Results 71 to 80 of about 2,983 (148)

Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors

, 2005
Cyclic ADP-ribose (cADPR) is an intracellular calcium mobilizer generated from NAD(+) by the ADP-ribosyl cyclases CD38 and BST-1. cADPR, both exogenously added and paracrinally produced by a CD38(+) feeder layer, has recently been demonstrated to ...
ZOCCHI, ELENA, BACIGALUPO, ANDREA, DE FLORA, ANTONIO, BENVENUTO, FEDERICA, FRANCO L., BRUZZONE, SANTINA, USAI C., PODESTA M., BODRATO N., PITTO A., PALEARI, LAURA, GUIDA, LUCREZIA, FIGARI O.   +12 more
core   +1 more source

Partitioning reaction mechanism of bCD38.

, 2012
The nicotinamide-ribosyl bond of NAD+ is cleaved via a dissociative process with a late transition state, leading to a ribooxocarbenium ion reaction intermediate stabilized by the side-chain of invariant Glu218.
Esther Kellenberger (170384), Francis Schuber (170392), Robert M. Stroud (30978), Hélène Muller-Steffner (170365), Céline Cakir-Kiefer (170373), Norman J. Oppenheimer (170379), Pascal F. Egea (170361), Isabelle Kuhn (170369)   +7 more
core   +1 more source

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

Locally released oxytocin (OT) activates OT receptors (2.1:OXY:1:OT:) in neighboring neurons in the hypothalamus and their terminals in the posterior pituitary, resulting in further OT release, best known in autoregulation occurring during labor or milk ...
Amina, Sarwat, Lopatina, Olga, Hashii, Minako, Liu, Hong-Xiang, Higashida, Haruhiro   +4 more
core  

Regulation of adenylyl cyclase from Blastocladiella emersonii by guanine nucleotides

, 1993
GTPγS stimulates adenylyl cyclase in particulate fractions of Blastocladiella emersonii zoospores. Cholera toxin catalyses the ADP-ribosylation of a membrane protein of a molecular weight (46,000) similar to that of the α subunit of Gs found in ...
Terenzi, Hernán, Hernán Terenzi, da Costa Maia, José Carlos, José Carlos da Costa Maia   +3 more
core   +1 more source

ORIGINAL CONTRIBUTION Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium

, 2002
Cyclic ADP-ribose (cADPR) is a novel Ca 2+ -mobilizing second messenger in mammalian cells including cardiomyocytes. It is unknown whether myocardial ischemia and reperfusion affect the metabolism of cADPR in the myocardium.
Garrett J Gross, Ai-Ping Zou, · Ya-Fei Chen, Pin-Lan Li, Ph.D. (౧) · Garrett J Gross, Zhi-Dong Ge, Ya-Fei Chen   +6 more
core  

Emerging chemical strategies for CD38 inhibition: restoring NAD⁺ metabolism and disease control. [PDF]

Bioorg Med Chem
Zhang Z, Ansari AJ, Fayne ER, Zhang Y.
europepmc   +1 more source

NAD⁺ metabolism at the host-virus interface. [PDF]

J Gen Virol
Jhandai P, Vaddadi K, Liu L.
europepmc   +1 more source

NAD glycohydrolase and ADP-ribosyltransferase activities are intrinsic to the A 1 peptide of choleragen

, 1979
In prior reports (Moss, J., Manganiello, V. C., and Vaughan, M. (1976) Proc. Natl. Acd Sci. U. S. A. 73, 4424-4427), it was demonstrated that choleragen preparations possessed NAD glycohydrolase activity. Tait and Van Heyningen ((1978) Biochem. J.
Lin, MC, Moss, J, Stanley, SJ
core  

Pathological Mechanisms in Sjögren's Disease Likely Involve the ADP-Ribosyl Cyclase Family Members: CD38 and CD157. [PDF]

Int J Mol Sci
Rosecka M, Kolackova M, Afshari M, Jozifkova E, Slezak R, Krejsek J, Radochova V.   +6 more
europepmc   +1 more source

Antibacterial ADP-ribosyl cyclase toxins inhibit bacterial growth by rapidly depleting NAD(P)^. [PDF]

J Biol Chem
Colautti J, Kim Y, Whitney JC.
europepmc   +1 more source