Results 41 to 50 of about 2,983 (148)

Functional characterization of ADP ribosyl cyclase signaling pathways in the renal microcirculation

, 2009
Due to its role in the regulation of salt and water balance, the kidney is thought to be the primary organ involved in arterial blood pressure regulation.
Thai, Tiffany L.
core   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford, Mohammad Irshad Reza, Anushka Ruwanpathirana, Venkatachalem Sathish, Rodney D. Britt Jr   +4 more
wiley   +1 more source

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

Tartary Buckwheat Bran and Fructus Aurantii Combination (TBB‐FA): A Promising Therapeutic Approach for Functional Dyspepsia via Modulation of Gut Microbiota, Short‐Chain Fatty Acids and Purine Signaling Pathway

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Fructus aurantii, stir‐baked with Tartary buckwheat bran, was employed as a treatment for functional dyspepsia (FD). The potential of this combination to replace or supplement wheat bran was thoroughly assessed. The purinergic signaling system holds potential as a therapeutic target for gastrointestinal disorders, thereby facilitating the development ...
Di Wang, Xiaobo Zeng, Xinge Wang, Wen Wen, Ping Wang, Shijun Xu   +5 more
wiley   +1 more source

The Expression of CD38 ADP-ribosyl Cyclase Ectoenzyme in Immune Cells of Cardiac Surgical Patients

, 2008
Background: This study was aimed at following the changes in the expression of CD38 ADP-ribosyl cyclase ectoenzyme on peripheral blood immune cells of patients undergoing cardiac surgical operations.
Manuela Trojáčková Kudlová, Karolína Jankovičová, Vladimír Lonský, Martina Koláčková, Jiří Manďák, Dana Vlášková, Ctirad Andrýs, Pavel Kuneš, Jan Krejsek   +8 more
core   +1 more source

Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS [PDF]

, 2013
ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP ...
Cericola, Claudia, Catara, Giuliana, Liberali, Prisca, Luini, Alberto, Bolognesi, Martino, Urbani, Andrea, Colanzi, Antonino, RONCI, Maurizio, Nardini, Marco, Beccari, Andrea R, Valente, Carmen, Lalioti, Vasiliki S, Bruno, Agostino, Corda, Daniela, Grimaldi, Giovanna, De Flora, Antonio   +15 more
core   +2 more sources

Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin

, 2010
Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
core  

Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

Aging Cell, Volume 23, Issue 11, November 2024.
Aged M‐MDSCs have increased osteoclastogenesis potential. Transcriptomic analyses revealed the upregulation of mitochondrial oxidative phosphorylation and glucose metabolism genes, especially CD38 or NADase. A specific CD38 inhibitor reduced the mitochondrial oxygen consumption rate and glucose metabolism and inhibited the osteoclastogenic potential of
Ramkumar Thiyagarajan, Lixia Zhang, Omar D. Glover, Kyu Hwan Kwack, Sara Ahmed, Emma Murray, Nanda Kumar Yellapu, Jonathan Bard, Kenneth L. Seldeen, Spencer R. Rosario, Bruce R. Troen, Keith L. Kirkwood   +11 more
wiley   +1 more source

Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

Pediatric Obesity, Volume 19, Issue 9, September 2024.
Summary Objective Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association ...
Marcos Olvera‐Rojas, Abel Plaza‐Florido, Patricio Solis‐Urra, Francisco J. Osuna‐Prieto, Francisco B. Ortega   +4 more
wiley   +1 more source