Results 61 to 70 of about 2,983 (148)

Diadenosine homodinucleotide products of ADP-ribosyl cyclase behave as modulators of the purinergic receptor P2X7

, 2010
ADP-ribosyl cyclases from both vertebrates and invertebrates were previously shown to produce two isomers of P1,P2 diadenosine 5',5'"-P1, P2-diphosphate, P18 and P24, from cyclic ADP-ribose (cADPR) and adenine. P18 and P24 are characterized by an unusual
Zocchi E., Usai C., De Flora A., DI VIRGILIO, Francesco, Bruzzone S., Jacchetti E., Basile G., Schenone A., Chothi M. P., Nobbio L., Guse A. H.   +10 more
core   +1 more source

P2Y12 receptor modulation of ADP‐evoked intracellular Ca2+ signalling in THP-1 human monocytic cells [PDF]

, 2018
Background and purpose: The Gi‐coupled, ADP‐activated P2Y12 receptor is well characterised as playing a key role in platelet activation via crosstalk with P2Y1 in ADP‐evoked intracellular Ca2+ response.
J J Micklewright, J A Layhadi, Micklewright, J. J., Fountain, S. J., Layhadi, J. A., S J Fountain   +5 more
core   +1 more source

Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes: effects on insulin release from human islets.

, 1999
The type II transmembrane glycoprotein CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) has been proposed as a mediator of insulin secretion from pancreatic beta-cells and as a candidate for autoimmune reactions in type 2 diabetes. We evaluated the
Lupi R, Okamoto H, MARCHETTI, PIERO, Takasawa S, Giannini S, Pupilli C, Malavasi F, ANTONELLI, ALESSANDRO, FERRANNINI, ELEUTERIO   +8 more
core   +1 more source

Профилактика постишемического неврологического дефицита путем модуляции экспрессии АДФ-рибозилциклазы в клетках головного мозга (экспериментальное исследование)

, 2007
Objective: to study the mechanism that is responsible for impaired neuronal cell electroexcitability and viability, which is associated with modification of ADP-ribosyl cyclase in cerebral ischemic lesion, as well as the possibilities of pathogenet ...
А. А. Фурсов, М. А. Фурсов, N. A. Shnayder, А. В. Моргун, N. A., Malinovskaya, Н. А. Малиновская, M. A. Fursov, Л. Д. Зыкова, С. В. Шахмаева, С. В. Михуткина, S. V. Mikhutkina, A. A. Fursov, S. V. Shakhmaeva, Н. А. Шнайдер, D. I. Laletin, Г. В. Юдин, A. V. Morgun, G. V. Yudin, А. Б. Салмина, A. B. Salmina, L. D. Zykova, Д. И. Лалетин   +21 more
core   +1 more source

Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase

, 2011
Calcium is a ubiquitous, versatile intracellular signal regulating numerous cellular processes [1]. The versatility of Ca2+ signalling emerges from the use of an extensive repertoire of signalling components known as a Ca2+ signalling toolkit that can be
Hao, Q, Zhang, L, Kotaka, M, Graeff, R, Lee, HC   +4 more
core  

Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia.

, 1998
1. Presynaptic injection of cyclic ADP-ribose (cADPR), a modulator of the ryanodine receptor, increased the postsynaptic response evoked by a presynaptic spike at an identified cholinergic synapse in the buccal ganglion of Aplysia californica. 2.
Meunier, François-Marie, Tauc, Ladislav, Mothet, Jean-Pierre, Fossier, Philippe, Stinnakre, Jacques, Baux, Gérard   +5 more
core   +1 more source

Functional expression of secreted mouse BST-1 in yeast

, 1998
BST-1, a bone marrow stromal cell surface antigen, is a glycosyl phosphotidylinositol-anchored protein that stimulates pre-B-cell growth and has adenosine diphosphate (ADP)-ribosyl cyclase and cyclic ADP-ribose (cADPR) hydrolase activity.
Chang, CF, Hussain, AMM, Lee, HC
core   +1 more source

Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation

, 2012
In adult brains, ionotropic or metabotropic purinergic receptors are widely expressed in neurons and glial cells. They play an essential role in inflammation and neurotransmission in response to purines secreted to the extracellular medium.
Puerto, Ana del, Díaz-Hernández, Juan-Ignacio, Zhang, Jin, Miras-Portugal, María Teresa, Tapia, Mónica, Gómez-Villafuertes, Rosa, Benítez, María J., Wandosell, Francisco, Garrido Jurado, Juan José, Díaz-Hernández, Miguel   +9 more
core   +1 more source

Nitric oxide inhibits Ca²⁺mobilization through cADP-ribose signaling in coronary arterial smooth muscle cells

, 2000
The present study was designed to determine whether the cADP-ribose-mediated Ca2+signaling is involved in the inhibitory effect of nitric oxide (NO) on intracellular Ca2+mobilization.
Ai-Ping Zou, Pin-Lan Li, William B. Campbell, David X. Zhang, Jiang-Zhou Yu   +4 more
core   +1 more source

Crystal structure of human CD38 extracellular domain

, 2005
Human CD38 is a multifunctional protein involved in diverse functions. As an enzyme, it is responsible for the synthesis of two Ca2+ messengers, cADPR and NAADP; as an antigen, it is involved in regulating cell adhesion, differentiation, and ...
Graeff, Richard, Hao, Q, Munshi, Cyrus, Kriksunov, IA, Liu, Q, Hon, CL, Lee, Hon Cheung, Graeff, R, Irina A. Kriksunov, Munshi, C, Richard Graeff, Hon Cheung Lee, Liu, Qun, Hao, Quan, Kriksunov, Irina A., Quan Hao, Cyrus Munshi, Qun Liu   +17 more
core   +1 more source