Results 41 to 50 of about 138,386 (251)
A functional gammadeltaTCR/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils. [PDF]
PLoS ONE, 2009 BACKGROUND:Eosinophils are effector cells during parasitic infections and allergic responses. However, their contribution to innate immunity has been only recently unravelled. METHODOLOGY/PRINCIPAL FINDINGS:Here we show that human eosinophils express CD3
Fanny Legrand +11 more
doaj +1 more source
Frontiers in Immunology, 2022 Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex.
Casimiro Luca Gigliotti +27 more
doaj +1 more source
CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer
Frontiers in Oncology, 2022 The protein encoded by CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction.
Li Yuan +16 more
doaj +1 more source
The transmembrane orientation of the ϵ chain of the TcR/CD3 complex
European Journal of Immunology, 1988 AbstractThe antigen receptor of the T lymphocytes is one of the most complex eukaryotic membrane structures studied to date. The T cell receptor (TcR) consists of two disulfide‐linked glycoprotein chains (α/βor γ/δ) and is noncovalently associated with a group of small and invariable CD 3 proteins.
Clevers, J.C., Dunlap, S., Terhorst, C.
openaire +3 more sources
Pathogens, 2020 The unusual phenotype of CD3+ T lymphocyte expressing B220, a marker originally attributed to B lymphocytes, was first observed in the liver of Fas/Fas-L-deficient mice as a marker of apoptotic T lymphocytes.
Natalia Vacani-Martins +9 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Microbiology Spectrum, 2022 HIV-1 sequence population structure among brain and nonbrain cellular compartments is incompletely understood. Here, we compared proviral pol and env high-quality consensus single-molecule real-time (SMRT) sequences derived from CD3+ T cells and CD14 ...
Rebecca Rose +8 more
doaj +1 more source
Biomolecules & BiomedicineKirsten Rat Sarcoma viral oncogene homolog (KRAS) is one of the most frequent oncogenes. However, there are limited treatment options due to its intracellular expression.
Changchang Lu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source