hyun-Hee, Yoo, Juyoun   +14 more
core   +1 more source

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease

Frontiers in Behavioral Neuroscience, 2014
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in
Olga eLopatina, Toru eYoshihara, Tomoko eNishimura, Jing eZhong, Shirin eAkther, Azam AKM Fakhrul, Mingkun eLiang, Chiharu eHigashida, Kohei eSumi, Kazumi eFuruhara, Yuki eInahata, Jianjun eHuang, Keita eKoizumi, Shigeru eYokoyama, Takahiro eTsuji, Yu ePetugina, Andrei eSumarukov, Alla B. Salmina, Koji eHashida, Yasuko eKitao, Osamu eHori, Masahide eAsano, Yoji eKitamura, Takashi eKozaka, Kazuhiro eShiba, Fangfang eZhong, Min-Jue eXie, Makoto eSato, Katsuhiko eIshihara, Haruhiro eHigashida   +29 more
doaj   +1 more source

Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? [PDF]

, 2000
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially ...
RA Panettieri Jr, SR Johnson, Y Amrani, PN Bouchelouche, BE Corkey, H Koller, F Peiretti, MA Schumann, R Beyaert, BE Rapuano, MF Wilkinson, B Cheng, G Garcia, KA Krown, LM Renzetti, Y Amrani, Y Amrani, Y Amrani, K Hotta, Y Nakatani, JRM Parris, LA Tartaglia, Y Amrani, H Hsu, H Hsu, Y Amrani, N Auphan, O Thastrup, Y Amrani, BA Reilly, H Aktas, HL Pahl, OA Adebanjo   +32 more
core   +1 more source

Purification and characterization of CD38/ADP‐ribosyl cyclase from rat lung [PDF]

IUBMB Life, 1998
AbstractPurification and characterization of CD38/ADP‐ribosyl cyctase in the rat lung tissue was performed with microsomes solubilized in Triton X‐100 and the ADP‐ribosyl cyclase was then purified using sequential column chromatography. Partially purified rat lung ADP‐ribosyl cyclase was analyzed by immunoblotting using an antibody raised against a ...
Khoo, K.M., Chang, C.F.
openaire   +2 more sources