Results 61 to 70 of about 3,533 (177)

Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque

BMC Immunology, 2004
Background The CD38 transmembrane glycoprotein is an ADP-ribosyl cyclase that moonlights as a receptor in cells of the immune system. Both functions are independently implicated in numerous areas related to human health.
Titti Fausto, Crovella Sergio, Ortolan Erika, Vacca Paola, Orciani Monia, Ferrero Enza, Saccucci Franca, Malavasi Fabio   +7 more
doaj   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

Immune Cell Proteins and Parkinson's Disease: A Mendelian Randomization Analysis of Causal Associations

Brain and Behavior, Volume 15, Issue 7, July 2025.
Mendelian randomization (MR) analysis was applied to elucidate the causal relationship between immune cell proteins and PD. Our study reveals a possible causal effect of immune cell proteins on the risk of PD and provides new ideas for the prevention and management of PD through immune cell proteins.
Haining Li, Jianhang He, Tingting Xuan, Shue Gu, Xiaoyan Niu, Yazhou Ren, Xiuping Zhan, Jiang Cheng   +7 more
wiley   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford, Mohammad Irshad Reza, Anushka Ruwanpathirana, Venkatachalem Sathish, Rodney D. Britt Jr   +4 more
wiley   +1 more source

ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.

Cell Regulation, 1991
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin eggs but also in various mammalian tissue extracts, suggesting that cADPR may be a general messenger for ...
Lee, HC, Aarhus, R
openaire   +6 more sources

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms

Journal of Neuroinflammation, 2011
Background Infection with human immunodeficiency virus type-1 (HIV)-1 leads to some form of HIV-1-associated neurocognitive disorders (HAND) in approximately half of the cases.
Mamik Manmeet K, Banerjee Sugato, Walseth Timothy F, Hirte Renee, Tang Lin, Borgmann Kathleen, Ghorpade Anuja   +6 more
doaj   +1 more source

Tartary Buckwheat Bran and Fructus Aurantii Combination (TBB‐FA): A Promising Therapeutic Approach for Functional Dyspepsia via Modulation of Gut Microbiota, Short‐Chain Fatty Acids and Purine Signaling Pathway

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Fructus aurantii, stir‐baked with Tartary buckwheat bran, was employed as a treatment for functional dyspepsia (FD). The potential of this combination to replace or supplement wheat bran was thoroughly assessed. The purinergic signaling system holds potential as a therapeutic target for gastrointestinal disorders, thereby facilitating the development ...
Di Wang, Xiaobo Zeng, Xinge Wang, Wen Wen, Ping Wang, Shijun Xu   +5 more
wiley   +1 more source

Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin

, 2010
Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
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