Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications [PDF]
, 2012 Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jin, H +6 more
core +2 more sources
Journal of Cellular and Molecular Medicine, Volume 28, Issue 16, August 2024.Abstract The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID‐19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically in the treatment of this disorder.
Margaret M. Smith, James Melrose
wiley +1 more source
NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy [PDF]
, 2013 published_or_final_versio
Graeff, RM, Hao, B, Lu, Y, Yue, J
core +1 more source
"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]
, 2014 Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core
The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein beta Subunit [PDF]
, 1997 Ca2+ ion concentration changes are critical events in signal transduction. The Ca2+-dependent interactions of calmodulin (CaM) with its target proteins play an essential role in a variety of cellular functions.
Liu, Mingyao +4 more
core
The two-pore channel TPCN2 mediates NAADP-dependent Ca-release from lysosomal stores [PDF]
, 2009 Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the ...
Xiangang Zong +42 more
core +1 more source
Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. III. Skeletal Integrity [PDF]
, 2007 Two unique chicken F2 populations generated from a broiler breeder male line and 2 genetically distinct inbred (\u3e99%) chicken lines (Leghorn and Fayoumi) were used for whole genome QTL analysis.
Ashwell, C. M. +6 more
core +3 more sources
ZFP36 proteins and mRNA targets in B cell malignancies [PDF]
, 2015 The ZFP36 proteins are a family of post-transcriptional regulator proteins that bind to adenine uridine rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs.
Alcaraz, A., Alcaraz, A.
core
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. [PDF]
, 2002 The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity.
Frye, Roy A +4 more
core
NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis. [PDF]
, 2019 The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression.
Cai, Zongwei +7 more
core