Results 11 to 20 of about 2,983 (148)
Changes in NAD/ADP-ribose metabolism in rectal cancer
Brazilian Journal of Medical and Biological Research, 2005 The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe +5 more
doaj +2 more sources
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins. [PDF]
J Biol ChemInternational audienceBacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems.
Martinkus J +3 more
europepmc +2 more sources
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Frontiers in Genetics, 2022 Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu +10 more
doaj +1 more source
Endogenous ADP-ribosylation of the G Protein β Subunit Prevents the Inhibition of Type 1 Adenylyl Cyclase [PDF]
Journal of Biological Chemistry, 2000 Mono-ADP-ribosylation is a post-translational modification of cellular proteins that has been implicated in the regulation of signal transduction, muscle cell differentiation, protein trafficking, and secretion. In several cell systems we have observed that the major substrate of endogenous mono-ADP-ribosylation is a 36-kDa protein.
Rosita Lupi +2 more
openaire +3 more sources
Scientific Reports, 2021 CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv +9 more
doaj +1 more source
Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. [PDF]
PLoS ONE, 2013 Preceding studies on the mode of action of non-genotoxic hepatocarcinogens (NGCs) have concentrated on alterations induced in hepatocytes (HCs). A potential role of non-parenchymal liver cells (NPCs) in NGC-driven hepatocarcinogenesis has been largely ...
Philip Klepeisz +5 more
doaj +1 more source
Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157) [PDF]
Biochemical Journal, 1999 cADP-ribose, which is produced by ecto-ADP-ribosyl cyclase of CD38 or bone marrow stromal cell antigen-1 (BST-1), is a key regulator of Ca2+-induced calcium release in an Ins(1,4,5)P3-independent manner. In the present study, we have identified a specific peptide inhibitor for ADP-ribosyl cyclase of BST-1.
A, Sato +4 more
openaire +2 more sources
Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]
, 1992 3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland +3 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2014 CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in
Olga eLopatina +29 more
doaj +1 more source