Results 61 to 70 of about 2,704 (153)
MedComm, Volume 6, Issue 7, July 2025.TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang +12 more
wiley +1 more source
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford +4 more
wiley +1 more source
The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques
ChemBioChem, Volume 26, Issue 3, February 1, 2025.This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley +1 more source
ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.
Cell Regulation, 1991 Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin eggs but also in various mammalian tissue extracts, suggesting that cADPR may be a general messenger for ...
Lee, HC, Aarhus, R
openaire +6 more sources
ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT
Hematology, Transfusion and Cell TherapyIntroduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj +1 more source
CD38 as theranostic target in oncology
Journal of Translational MedicineCD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi +7 more
doaj +1 more source
Crystal structure of ADP-ribosyl cyclase [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 1996 C. D. Stout +5 more
openaire +1 more source
Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. [PDF]
Dev Biol, 2019 Kelu JJ, Webb SE, Galione A, Miller AL.
europepmc +1 more source
Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. [PDF]
J Med Chem, 2014 Swarbrick JM +5 more
europepmc +1 more source