Results 21 to 30 of about 2,983 (148)

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms

Journal of Neuroinflammation, 2011
Background Infection with human immunodeficiency virus type-1 (HIV)-1 leads to some form of HIV-1-associated neurocognitive disorders (HAND) in approximately half of the cases.
Mamik Manmeet K, Banerjee Sugato, Walseth Timothy F, Hirte Renee, Tang Lin, Borgmann Kathleen, Ghorpade Anuja   +6 more
doaj   +1 more source

Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine

American Journal of Physiology-Renal Physiology, 2009
ADP ribosyl (ADPR) cyclases comprise a family of ectoenzymes recently shown to influence cytosolic Ca2+concentration in a variety of cell types. At least two ADPR cyclase family members have been identified in mammals: CD38 and CD157. We recently found reduced renal vascular reactivity to angiotensin II (ANG II), endothelin-1 (ET-1), and norepinephrine
Tiffany L, Thai, William J, Arendshorst
openaire   +3 more sources

Phenotypic Characterization of Acute Systemic and Renal Vascular Responses to Angiotensin II, Norepinephrine, and Endothelin‐1 in Mice Lacking the ADP Ribosyl Cyclase CD38

The FASEB Journal, 2008
Vasoconstriction is mediated by increases in cytosolic calcium concentration ([Ca 2+ ] i ). ADP ribosyl cyclases regulate [Ca2+] i via metabolite activation of Ca 2 ...
Tiffany L Thai, William J Arendshorst
openaire   +1 more source

From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Marco Borso, Jan Ruprecht, Christopher Vorreiter, Sabrina Rast, Lin Zhang, Matthias Schiedel, Wolfgang Sippl, Axel Imhof, Henning J. Jessen, Oliver Einsle, Mike Schutkowski, Manfred Jung   +16 more
wiley   +2 more sources

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source

The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.: CD38-independent ADP-ribosyl cyclase from brain synaptosomes

, 2006
International audiencecADPR (cADP-ribose), a metabolite of NAD+, is known to modulate intracellular calcium levels and to be involved in calcium-dependent processes, including synaptic transmission, plasticity and neuronal excitability.
Moutin, Marie-Jo, Ronjat, Michel, Pochon, Nathalie, Muller-Steffner, Hélène, Baratier, Julie, Villaz, Michel, Ceni, Claire, Schuber, Francis, de Waard, Michel   +8 more
core   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38

, 1996
ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize ...
Prasad, GS, Stura, EA, Stout, CD, Mcree, DE, Levitt, DG, Lee, HC   +5 more
core   +1 more source

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38 [PDF]

, 2014
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation.
Graeff, Richard, Graeff, RM, Hao, Q, Thomas, MP, Swarbrick, Joanna M., Mark P. Thomas (423555), Potter, BVL, Quan Hao (67204), Thomas, Mark P., Zhang, Hongmin, Potter, Barry V L, Hao, Quan, Swarbrick, JM, Hongmin Zhang (1340733), Joanna M. Swarbrick (1285617), Barry V. L. Potter (286876), Zhang, H, Richard Graeff (423553)   +17 more
core   +1 more source