Results 61 to 70 of about 98,812 (142)

A molecular toolbox for ADP-ribosyl binding proteins [PDF]

, 2021
SummaryProteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or viral infections, making them attractive drug targets.
Sowa, Sven T., Wazir, Sarah, Lehtiö, Lari, Galera-Prat, Albert, Alanen, Heli I., Maksimainen, Mirko M.   +5 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium- mobilizing metabolite from NADP +

, 1995
ADP-ribosyl cyclase catalyzes the cyclization of NAD + to produce cyclic ADP-ribose (cADPR), which is emerging as an endogenous regulator of the Ca 2+-induced Ca 2+ release mechanism in cells.
Graeff, RM, Hon Cheung Lee, Walseth, TF, Dickey, DM, Aarhus, R   +4 more
core   +1 more source

ADP-Ribosyl Cyclase in Rat Vascular Smooth Muscle Cells [PDF]

Circulation Research, 2000
Abstract —We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs) has enzymatic properties that differ from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells. ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by gangliosides
F G, de Toledo, J, Cheng, M, Liang, E N, Chini, T P, Dousa   +4 more
openaire   +2 more sources

Humoral immune profiling of endemic schistosome-exposed individuals reveals epitopes associated with resistance to reinfection

International Journal of Infectious Diseases
Background: The development of an effective vaccine against schistosomiasis would represent a major advance toward controlling and eliminating this neglected tropical disease. Given the complexity of host–parasite interactions, we propose a multi-epitope
Mariana Ivo Khouri, Fernanda Maria Lessa Carvalho, Almiro Pires da Silva Neto, Cleber Pereira da Silva, Ronald Alves dos Santos, Bruna Oliveira Lopes Souza, Thainá Rodrigues de Souza Fialho, Ane Caroline Casaes, Isadora Cristina de Siqueira, Luciana Cezar de Cerqueira Leite, Robert Alan Wilson, Ricardo Riccio Oliveira, Leonardo Paiva Farias   +12 more
doaj   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source

Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque

BMC Immunology, 2004
Background The CD38 transmembrane glycoprotein is an ADP-ribosyl cyclase that moonlights as a receptor in cells of the immune system. Both functions are independently implicated in numerous areas related to human health.
Titti Fausto, Crovella Sergio, Ortolan Erika, Vacca Paola, Orciani Monia, Ferrero Enza, Saccucci Franca, Malavasi Fabio   +7 more
doaj   +1 more source

The Na+/K+‐ATPase β1 Subunit is a Kidney ADP‐Ribosyl Cyclase

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
This study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Tae‐Sik Nam, Seong‐Kyu Choe, Uh‐Hyun Kim   +2 more
wiley   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, Volume 24, Issue 10, October 2025.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

Identification in human erythrocytes of mono(ADP-ribosyl) protein hydrolase that cleaves a mono(ADP-ribosyl) Gi linkage [PDF]

, 1990
A novel enzymatic activity, the hydrolysis of linkages between mono(ADP-ribose) and cysteine residues in Gi prepared by eukaryotic ADP-ribosyl-transferase C [(1988) J. Biol. Chem. 263, 5485-5489] was found in the cytosol of human erythrocytes.
Endo, Hiroyoshi, Hiroyoshi Endo, Sei-ichi Tanuma, Tanuma, Sei-ichi   +3 more
core   +1 more source