Results 21 to 30 of about 138,386 (251)
Immunological cluster complexes in kidney transplantation
Медицинская иммунология, 2022 Laboratory tests are significant for the detection of immunopathological disorders in kidney transplantation. As a rule, the choice of tests is carried out individually and is based on the clinical characteristics and the presumptive diagnosis.
S. V. Zybleva, S. L. Zyblev
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Structures of human γδ T cell receptor-CD3 complex. [PDF]
NatureAbstractGamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology1–3. The γδ T cell receptor (TCR), which is generated by γδ T cells, recognizes a diverse range of antigens independently of the major histocompatibility complex2.
Xin W +8 more
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Pharmaceutics, 2022 The T cell-dependent bispecific (TDB) antibody, anti-CD79b/CD3, targets CD79b and CD3 cell-surface receptors expressed on B cells and T cells, respectively.
Rajbharan Yadav +18 more
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Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity
mAbs, 2023 Bispecific antibodies continue to represent a growth area for antibody therapeutics, with roughly a third of molecules in clinical development being T-cell engagers that use an anti-CD3 binding arm.
Catherine Y Liu +8 more
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Deconstructing the Form and Function of the TCR/CD3 Complex [PDF]
Immunity, 2006 When T cells encounter antigens via the T cell antigen receptor (TCR), information about the quantity and quality of antigen engagement is relayed to the intracellular signal transduction machinery. This process is poorly understood. The TCR itself lacks a significant intracellular domain.
Kuhns, Michael S. +2 more
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Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors
Molecular Therapy: Methods & Clinical Development, 2023 CD3-targeted lentiviral vectors (CD3-LVs) mediate selective transduction of human T lymphocytes in vitro and in vivo while simultaneously activating the targeted cells.
Angela H. Braun +3 more
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Murine RAW Macrophages Are a Suitable Model to Study the CD3 Signaling in Myeloid Cells
Cells, 2022 In recent years, a growing body of evidence has shown the presence of a subpopulation of macrophages that express CD3, especially in the context of mycobacterial infections.
Ranferi Ocaña-Guzmán +5 more
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The TCR/CD3 Complex: Opening the Gate to Successful Vaccination [PDF]
Current Pharmaceutical Design, 2009 The success of vaccination is directly or indirectly based on the specificity of antigen recognition by T lymphocytes, their efficient activation and expansion, and the generation of vaccine-specific effectors and memory cells. These traits are largely dependent on the correct assembly and expression of sufficient number of functional TCR/CD3 complexes
Portolés, Pilar, Rojo, José María
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Proteomic and Metabolomic Profiles of T Cell-Derived Exosomes Isolated from Human Plasma
Cells, 2022 Exosomes that are released by T cells are key messengers involved in immune regulation. However, the molecular profiling of these vesicles, which is necessary for understanding their functions, requires their isolation from a very heterogeneous mixture ...
Aneta Zebrowska +7 more
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مجله دانشکده پزشکی اصفهان, 2018 Background: Some of studies showed intraepithelial lymphocyte and CD3 marker can be used in diagnosis of celiac disease with a high sensitivity and specificity, but there is controversy in these studies.
Mojgan Mokhtari +2 more
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