Results 51 to 60 of about 4,383 (149)

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Metabolic fate of extracellular NAD in human skin fibroblasts [PDF]

, 2001
Extracellular NAD is degraded to pyridine and purine metabolites by different types of surface-located enzymes which are expressed differently on the plasmamembrane of various human cells and tissues.
A. PRETI, ALEO M.F, DANESI P, GIUDICI M.L, POMPUCCI G, SESTINI S   +5 more
core  

Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford, Mohammad Irshad Reza, Anushka Ruwanpathirana, Venkatachalem Sathish, Rodney D. Britt Jr   +4 more
wiley   +1 more source

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

Tartary Buckwheat Bran and Fructus Aurantii Combination (TBB‐FA): A Promising Therapeutic Approach for Functional Dyspepsia via Modulation of Gut Microbiota, Short‐Chain Fatty Acids and Purine Signaling Pathway

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Fructus aurantii, stir‐baked with Tartary buckwheat bran, was employed as a treatment for functional dyspepsia (FD). The potential of this combination to replace or supplement wheat bran was thoroughly assessed. The purinergic signaling system holds potential as a therapeutic target for gastrointestinal disorders, thereby facilitating the development ...
Di Wang, Xiaobo Zeng, Xinge Wang, Wen Wen, Ping Wang, Shijun Xu   +5 more
wiley   +1 more source

Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina. [PDF]

, 2013
nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes ...
Aller Mañas, Elena, García Tárraga, Patricia, García Verdugo, José Manuel, Gómez Pinedo, Ulises, Jaijo, Teresa, Martínez Fernández de la Cámara, Cristina, Millán Salvador, José María, Rodrigo, Regina, Sequedo, María Dolores   +8 more
core   +2 more sources

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E., Farquharson, Andrew J., Horgan, Graham W, Williams, Lynda M.   +3 more
core   +1 more source

Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

Aging Cell, Volume 23, Issue 11, November 2024.
Aged M‐MDSCs have increased osteoclastogenesis potential. Transcriptomic analyses revealed the upregulation of mitochondrial oxidative phosphorylation and glucose metabolism genes, especially CD38 or NADase. A specific CD38 inhibitor reduced the mitochondrial oxygen consumption rate and glucose metabolism and inhibited the osteoclastogenic potential of
Ramkumar Thiyagarajan, Lixia Zhang, Omar D. Glover, Kyu Hwan Kwack, Sara Ahmed, Emma Murray, Nanda Kumar Yellapu, Jonathan Bard, Kenneth L. Seldeen, Spencer R. Rosario, Bruce R. Troen, Keith L. Kirkwood   +11 more
wiley   +1 more source

Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

Pediatric Obesity, Volume 19, Issue 9, September 2024.
Summary Objective Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association ...
Marcos Olvera‐Rojas, Abel Plaza‐Florido, Patricio Solis‐Urra, Francisco J. Osuna‐Prieto, Francisco B. Ortega   +4 more
wiley   +1 more source